About: p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

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About: p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice Goto Sponge NotDistinct Permalink

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article published in 2009

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) article scientifique publié en 2009 (fr) наукова стаття, опублікована в серпні 2009 (uk) im August 2009 veröffentlichter wissenschaftlicher Artikel (de) article published in 2009 (en)
publication date	wds:Q57631318-D70A3B15-1FA4-45E1-AF80-467791276CB3
publication date	2009-08-30 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q57631318-7BD1BB48-218B-4C31-A889-95A1E3D4CABA
language of work or name	English
exact match	wds:Q57631318-9C4C82F8-F151-405E-A4B4-62F50124E39E
exact match	https://scigraph.springernature.com/pub.10.1038/ng.426
cites work	wds:Q57631318-01118B4B-C1B7-4113-BC56-2A7CDDBE175C wds:Q57631318-07B95183-A9DB-41F2-B8E5-00080EB44D57 wds:Q57631318-15441C0C-7FA2-4855-AB63-A64D35552169 wds:Q57631318-1F143829-6419-4F6B-BDBE-F71721E3619D wds:Q57631318-22C02148-30A8-451A-BB3B-FF084ABA3616 wds:Q57631318-29E03D2F-6BFD-4355-986F-3A077B5A7952 wds:Q57631318-2CCCE45A-8DB9-4B86-B71E-A7215B2F168B wds:Q57631318-349366A5-1338-45AF-8441-0C361F525B0B wds:Q57631318-39C57599-4111-4A0A-9C0A-9ABA25F070BF wds:Q57631318-43FFBFDD-60DD-48F0-AA9C-6730D5737EA5 wds:Q57631318-5433BD41-F5C5-440F-B85B-F166C4FB90C4 wds:Q57631318-5FF150C7-90EF-4467-908C-2887E0936BD9 wds:Q57631318-66C51ADD-C028-42CE-8505-62B00843FB5E wds:Q57631318-774DC132-B077-4D40-A4BD-0BC94295DB22 wds:Q57631318-7F3CC678-96C1-40B7-A6FE-3F05F75F6FF8 wds:Q57631318-81611458-FFDF-4F33-BAF1-44FD7D2FBBD5 wds:Q57631318-8FEFC40E-E4BE-4B21-8E40-1FC01F2DB8AF wds:Q57631318-901D4FCD-444F-4CFA-BAAB-F58D6AD6BA72 wds:Q57631318-9E4775A0-B930-4216-BEFB-BA58728B2618 wds:Q57631318-AA88E36C-E3B1-4FE6-9061-1896A2FC4EA9 wds:Q57631318-C1560FCE-4CEF-43DF-8CFF-7D5496A9B332 wds:Q57631318-C308A9AD-0576-43F2-A91C-18E0C8A4ABC7 wds:Q57631318-CBF6D41E-6C7F-4687-BFF2-D13E76242B04 wds:Q57631318-D28B82FA-4DBE-470A-A1A6-9B50DB629EE1 wds:Q57631318-D7D4676A-5997-48B7-8B66-834ACE5D6B31 wds:Q57631318-D8CFE1C9-ECF7-4F5B-9781-DA2BA0955A75 wds:Q57631318-DC524CAF-487D-4A81-874C-041BBF2D8AA3 wds:Q57631318-E88B0FE9-4C1B-42A9-B4E3-5333B016BDC3 wds:Q57631318-EEC69E5F-98CE-4780-9015-CBAA6123B5C5 wds:Q57631318-F79BB154-40D9-4361-9387-D09A27B670A7 wds:Q57631318-FE74DB3F-2AD3-46F6-BF9A-7D95EF1E25F4
cites work	Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice Telomere dysfunction and evolution of intestinal carcinoma in mice and humans "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability Telomerase reverse transcriptase delays aging in cancer-resistant mice Increased p53 activity does not accelerate telomere-driven ageing Delayed ageing through damage protection by the Arf/p53 pathway Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice Telomere length measurements using digital fluorescence microscopy How stem cells age and why this makes us grow old. Stem cells, ageing and the quest for immortality. A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization Tissue-specific and inducible Cre-mediated recombination in the gut epithelium Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation The two-stage mechanism controlling cellular senescence and immortalization A multiplex PCR predictor for aCGH success of FFPE samples p53 mutant mice that display early ageing-associated phenotypes Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Identification of stem cells in small intestine and colon by marker gene Lgr5 Transcription factor achaete scute-like 2 controls intestinal stem cell fate Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease Single-cell isolation from cell suspensions and whole genome amplification from single cells to provide templates for CGH analysis Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres Telomeric fusions in cultured human fibroblasts as a source of genomic instability Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use? Ageing, repetitive genomes and DNA damage
author name string	wds:Q57631318-06C5D6AA-C734-4610-8D40-A73C1B7B1B4B wds:Q57631318-1C2D09B0-290D-47E3-AAE6-6A00236275C3 wds:Q57631318-2E3A0DA2-4ECB-4410-B067-5FE07DE2471F wds:Q57631318-33C3A402-60C0-4B85-8D2D-6D8B4BC5D200 wds:Q57631318-3D9C89F8-B26A-4A60-8DBC-C261A539B4EF wds:Q57631318-7D3E6DEC-6358-438F-87C5-85E5B9FF5331 wds:Q57631318-9861DF44-4D2C-4B01-B4FE-F765818B34D3 wds:Q57631318-C5CAC1F5-A651-453F-B13B-B143A154A208
author name string	Nick Barker Falk Schlaudraff André Lechel Peter Schirmacher K Lenhard Rudolph Eva Hoffmann Esther Danenberg Elvira Peit
rdfs:label	p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice (en) p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice (nl)
skos:prefLabel	p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice (en) p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice (nl)
name	p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice (en) p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice (nl)
author	wds:Q57631318-2B6423D8-8F7A-4188-B643-3F38C5ABD0A1 wds:Q57631318-32DC90F2-F88F-4BE7-BB42-4E9F67F8D895 wds:Q57631318-4F0DC26E-1B8E-421D-8A6D-D9CD62CA8A94 wds:Q57631318-50C7C7D7-4A5E-4C53-9C51-7024B31088CC

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