About: Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors

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About: Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors Goto Sponge NotDistinct Permalink

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scientific article published on 01 June 1994

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в червні 1994 (uk) article scientifique publié en 1994 (fr) im Juni 1994 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en xunu de 1994 (ast) scientific article published on 01 June 1994 (en)
publication date	wds:Q72052703-86FBEA91-4CE3-4EE4-837E-BCAF7C958D47
publication date	1994-06-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q72052703-D8ACAEA1-8DF5-458D-8D1E-86CEF2B3FB36
language of work or name	English
author name string	wds:Q72052703-60116FC0-603B-4358-B8C1-873A9BE92958 wds:Q72052703-6DE4D390-F6A3-4972-B469-89FF3AB24213 wds:Q72052703-BF368E41-A029-4B25-8032-D2B784EFDC9F wds:Q72052703-C212BBBC-7CF7-4B31-AB2A-FE7ABD3411D1
author name string	D W Christianson R S Alexander A Jain G M Whitesides
rdfs:label	Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors (en) Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors (nl)
skos:prefLabel	Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors (en) Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors (nl)
name	Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors (en) Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors (nl)
title	wds:Q72052703-98393D5B-C091-4321-9F12-1B201F67A80E
title	Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors (en)
page(s)	wds:Q72052703-A034F883-F771-4E5B-B689-77A49FFF5C97
page(s)	2100-2105
instance of	wds:Q72052703-CED2D551-4F20-40E8-9BC7-C81D3096B600
instance of	scholarly article
PubMed ID	wds:Q72052703-F4B85BD1-2C7B-4F75-AEBA-30E4178186A5
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8027991
PubMed ID	8027991
published in	wds:Q72052703-BD045513-F7D0-466A-BB81-4E227747F2FD
published in	Journal of Medicinal Chemistry
issue	wds:Q72052703-7DAF8D4C-4C26-4AEF-ACF0-75EF318F5ACE
volume	wds:Q72052703-828EC4D0-190A-4C52-AFC6-5A22F24EA82B
issue	13
volume	37
DOI	wds:Q72052703-F58717F6-8D0A-4EB6-81D4-70C2C9238B9F
DOI	http://dx.doi.org/10.1021/JM00039A023
DOI	10.1021/JM00039A023
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q72052703
is cites work of	Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate Structural analysis of inhibitor binding to human carbonic anhydrase II Designing ligands to bind proteins DNA-templated organic synthesis and selection of a library of macrocycles Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase Structure and mechanism of carbonic anhydrase Combinatorial computational method gives new picomolar ligands for a known enzyme A paradigm for drug discovery employing encoded combinatorial libraries Carbonic anhydrase inhibitors — Part 29 1: Interaction of isozymes I, II and IV with benzolamide-like derivatives Dependence of Effective Molarity on Linker Length for an Intramolecular Protein−Ligand System Carbonic anhydrase inhibitors Catalytic and inhibitor-binding properties of some active-site mutants of human carbonic anhydrase I Carbonic anhydrase inhibitors - Part 49: Synthesis of substituted ureido and thioureido derivatives of aromatic/heterocyclic sulfonamides with increased affinities for isozyme I Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties Carbonic anhydrase activators: amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators Novel carbonic anhydrase isozymes I, II and IV activators incorporating sulfonyl-histamino moieties Carbonic anhydrase inhibitors. Part 43. Schiff bases derived from aromatic sulfonamides: towards more specific inhibitors for membrane-bound versus cytosolic isozymes Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties. Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails Thermodynamics of multivalent interactions: influence of the linker Amino Acids as Building Blocks for Carbonic Anhydrase Inhibitors Thermodynamic optimisation in drug discovery: a case study using carbonic anhydrase inhibitors Crystal analysis of aromatic sulfonamide binding to native and (Zn)2 adduct of human carbonic anhydrase I Michigan 1 Carbonic anhydrase inhibitors – Part 78. Synthesis of water-soluble sulfonamides incorporating β-alanyl moieties, possessing long lasting-intraocular pressure lowering properties via the topical route Carbonic anhydrase inhibitors. Part 79 Photo-Click-Facilitated Screening Platform for the Development of Hetero-Bivalent Agents with High Potency Molecular dynamics study of human carbonic anhydrase II in complex with Zn(2+) and acetazolamide on the basis of all-atom force field simulations
is cites work of	wds:Q27637428-1EC328E5-34DD-4B48-A29B-CD4DB420098A wds:Q24683205-403D51D7-5231-4292-BD63-769298A45B5E wds:Q36526030-B5BC786D-A240-4516-9765-ADC363BBE2D9 wds:Q42008430-7E08A461-D2BF-4A94-8F7D-97F6A302DD4C wds:Q43653122-E8E46908-D677-4875-8358-79D3BACBD62C wds:Q44011757-D79C472A-EBD1-4017-B36F-668E6095A45C wds:Q58863347-8DE40177-B5F7-4551-9258-C9A5A2ACC2CE wds:Q24318812-2DC40865-4C13-4A1D-8E3D-3C819E4062BC wds:Q34177745-2FD328D2-79B6-4B24-947D-BDD3106B8592 wds:Q58863339-71E06945-F034-4220-A8F9-3B6EB67A2BA9 wds:Q58863349-FAC9BACA-7AD8-4DA8-907F-2BD6C852D3CA wds:Q58863327-A6EAD326-1D9C-49CB-8DB2-BE97B9A103C8 wds:Q90725085-7E920919-DC4E-4D35-9AD4-38E1D8DBBE96 wds:Q27658036-724B2CA8-5BE3-4F5E-AFE5-EEA351E583E0 wds:Q44880159-A3974B68-3512-43AE-A36D-A93D0992B98E wds:Q58863350-E7C049EF-B6EB-4ACC-A7DB-60770001722A wds:Q24655457-461B3360-2783-4152-BDFF-272B78368B55 wds:Q37165654-AE97D84B-9216-4061-BB6D-9A1187BE6749 wds:Q58863345-247C9EE4-DCE5-471B-A236-09BC4E8E303A wds:Q58863359-08B85EE5-2A5D-44C5-81D8-E017B4B7F270 wds:Q88795745-42EA8281-4F6A-49B9-96FA-AB4AB864BA25 wds:Q29038357-B749FD3E-6D5B-49A0-AF1D-27CC8FBABD50 wds:Q28111928-765CF3ED-356D-4D0C-A668-3973C075B527 wds:Q27637537-E5C50E83-0224-4413-BAF9-31BDFD570F64

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