About: Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

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About: Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting Goto Sponge NotDistinct Permalink

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scientific journal article

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rdf:type	Item
description	artículu científicu espublizáu en 1998 (ast) vědecký článek publikovaný v roce 1998 (cs) 1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած (hyw) наукова стаття, опублікована в липні 1998 (uk) 1998 թվականի հուլիսին հրատարակված գիտական հոդված (hy) مقالة علمية (نشرت في يوليو 1998) (ar) vedecký článok (publikovaný 1998/07/01) (sk) article scientifique publié en 1998 (fr) wetenschappelijk artikel (gepubliceerd op 1998/07/01) (nl) scientific journal article (en) im Juli 1998 veröffentlichter wissenschaftlicher Artikel (de)
publication date	wds:Q28506440-BF207908-AE88-489D-962F-B0AC46B7CD5E
publication date	1998-07-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q28506440-A7BB08B0-23A9-4271-AEB3-8B7F41D1FA58
language of work or name	English
cites work	wds:Q28506440-02F3AEC4-3525-450A-BE8B-781365D66BDA wds:Q28506440-04EFC2AA-89EA-477B-99BB-DA1C538A8FE2 wds:Q28506440-170CF27A-A5BA-4BC5-94D9-A45E4E427A8D wds:Q28506440-24A1EA08-1772-405B-9CD5-5C5563D5242E wds:Q28506440-49B41AC6-A147-456A-B74E-B754957F3E59 wds:Q28506440-60D7ECEF-7E8D-42BE-B064-2E8FD27EC5B8 wds:Q28506440-63E87369-3B3D-48AE-915A-03E42E8BFEF9 wds:Q28506440-65843E9B-B33F-4BC3-827B-6439A46DEC91 wds:Q28506440-6676CCAA-EBC5-4DC5-B218-B63EE466BD69 wds:Q28506440-69559FCB-B868-477F-BE0D-9217FB82B12B wds:Q28506440-732D30B4-9174-4643-A6CD-7B67987B8DE6 wds:Q28506440-80A8E26C-2F7F-4053-9B5B-88F71643B6EF wds:Q28506440-9C597E61-9103-4775-BD54-28BEA3DE579E wds:Q28506440-AC396421-CD7C-4DFA-9633-63F11A60335B wds:Q28506440-B0B2115A-7452-41F1-87C4-6360CF5BA35F wds:Q28506440-C1DA5323-3809-47D6-9F31-5924B28C0574 wds:Q28506440-C827DE16-AFCD-460E-80F2-E55F4BE7B661 wds:Q28506440-C94A82AD-D103-4F8C-A620-890291830C2A wds:Q28506440-D668978B-BE28-4272-9912-9F2D257A7BA4 wds:Q28506440-E4A2618C-CFA0-4778-81E3-A0629DB128B8 wds:Q28506440-EB002752-6A54-49AE-BDFA-C6A2E777E8DD wds:Q28506440-F92F1535-40BC-4E42-AADB-1111BE63B31C
cites work	Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice A new DNA sequence assembly program Hyperresponsive B cells in CD22-deficient mice Clonal selection and learning in the antibody system The molecular basis of somatic hypermutation of immunoglobulin genes Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2 Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions Memory B cells at successive stages of differentiation. Affinity maturation and the role of IgD receptors Mutation drift and repertoire shift in the maturation of the immune response Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes. Mismatch repair co-opted by hypermutation. Age-related decrease in the proportion of germinal center B cells from mouse Peyer's patches is accompanied by an accumulation of somatic mutations in their immunoglobulin genes. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human VHDJH rearrangements
author name string	wds:Q28506440-1057F45E-3765-43E6-B6B1-E9AD0EA0D7C9 wds:Q28506440-C5A81455-70A2-4CB6-A1DA-355430C3B2D2 wds:Q28506440-C5AA957B-6C08-4A99-B96C-5D714C92E734 wds:Q28506440-D5DFCF5E-98A6-4DC5-8A39-279316297F88
OpenCitations bibliographic resource ID	wds:Q28506440-945195AF-BD03-43E6-A305-890FCE425800
OpenCitations bibliographic resource ID	https://w3id.org/oc/corpus/br/2948358
author name string	C. Milstein C. Rada M. R. Ehrenstein M. S. Neuberger
OpenCitations bibliographic resource ID	2948358
rdfs:label	Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting (en) Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting (nl) Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting (ast)
skos:prefLabel	Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting (en) Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting (nl) Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting (ast)
name	Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting (en) Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting (nl) Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting (ast)
title	wds:Q28506440-DCE08CBB-A26E-44E7-91D1-3D0B1659BDE5
title	Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting (en)
page(s)	wds:Q28506440-FE238EE5-C2AC-40E6-AA16-11CB1B9CF036
page(s)	135–141
instance of	wds:Q28506440-26B84FBD-A49F-4B05-9EFC-581B42503C41
instance of	scholarly article
main subject	wds:Q28506440-7A04F10A-E6B6-4A5B-9F72-B9DD72100616
main subject	MutS homolog 2
PubMed ID	wds:Q28506440-C54FF84C-0157-4C5C-9537-7CFE279BED8D
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9697843
PubMed ID	9697843
published in	wds:Q28506440-958E1C07-A48E-4879-BB80-A66082F88EA9
published in	Immunity
issue	wds:Q28506440-4C73CB13-1220-4151-8764-514B4D4101D5
volume	wds:Q28506440-6112D7A5-CC9E-4E2F-8A70-CB2B1AA4251C
issue	1
volume	9
DOI	wds:Q28506440-4FC282C1-FEE4-459B-B661-FDF328824989
DOI	http://dx.doi.org/10.1016/S1074-7613(00)80595-6
DOI	10.1016/S1074-7613(00)80595-6

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