About: Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

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About: Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation Goto Sponge NotDistinct Permalink

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scientific article published on 03 December 2006

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в грудні 2006 (uk) im Dezember 2006 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'avientu de 2006 (ast) scientific article published on 03 December 2006 (en)
publication date	wds:Q60284598-3830054F-AD44-480C-B6F6-091DB3FC377F
publication date	2006-12-03 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q60284598-F33330B1-9AC3-4A0D-B653-904EEEDAF69C
language of work or name	English
exact match	wds:Q60284598-A9DF5D96-A25B-404A-9EA1-27C6F9250852
exact match	https://scigraph.springernature.com/pub.10.1038/ng1937
cites work	wds:Q60284598-0099F370-BE95-4C8C-8E9D-B7B4D09C9A32 wds:Q60284598-0ECEAFE0-0269-4AB1-B03D-2A37893C9B1E wds:Q60284598-13CBF632-F575-4FED-B8F2-4A9C72B92F33 wds:Q60284598-19E285F6-B7D9-4B6B-94B9-B6104678E347 wds:Q60284598-299946C4-7F21-43CE-978F-14EF3E149998 wds:Q60284598-2F774F33-1756-4F1E-9FB1-B1AA6F888AC4 wds:Q60284598-309E730A-5159-483D-BD9F-28A696A1DAFB wds:Q60284598-335766C0-F8A7-4B10-8242-FFB5E68A5CAB wds:Q60284598-4A90FD43-8412-4D3B-996C-A451635EF6DF wds:Q60284598-4CE3950A-2D27-4876-B2FF-BA6C0F388D14 wds:Q60284598-4FD2C0DE-19DB-4B9B-930F-F233C98F2292 wds:Q60284598-508087DC-92F7-435B-A6CC-FC15FA01762F wds:Q60284598-5DD5655D-7AB9-4CFF-92BD-837C2B921886 wds:Q60284598-7165C803-C6DA-41C8-A8D3-8D139F66498B wds:Q60284598-791E47CA-A30D-4B31-9C18-8417B8908888 wds:Q60284598-7FFDEB4C-B26E-4B8D-8FCD-FE574EEFB563 wds:Q60284598-8C8A1770-02D9-48B3-A806-508B81DF682B wds:Q60284598-8ED6A092-122D-479F-BE5E-47D26321118B wds:Q60284598-9F6078AC-86A7-405E-A560-7044B31F98DF wds:Q60284598-A5B32E20-BB17-4E41-B52E-3651EBD600E6 wds:Q60284598-B2FD4F7B-3F69-4834-88D9-AC587270204B wds:Q60284598-B5DC292A-C4EF-4CEE-A6AE-53872703719C wds:Q60284598-BDECD4EB-C8D0-46E6-B418-8E6F69C8EE9E wds:Q60284598-C135C5C2-EB9B-4DBB-A9F3-BAB6C8D04F87 wds:Q60284598-C2D0F56A-8ADD-4017-B8F4-AA57EB89420D wds:Q60284598-CECB1C09-FF14-420C-8F95-DBAF003BFDD6 wds:Q60284598-E954E31D-8809-4FC7-9E96-879D8EA124F3 wds:Q60284598-FC7BB6EC-C2C6-46BC-A400-F28CE543F090 wds:Q60284598-FE5986D9-72AD-4138-A812-63FA9A722AC0
cites work	Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a) Absence of p21WAF1 cooperates with c-myc in bypassing Ras-induced senescence and enhances oncogenic cooperation. The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo. Essential role of mouse telomerase in highly proliferative organs Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice Telomere dysfunction and evolution of intestinal carcinoma in mice and humans Developmental and tissue-specific regulation of mouse telomerase and telomere length Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC. The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis Telomere shortening and tumor formation by mouse cells lacking telomerase RNA Short telomeres, even in the presence of telomerase, limit tissue renewal capacity Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice Hematopoietic stem cell quiescence maintained by p21cip1/waf1 Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse The two-stage mechanism controlling cellular senescence and immortalization Disease states associated with telomerase deficiency appear earlier in mice with short telomeres DNA repair, genome stability, and aging Telomere length predicts replicative capacity of human fibroblasts A DNA damage checkpoint response in telomere-initiated senescence Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis Age-associated characteristics of murine hematopoietic stem cells Characterization of a population of cells in the bone marrow that phenotypically mimics hematopoietic stem cells: resting stem cells or mystery population? Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells Effects of aging on early B- and T-cell development. Ageing, repetitive genomes and DNA damage
author name string	wds:Q60284598-2FF01F3B-FE04-419E-8CBD-1D7501612925 wds:Q60284598-3D1CE6D1-4208-4EE6-8F4F-6FB3317F8642 wds:Q60284598-3E14E730-2D4E-4CB2-8CFC-684D9E2A811F wds:Q60284598-71C2B2CF-D183-4DE4-9190-BFDC62112AF7 wds:Q60284598-73094FC3-A8C0-4938-A900-DE1B28859AB8 wds:Q60284598-7A8C31E8-A0D8-40BC-8581-D370F0BB55A3 wds:Q60284598-7ABF4E9F-0577-4905-B64B-E5C239EE60FA wds:Q60284598-84F1B750-3629-49EA-8750-0A4A7C19ECBC wds:Q60284598-A43D637E-9E4E-481B-960F-C85D93A236AC wds:Q60284598-B7A87099-4EC7-4E77-89CE-B906D487054D wds:Q60284598-C3C28C5B-4963-493B-B6E8-B1D68ABCB13D wds:Q60284598-D22012EC-E37E-481A-997D-BC201A48A6D9 wds:Q60284598-D44C2C91-C2CC-4DA8-81FE-DC8191456DBB wds:Q60284598-E01706EB-72AB-4E05-A93F-9EB2EE3009B4
author name string	Hong Jiang Arnold Ganser Chunfang Wang Hiromitsu Nakauchi Zhenyu Ju Peter Schirmacher Jan Buer Han-Woong Lee Aaheli Roy Choudhury Anna Stepczynska Sonja Schaetzlein Meta W Djojosubroto Andrea Schienke Andre Lechel
rdfs:label	Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation (en) Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation (nl)

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