About: non-structural protein 5 [SARS-CoV-2]

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About: non-structural protein 5 [SARS-CoV-2] Goto Sponge NotDistinct Permalink

An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

protein of SARS-CoV-2

Attributes	Values
rdf:type	Item
description	بروتين (ar) protein of SARS-CoV-2 (en) proteïne in SARS-CoV-2 (nl)
rdfs:label	nestrukturni protein 5 [SARS-CoV-2] (sl) non-structural protein 5 [SARS-CoV-2] (en) non-structural protein 5 [SARS-CoV-2] (nl)
skos:prefLabel	nestrukturni protein 5 [SARS-CoV-2] (sl) non-structural protein 5 [SARS-CoV-2] (en) non-structural protein 5 [SARS-CoV-2] (nl)
name	nestrukturni protein 5 [SARS-CoV-2] (sl) non-structural protein 5 [SARS-CoV-2] (en) non-structural protein 5 [SARS-CoV-2] (nl)
physically interacts with	wds:Q87917582-68FD314B-0FAB-4B54-956C-E225AF5D9C11 wds:Q87917582-86A4B688-E6C2-4747-980E-0385C5F41434 wds:Q87917582-a1d4abb6-4a13-e165-6997-bb532824130e wds:Q87917582-d33fdb1e-4dc5-5e8b-175b-8ef8d1657516
physically interacts with	wd:Q21157938 wd:Q5773155 TRNA methyltransferase 1 TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae), isoform CRA_c
instance of	wds:Q87917582-B17EE589-B983-4523-92A6-0DF0F38DCB3D wds:Q87917582-B7995D4F-26F3-436A-AE59-3E6A3B12A5F2
instance of	protein protein fragment
subclass of	wds:Q87917582-14f82805-4d99-7798-9304-e9126b5d0961 wds:Q87917582-9CADFD4A-5CF7-40C9-A4B6-2A3CD9FF55D5
subclass of	SARS coronavirus main proteinase protein fragment
found in taxon	wds:Q87917582-D6048FF2-1590-460B-90F7-D61AC45D280F
found in taxon	SARS-CoV-2
short name	wds:Q87917582-b68219da-4e93-c7bc-bf63-11e3b2e7e4d1
short name	nsp5 (en)
PDB structure ID	wds:Q87917582-39449A38-1932-41CB-921E-8CB58FD53A80 wds:Q87917582-5B59E8E8-D44D-422E-9320-F2DECC604FF3 wds:Q87917582-700b4483-452e-e93c-db1c-f4420b6a9b5a wds:Q87917582-7D0088CE-EDB3-44CE-B57D-E42783A8F2F6 wds:Q87917582-B087B430-D0FF-4550-99BD-208C03474F8B wds:Q87917582-B2F0083D-23A3-422C-AE52-30A4B8D67C13 wds:Q87917582-BE282C5A-CB1C-40CC-8288-A3C1A5EFEBCB wds:Q87917582-ECCCAAEF-E490-4371-9179-53C189995499
PDB structure ID	https://rdf.wwpdb.org/pdb/6Y84 https://rdf.wwpdb.org/pdb/5R81 https://rdf.wwpdb.org/pdb/5R82 https://rdf.wwpdb.org/pdb/5R83 https://rdf.wwpdb.org/pdb/6LU7 https://rdf.wwpdb.org/pdb/6M03 https://rdf.wwpdb.org/pdb/6Y2E https://rdf.wwpdb.org/pdb/6Y2F
PDB structure ID	6Y84 5R81 5R82 5R83 6LU7 6M03 6Y2E 6Y2F
skos:altLabel	3CLp (en) Mpro (en) 3C-like proteinase (en) 3CLPRO (en) Nsp5 (en) SARS-CoV-2 main protease (en) nsp5 (en)
UniProt protein ID	wds:Q87917582-26CB64C1-8B3C-45D9-AF8E-3D8F099ABAA3 wds:Q87917582-3D81F126-A8DD-43FE-BBD5-BE55D814A993
RefSeq protein ID	wds:Q87917582-de859bce-46ba-e69d-2eba-6b3e60f5dae3
UniProt protein ID	uniprot:uniprot/P0DTC1-PRO_0000449639 uniprot:uniprot/P0DTD1-PRO_0000449623
RefSeq protein ID	uniprot:refseq/YP_009725301
UniProt protein ID	P0DTC1-PRO_0000449639 P0DTD1-PRO_0000449623
RefSeq protein ID	YP_009725301
Guide to Pharmacology Target ID	wds:Q87917582-9A3DF8FA-9F06-4243-A168-C9FC41B4143B
Guide to Pharmacology Target ID	3111
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q87917582
is instance of of	Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection
is instance of of	wds:Q107011866-411b79a6-47f8-553f-ca46-2e2afedd2ec6
is has part(s) of	SARS-CoV-2 main protease complex Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway SARS-CoV-2 and COVID-19 pathway
is main subject of	Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors A SARS-CoV-2 protein interaction map reveals targets for drug repurposing Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design Structure of Mpro from COVID-19 virus and discovery of its inhibitors Structure of Mpro from COVID-19 virus and discovery of its inhibitors Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins SARS-CoV-2 3C-like protease antagonizes interferon-beta production by facilitating the degradation of IRF3 Crystal structure of the free enzyme of the SARS-CoV-2 (2019-nCoV) main protease The crystal structure of COVID-19 main protease in apo form COVID-19 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, SARS-CoV-2) Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

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