About: Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design

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About: Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design Goto Sponge NotDistinct Permalink

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rdf:type	Item
description	wetenschappelijk artikel (nl) bài báo khoa học (vi) scientific article (preprint) (en) artículu científicu espublizáu'l 9 de marzu de 2020 (ast)
publication date	wds:Q88976382-319D8F64-7CCD-4A3C-A60D-6D74E6A23DA7
publication date	2020-03-09 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q88976382-BF45D72E-1A43-4928-8A3F-F3330BE8725C
language of work or name	English
cites work	wds:Q88976382-27F4985B-DC31-45D8-8B9F-ADA8F5441003 wds:Q88976382-35BDAAB5-EB92-4E54-B086-4F2D3A943CB4 wds:Q88976382-4B21C997-C792-4F2E-98A3-9F10D194177A wds:Q88976382-4C122435-AA71-4526-AD28-06E839F4D532 wds:Q88976382-4F1555D4-EF22-4EF4-9DB5-34B2E440BBCF wds:Q88976382-6A2EAA3E-F4C6-47ED-8CCD-21B443692CE3 wds:Q88976382-6F74DEBB-783F-411A-9702-A52F9C92A032 wds:Q88976382-7A709EAB-5677-47DD-BECD-AB5C33F07B77 wds:Q88976382-7CFFBB8A-FC71-43A2-8D1B-E339D045A502 wds:Q88976382-83BC4AFB-B8ED-4B42-B625-8F2EFC13CB4E wds:Q88976382-8E0C7681-DFFB-4053-92B8-613095A289AA wds:Q88976382-9CCE9575-63A8-467E-BE7E-DCD9BBFFBC88 wds:Q88976382-A27EF3F3-7DFB-4E9F-B094-AF073A760ECF wds:Q88976382-A5107657-7D13-45BC-965F-5F044B2730FB wds:Q88976382-B41F6721-7576-4D9D-B563-4EBDA20536A6 wds:Q88976382-C777FD44-00FE-4B71-BF33-BEAD4C0FD923 wds:Q88976382-CD8E462A-9B85-4325-BFF0-4B5B24726ADA wds:Q88976382-D19134A7-5FC2-4277-BCC1-3AC6E17337DE wds:Q88976382-DF3DAA04-8BD8-4DE6-8CE4-521264926912 wds:Q88976382-E01D9954-10C5-4929-B911-68187FC951DF wds:Q88976382-E30FDEB0-BEE6-4D82-826D-0779D090B975 wds:Q88976382-E9E5D3C2-798D-4301-B3B2-2724ACC48096 wds:Q88976382-EE5900E1-4A49-41A4-BEE4-05D2E3171DB8 wds:Q88976382-FB81229E-9828-4029-87EB-23BD17F45501
cites work	Overview of the CCP4 suite and current developments Features and development of Coot From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design Profiling of substrate specificities of 3C-like proteases from group 1, 2a, 2b, and 3 coronaviruses REFMAC5 for the refinement of macromolecular crystal structures Scaling and assessment of data quality The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor Molecular replacement with MOLREP An introduction to data reduction: space-group determination, scaling and intensity statistics XDSAPP: a graphical user interface for the convenient processing of diffraction data usingXDS Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs JLigand: a graphical tool for the CCP4 template-restraint library Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore. Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy. Small Molecule Active Site Directed Tools for Studying Human Caspases Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China A distinct name is needed for the new coronavirus Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes. Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples Applications of Unnatural Amino Acids in Protease Probes
author name string	wds:Q88976382-241D4DE8-E647-4970-B15E-53E52E7829CC wds:Q88976382-57E12460-F9E3-470C-8D55-F4482F1EFA55 wds:Q88976382-9FDD7541-97DB-4F74-A6AA-684B8E1AAD6C wds:Q88976382-BFEABE2C-3920-4FBE-84D3-26143FB2715C wds:Q88976382-F5D6591B-7708-4969-AEDD-32517BF24618
author name string	Linlin Zhang Katarzyna Groborz Xinyuanyuan Sun Wioletta Rut Mikolaj Zmudzinski
rdfs:label	Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design (en) Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design (nl) Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design (ast)
skos:prefLabel	Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design (en) Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design (nl) Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design (ast)
name	Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design (en) Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design (nl) Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design (ast)
author	wds:Q88976382-9BFEB9C9-D8B3-4A42-AA6A-0A70B90E63B1 wds:Q88976382-F3396032-5494-4B2C-A403-27B3DE69E6E3
author	Marcin Drąg Rolf Hilgenfeld
title	wds:Q88976382-C2324925-F0D6-433E-841C-8B1257E6491F
title	Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design (en)
followed by	wds:Q88976382-06500253-4f52-4f8f-f304-3569449f64b0
instance of	wds:Q88976382-80734B69-B1AC-4DFC-B256-9C0257C6C34F
followed by	Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design
instance of	preprint
main subject	wds:Q88976382-34110a39-4d65-4302-b766-ec04903944a4 wds:Q88976382-356FA824-E46D-4DCE-AB98-23389D3D6605 wds:Q88976382-5B5DC340-9FD2-43C6-BAA0-0EB852E5DF85 wds:Q88976382-E488DA7D-A246-44D7-9CD0-0C8E8E56A94D wds:Q88976382-d373c321-47f0-dab5-8cf6-310f88c7f719
main subject	SARS-CoV-2 COVID-19 pandemic COVID-19 mortality S-Acetonylcysteine non-structural protein 5 [SARS-CoV-2]
published in	wds:Q88976382-A4F84523-827F-4B36-A52C-EE2E7EA43CE8
published in	bioRxiv
DOI	wds:Q88976382-DCAEB2F1-5FD6-4882-9487-9D0BC807FFED
DOI	http://dx.doi.org/10.1101/2020.03.07.981928

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