About: Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

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description	artículu científicu espublizáu en 2011 (ast) наукова стаття, опублікована в жовтні 2011 (uk) vědecký článek publikovaný v roce 2011 (cs) 2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած (hyw) 2011 թվականի հոտեմբերին հրատարակված գիտական հոդված (hy) vedecký článok (publikovaný 2011/10/27) (sk) مقالة علمية (نشرت في 27-10-2011) (ar) article scientifique publié en 2011 (fr) wetenschappelijk artikel (gepubliceerd op 2011/10/27) (nl) scientific journal article (en) im Oktober 2011 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q28591763-75C1E297-0F33-4C3F-AAC6-9DEFAD378F66
publication date	2011-10-27 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28591763-17CD578C-DCDB-4454-B5CF-E3949BD473FC
language of work or name	English
cites work	wds:Q28591763-0A21C5E7-821F-46AF-B764-292549214DE7 wds:Q28591763-0FBF094D-F5F8-4679-8DD8-ECC8C0504060 wds:Q28591763-2C5FA0F1-0F76-46A3-9CEA-869B46B8819E wds:Q28591763-30FB0224-ABF3-4C91-85B6-FF319D443A2B wds:Q28591763-32D38FDA-51B1-4895-BAED-69A0CB9EF2CC wds:Q28591763-3823BACD-227C-4004-9B66-DBB0D1FD95ED wds:Q28591763-38533EF2-B578-40C3-9068-840AA0A84002 wds:Q28591763-399B86F9-9F9C-42DE-B17F-0345719AF42E wds:Q28591763-3D002148-7FD4-40E0-AF17-840C79AAB128 wds:Q28591763-4385956B-2C76-4B16-914F-074995AB92AB wds:Q28591763-4C092257-7714-456A-AED4-4DD15D86E2B1 wds:Q28591763-4DEC36A6-DEA8-4A97-B869-57F1E41A3546 wds:Q28591763-5776E2AC-2443-4C15-BA63-63AB8E50730B wds:Q28591763-579B9C7C-C727-4E12-8ACF-B95E883CF51F wds:Q28591763-5BC2B1C9-3E28-4564-98E5-506841B3F583 wds:Q28591763-5DAF5981-E692-410A-8D93-503E5676249D wds:Q28591763-76DCD71C-E920-4813-9C90-BA037AE9A43C wds:Q28591763-78E5D388-D1A1-483A-B8FC-B4F8D9ADEC4C wds:Q28591763-7C7314E8-48CB-416B-8B19-FE0C8C578BB4 wds:Q28591763-88FBEB1E-97FE-4024-A900-8CAB21396173 wds:Q28591763-9F61C65E-27BE-46A9-A768-E422E1565B8D wds:Q28591763-B124ACB6-46B4-4587-AC5A-087570FB581C wds:Q28591763-B1B9903F-E7CF-4F8D-A6F5-BE3E4AA39F23 wds:Q28591763-C35DA820-A097-4A1C-8D1E-46C8A4E1FBDA wds:Q28591763-CB3F59F9-142C-4AE4-8FAB-3173FB45C977 wds:Q28591763-D3011CE9-0CFC-48D7-9A69-15793B1FBAB3 wds:Q28591763-E10730B2-510B-48F4-8920-FBFC32688112 wds:Q28591763-E3D9B364-D636-4CFF-9A7E-2FD65BAF612D wds:Q28591763-F31BAC07-D9B2-455B-B649-C4BF4333760F
cites work	Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2 Mutation in TET2 in myeloid cancers TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis A myocardial lineage derives from Tbx18 epicardial cells TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1 Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine. LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). Acquired mutations in TET2 are common in myelodysplastic syndromes Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML. Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. AML1 deletion in adult mice causes splenomegaly and lymphomas. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms Stimulation of mouse and human primitive hematopoiesis by murine embryonic aorta-gonad-mesonephros-derived stromal cell lines.
author name string	wds:Q28591763-15E2EE5A-9D02-48E4-8180-B3729D613980 wds:Q28591763-1B50440A-7F1C-4E58-BB13-DDAB865D5580 wds:Q28591763-4537E43E-9BE0-4E01-A72D-536FE97BBB15 wds:Q28591763-53C393AB-DEED-4AE4-999C-5660AE2714B4 wds:Q28591763-6EE3E82D-2C0F-4B3C-BD23-41F040BF8863 wds:Q28591763-8A493D48-8FDC-4BE8-8EF8-9F4FC23693DB wds:Q28591763-961F727C-15AA-4D56-A761-12DBBAD5835E wds:Q28591763-EA0DC0CD-3841-414A-A049-1FAB2CE4D863
OpenCitations bibliographic resource ID	wds:Q28591763-FE6AC873-74DA-4DEF-A957-B0545E73784C
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/644719
author name string	Zhe Li Feng-Chun Yang Mingjiang Xu Jiapeng Wang Chen-Leng Cai Wenyong Zhang Xiaoqiang Cai Bruce E. Petersen
OpenCitations bibliographic resource ID	644719
rdfs:label	Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies (en) Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies (nl) Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies (ast)
skos:prefLabel	Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies (en) Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies (nl) Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies (ast)
name	Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies (en)

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