About: Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I

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About: Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I Goto Sponge NotDistinct Permalink

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scientific article published on 01 June 1997

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в червні 1997 (uk) article scientifique publié en 1997 (fr) im Juni 1997 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en xunu de 1997 (ast) scientific article published on 01 June 1997 (en)
publication date	wds:Q73442739-A4C7E746-0150-4FF1-9702-8F432164BE95
publication date	1997-06-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73442739-BFEFC96D-D9A4-468B-BFE9-1DFDF673BBD6
language of work or name	English
cites work	wds:Q73442739-0217C525-27EB-438F-9992-7E6B148A6643 wds:Q73442739-08D2D6D1-CF84-43F6-B4AE-78D71CB033EF wds:Q73442739-0AC6D0D0-8031-4398-8D90-8F97BE204483 wds:Q73442739-0CB7DC40-F484-40FF-9CB4-2126095903F3 wds:Q73442739-146D304D-3185-4651-92B5-A5C3FDEFAC1C wds:Q73442739-1A638657-3039-4A55-9B43-F75551309D8B wds:Q73442739-1E8F0E1F-2FF4-420C-AFB5-53550256EB3B wds:Q73442739-210CF924-F492-4E01-A0AF-2573A1214E8B wds:Q73442739-214FE31A-E442-4F61-B95E-D4961514A43C wds:Q73442739-258224F0-1BD0-4ABD-8249-A56228151379 wds:Q73442739-27001D24-C994-4FF7-ACF2-762C380FF053 wds:Q73442739-304934EE-D1FA-4418-847D-3FDC6400854D wds:Q73442739-312938F9-9540-4043-BC17-CF6085680C5F wds:Q73442739-4C1195B2-F23D-4538-8DB3-CF9C91FD2F21 wds:Q73442739-5BBC03AC-272D-49A9-A1D8-042F6A8CC044 wds:Q73442739-7038D6F5-9343-48AD-87EB-ABA212DF4AD3 wds:Q73442739-712254B0-0679-4C7A-8E5E-DB3D71B9ED7B wds:Q73442739-72C541E0-F694-41FD-8711-A99A144193F0 wds:Q73442739-7329CB5D-B126-4EBA-BA34-3062466C9F0D wds:Q73442739-7394B51F-AAA5-48E9-B10E-13636DEEFB40 wds:Q73442739-89763D07-794C-4BD4-8616-E52994CF06D9 wds:Q73442739-8F053E20-7436-4CC5-961F-B227C9203FB4 wds:Q73442739-92CD6273-4C77-4735-8339-5AA8E49796F3 wds:Q73442739-98BB0C62-848F-4BB5-832E-E88769BF539B wds:Q73442739-9A705938-BB9D-43B9-8A9E-A1A4AA37F2FC wds:Q73442739-9BC5083A-31B3-4B52-B183-FB3738DD38A7 wds:Q73442739-A69B14DA-2A16-43EE-98FA-F79FCD847BDC wds:Q73442739-AD557A26-CE8B-4330-9453-A2DEAAFE8301 wds:Q73442739-B584137D-FBCE-4E57-98CB-8D49BF2541C4 wds:Q73442739-BAA0851A-BB0A-4B63-9D11-979E9A8F19B8 wds:Q73442739-BB7C0CAB-8939-41D9-ACE2-8FB35E004A8E wds:Q73442739-C5E65929-C137-444A-8F4E-DD9F186DABD3 wds:Q73442739-D03CCAB6-2D83-45B7-A1A4-7B72732A5843 wds:Q73442739-D6E2A3A4-3D0F-4147-8C52-2CD86A45C50C wds:Q73442739-E93E8EC9-674E-4D0A-800B-AD39D5B0AEE5 wds:Q73442739-EDF1E4D8-A567-4E98-922E-9EEC40AC69C8 wds:Q73442739-F38370E9-7B7E-4A0B-A463-BBDEB1F2E91C
cites work	Directed evolution of a protein: selection of potent neutrophil elastase inhibitors displayed on M13 fusion phage Potent and selective Kunitz domain inhibitors of plasma kallikrein designed by phage display Kinetics of the inhibition of thrombin by hirudin. The action of thrombin on peptide p-nitroanilide substrates. Substrate selectivity and examination of hydrolysis under different reaction conditions A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III. Glial-derived neurite-promoting factor is a slow-binding inhibitor of trypsin, thrombin, and urokinase Inhibitory mechanism of serpins. Interaction of thrombin with antithrombin and protease nexin 1 Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder Crystal and molecular structure of the bovine α-chymotrypsin-eglin c complex at 2.0 Å resolution Human plasma proteinase inhibitors Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins