About: Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

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About: Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern Goto Sponge NotDistinct Permalink

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rdf:type	Item
description	artículu científicu espublizáu en 2000 (ast) vědecký článek publikovaný v roce 2000 (cs) наукова стаття, опублікована в лютому 2000 (uk) 2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած (hyw) 2000 թվականի փետրվարին հրատարակված գիտական հոդված (hy) im Februar 2000 veröffentlichter wissenschaftlicher Artikel (de) wüsseschaftlicher Artikel, wo im Hornig 2000 veröffentlicht worden isch (gsw) article scientifique publié en 2000 (fr) vedecký článok (publikovaný 2000/02/07) (sk) مقالة علمية (نشرت في 7-2-2000) (ar) scientific journal article (en) wetenschappelijk artikel (gepubliceerd op 2000/02/07) (nl)
publication date	wds:Q28510640-BCF71D48-52D4-4089-8D19-EF609B589A12
publication date	2000-02-07 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28510640-EB369F6B-1998-43C0-B06E-BE97CBD698AD
language of work or name	English
cites work	wds:Q28510640-07BF34F5-C75E-4069-8991-75277E27FCCF wds:Q28510640-09A992E4-D01B-4DF9-B375-2F8C7E22CFF5 wds:Q28510640-1C27185A-14F8-4B46-ADF7-6A1CB785E989 wds:Q28510640-2392CB7A-2FF0-46FA-9305-ED3254B25197 wds:Q28510640-2CD912E5-6CB4-4584-8165-D761E2B74919 wds:Q28510640-402E972F-78F3-4666-8812-F3846EE4E2B2 wds:Q28510640-417742AE-8F67-4212-8A0E-0EAFF63C2CE2 wds:Q28510640-5223056C-3DEE-4E45-BB1F-9C3061D773AA wds:Q28510640-5CDA1D2A-EEE9-4FC0-AAA5-60BC8BAE45F6 wds:Q28510640-628B8089-B8B0-4DEA-B4FC-A0D3819A67C9 wds:Q28510640-64D5A1FD-E83A-48B4-82AA-0F611370E5C1 wds:Q28510640-6F380124-2C55-48F1-84CD-E559C2AD633A wds:Q28510640-747C625A-DBA9-4A1A-AD0F-377B4DC4E0BE wds:Q28510640-79114546-E205-426E-8805-A71BE8C86A2D wds:Q28510640-7ACC36EB-DA40-4219-95A9-93DA027580BA wds:Q28510640-88AEBBAE-6739-4644-9E67-7851A1B0518C wds:Q28510640-8B56423E-0A49-46F5-903A-62B2DFA0AED9 wds:Q28510640-8E0578D1-82FE-4060-9990-726D38878FB5 wds:Q28510640-8E9F802C-F694-4612-AA59-95AA8BD1E8BB wds:Q28510640-939B9BA8-360D-4E06-997E-23E7D38FD3C9 wds:Q28510640-A6B52EC5-13B9-449E-8BBA-698C4FF42CF1 wds:Q28510640-B0348279-7AC7-47AA-A515-463CC413A4CE wds:Q28510640-B1BF9828-4EA6-4B35-9EA0-3FDBAB72A9D7 wds:Q28510640-B21FFDC5-AD1E-4B44-85BF-8DFC6F6B6E9F wds:Q28510640-B2919171-FCA2-4A04-9A3F-13302BA1FB35 wds:Q28510640-B80E0FAC-A4B9-4657-8F98-4E655E4A25E3 wds:Q28510640-C5A338E2-165B-45A8-8C98-9B47D317F661 wds:Q28510640-E104D1C7-CBF1-4708-A93F-554896071B66 wds:Q28510640-F0CB3E91-05DA-45DD-B45F-77E5502A4EDE wds:Q28510640-F2A8D349-C2C8-470F-99FE-B282F24BCBC3 wds:Q28510640-F537CDA3-4163-4932-BC72-86B1E6742444 wds:Q28510640-F5F1AD66-D2D1-4746-A8C5-D4D2E5E5F08C
cites work	Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice Stepwise intraclonal maturation of antibody affinity through somatic hypermutation The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells Biochemistry and genetics of eukaryotic mismatch repair In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line Mechanisms and biological effects of mismatch repair Mutation in the mismatch repair gene Msh6 causes cancer susceptibility Both DNA strands of antibody genes are hypermutation targets Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2 An immunoglobulin mutator that targets G.C base pairs Mismatch repair co-opted by hypermutation. Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human VHDJH rearrangements Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications The role of DNA repair in somatic hypermutation of immunoglobulin genes Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein Evolution of somatic hypermutation and gene conversion in adaptive immunity Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process Severe attenuation of the B cell immune response in Msh2-deficient mice Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. PMS2-deficiency diminishes hypermutation of a lambda1 transgene in young but not older mice Amino acid insertions and deletions contribute to diversify the human Ig repertoire Somatic hypermutation and the three R's: repair, replication and recombination
author name string	wds:Q28510640-4EE26FE2-0F2B-4FDC-A593-CBAE475A3E37 wds:Q28510640-62F51634-4F72-45C5-90DA-D190163F4811 wds:Q28510640-ADF43429-16F3-4DAC-BEA4-EBFDA5E344BE wds:Q28510640-EE6379A8-38ED-4D14-82C9-92AEE6FF9AB3
OpenCitations bibliographic resource ID	wds:Q28510640-91146030-8EAD-4DFE-B7FD-7EC7DCEE3987
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/2948360
author name string	W. Edelmann M. D. Scharff M. Wiesendanger B. Kneitz
OpenCitations bibliographic resource ID	2948360
rdfs:label	Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern (en) Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern (nl) Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern (ast)
skos:prefLabel	Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern (en) Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern (nl) Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern (ast)
name	Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern (en) Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern (nl)

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