About: Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

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About: Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression Goto Sponge NotDistinct Permalink

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description	artículu científicu espublizáu en 2007 (ast) vědecký článek publikovaný v roce 2007 (cs) 2007 թուականի Յունիսին հրատարակուած գիտական յօդուած (hyw) 2007 թվականի հունիսին հրատարակված գիտական հոդված (hy) наукова стаття, опублікована в червні 2007 (uk) 2007年學術文章 (zh) vedecký článok (publikovaný 2007/06/19) (sk) مقالة علمية (نشرت في 19-6-2007) (ar) wetenschappelijk artikel (gepubliceerd op 2007/06/19) (nl) article publié dans les Proceedings of the National Academy of Sciences of the United States of America (fr) scientific journal article (en) im Juni 2007 veröffentlichter wissenschaftlicher Artikel (de) 2007 ജൂണ്‍ 19 നു പ്രസിദ്ധീകരിച്ച ശാസ്ത്ര ലേഖനം (ml)
publication date	wds:Q28585864-79598025-53CD-4C37-88F3-8A6A7B0C869D
publication date	2007-06-19 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28585864-BF7792D1-F398-40A6-BC51-A149A0DF809D
language of work or name	English
cites work	wds:Q28585864-043E56AB-0DCD-40F2-B350-607D0F268B33 wds:Q28585864-0BB2ACE4-0256-420D-A0AA-D3E6730CD3EF wds:Q28585864-0D8F5453-A2EA-4D03-B5B1-9A618F7EFA4E wds:Q28585864-10F26412-0DFD-4C10-BC71-EE8FCC038163 wds:Q28585864-14DC6CDD-A0D8-4C4A-8FDA-DABBD53ED708 wds:Q28585864-24B1E723-AEEA-4708-A886-73492E0EB763 wds:Q28585864-2A96A1E4-11DB-46C8-82CD-6EB27525E4D0 wds:Q28585864-38BA0ACB-A030-4D27-B28A-A5E7C710FD54 wds:Q28585864-3F7C3020-1668-43AF-851C-AA15E561C318 wds:Q28585864-4070EF65-8392-4D9F-AC49-7AB6372BBF49 wds:Q28585864-44B47393-E554-402E-96D6-00921C65A473 wds:Q28585864-46C861DF-172A-4DEC-81ED-A4A7E93458AC wds:Q28585864-48D1B15F-4ABC-4C2D-906D-75EDF9B8690D wds:Q28585864-4FCFEF1B-084E-4219-B8F3-4AA7C84399D7 wds:Q28585864-5E37B70E-34C7-4AC8-8D90-4E004E870FF3 wds:Q28585864-6A422650-BE5B-45DF-B0B1-1CB938B5B797 wds:Q28585864-77FBC4EB-978A-41EE-AC05-C5907DF96652 wds:Q28585864-7E7096F8-625E-4D81-89DF-C84B0D07B797 wds:Q28585864-85132B5E-7A09-4376-AD5B-7C4C01BE802A wds:Q28585864-8EA36AB1-F869-4F77-84B6-2BF7E8B674B8 wds:Q28585864-99F721FB-1B7D-4239-AA96-D7281D5DBB0F wds:Q28585864-9C153F9F-3A51-4764-89C2-CA245D4F7709 wds:Q28585864-9D21E26A-FF82-4743-928C-442541358988 wds:Q28585864-A0AD3DA5-1B37-48DB-B2B4-E91E1C1231F5 wds:Q28585864-A3C37D49-9C9C-47C1-94AA-CB2039C28CA9 wds:Q28585864-AFF4558F-2217-45F2-B57E-173814BFB684 wds:Q28585864-B07B673F-9FD0-4E1D-B6B3-8ECB702AC1F2 wds:Q28585864-B9193D98-BB3D-4D57-980B-20677F32EA0A wds:Q28585864-C71ABFAA-830D-4068-865D-22CAE4BA3619 wds:Q28585864-CBDEF2E6-DE33-4912-AFE5-28E45BAD5880 wds:Q28585864-CDCD3050-B71F-4B7F-964A-A3DDDC4894EB wds:Q28585864-D4D170C3-C1DD-44EE-AC79-FF02AF45169C wds:Q28585864-D5DDBD6E-7B4D-4BD8-BCEC-658D98F0B441 wds:Q28585864-D690375C-131F-4F62-AFA6-236CD182EB77 wds:Q28585864-EE1B45ED-9089-490B-905F-C5B67B3CF3FB wds:Q28585864-EF269B1E-6A45-4EC6-BEC6-E8A57A0DB23A wds:Q28585864-F00250F4-7A1D-4067-951D-E0B02CE11282
cites work	Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo Pathological and physiological functions of presenilins Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2 Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain Skeletal and CNS defects in Presenilin-1-deficient mice Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor The amyloid precursor protein: beyond amyloid The gamma-secretase complex: machinery for intramembrane proteolysis Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis A common enzyme connects notch signaling and Alzheimer's disease Mice lacking both presenilin genes exhibit early embryonic patterning defects Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage EGF-ERBB signalling: towards the systems level A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60 Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET. Notch1 is essential for postimplantation development in mice. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes Cellular and molecular basis of beta-amyloid precursor protein metabolism Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression. The EGF receptor - an essential regulator of multiple epidermal functions Common side effects of anti-EGFR therapy: acneform rash Targeting epidermal growth factor receptor signaling in the treatment of head and neck cancer
author name string	wds:Q28585864-1A3B293E-BD03-4083-B3F3-7ABD296BA00B wds:Q28585864-1AE70E89-8E07-4642-A31B-DB3B75BE0135 wds:Q28585864-74AACCE2-BF50-47D6-BCD0-BBFC1855A636 wds:Q28585864-8E6FFC09-3774-483F-8D79-FD71BB5B3E1A wds:Q28585864-B36EF2AF-5929-4463-9B74-D2C23B614A22 wds:Q28585864-C6654D7B-CD7B-412D-9E8A-BD5D5A86ED66
OpenCitations bibliographic resource ID	wds:Q28585864-9B4656DC-FE2B-4F5E-B7DC-0AB4D8A4685F
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/3896001

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