Refined 2.5 A X-ray crystal structure of the complex formed by porcine kallikrein A and the bovine pancreatic trypsin inhibitor. Crystallization, Patterson search, structure determination, refinement, structure and comparison with its [...] Crystal structure of an uncleaved alpha 1-antitrypsin reveals the conformation of its inhibitory reactive loop Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop Organization of serpin gene-1 from Manduca sexta. Evolution of a family of alternate exons encoding the reactive site loop Protein inhibitors of proteinases Natural protein proteinase inhibitors and their interaction with proteinases Identification of thrombin residues that modulate its interactions with antithrombin III and alpha 1-antitrypsin Divining the serpin inhibition mechanism: a suicide substrate 'springe'? Kinetics of suicide substrates. Practical procedures for determining parameters Inhibitory conformation of the reactive loop of alpha 1-antitrypsin The contribution of the conserved hinge region residues of alpha1-antitrypsin to its reaction with elastase Changing the inhibitory specificity and function of the proteinase inhibitor eglin c by site-directed mutagenesis: functional and structural investigation Met 358 to Arg mutation of alpha 1-antitrypsin associated with protein C deficiency in a patient with mild bleeding tendency Localization of the heparin-binding site of glia-derived nexin/protease nexin-1 by site-directed mutagenesis Role of the P2 residue in determining the specificity of serpins Development of a novel recombinant serpin with potential antithrombotic properties Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis. Conversion of alpha 1-antichymotrypsin into a human neutrophil elastase inhibitor: demonstration of variants with different association rate constants, stoichiometries of inhibition, and complex stabilities Site-directed mutagenesis of the P2 residue of human antithrombin Identification of lysines within alpha 1-antichymotrypsin important for DNA binding. An unusual combination of DNA-binding elements Interaction of activated protein C with serpins P1 variant antithrombins Glasgow (393 Arg to His) and Pescara (393 Arg to Pro) have increased heparin affinity and are resistant to catalytic cleavage by elastase. Implications for the heparin activation mechanism. Effect of alanine insertion (P'5) on the reactive centre of alpha 1-antitrypsin. Kinetic characterization of the proteinase binding defect in a reactive site variant of the serpin, antithrombin. Role of the P1' residue in transition-state stabilization of antithrombin-proteinase complex formation
author name string	wds:Q73442739-16E1FC28-A8F3-4403-87A4-A036200F40D9 wds:Q73442739-572429D6-5B72-4E85-90F4-F25C76EEE527
author name string	S R Stone M Z Djie
rdfs:label	Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I (en) Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I (nl)
skos:prefLabel	Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I (en) Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I (nl)
name	Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I (en) Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I (nl)
author	wds:Q73442739-BBF20012-FB3F-4949-9D6A-FFAD549AF840
author	Bernard Le Bonniec
title	wds:Q73442739-97F6321E-0FD6-4262-AE06-244D57936028
title	Intrinsic specificity of the reactive site loop of alpha1-antitrypsin, alpha1-antichymotrypsin, antithrombin III, and protease nexin I (en)
page(s)	wds:Q73442739-CFC3F96A-BA6E-4B06-BCF3-AB6DAB6E517A

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