About: BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition

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About: BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition Goto Sponge NotDistinct Permalink

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scientific article published on 19 August 2020

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) artículu científicu espublizáu n'agostu de 2020 (ast) наукова стаття, опублікована 19 серпня 2020 (uk) scientific article published on 19 August 2020 (en)
publication date	wds:Q98573977-D794FAB9-73F2-437F-BC54-2F33F877B4F5
publication date	2020-08-19 00:00:00Z (xsd:dateTime)
cites work	wds:Q98573977-0BCCD191-4C82-4D3E-AC7F-1AC243EAAE25 wds:Q98573977-FEC79700-B666-4848-AB2A-58309A493C80
cites work	The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer
author name string	wds:Q98573977-1658A12B-ED6C-4F86-8DA5-C8BA2D0BC816 wds:Q98573977-1CC83657-8C16-402C-A579-95E9BE7AE216 wds:Q98573977-3F97CF5F-2A76-425A-B399-80C128E69044 wds:Q98573977-421BEF02-73BF-439B-BEC7-41D134E80A53 wds:Q98573977-434A5680-E663-443D-8229-B84D9F93A8A0 wds:Q98573977-68F5B136-96A2-4826-BE7A-D9170B5A71DA wds:Q98573977-72AE7228-6A9D-48B5-81FA-E37959699DC7 wds:Q98573977-77660882-6C0F-4091-9510-71A074ED4E9E wds:Q98573977-7EDAF02E-9B12-496A-A618-627F47B9D6A7 wds:Q98573977-8F0EC794-80C4-4934-A35D-22B20ECD0CC3 wds:Q98573977-95ED57B9-7061-4531-8CAE-EB64E8E791EC wds:Q98573977-A0D5BBA2-1014-4466-91F4-AD03B47280FD wds:Q98573977-B10D1BC8-7343-4A92-BA77-58F8E42F0BFC wds:Q98573977-B94206BE-A100-4128-AC53-494906790DD9 wds:Q98573977-C4DD89A6-CACF-4169-B0DB-3558BD4A6D95 wds:Q98573977-C8DED53F-FE88-47EC-8302-F4680BBCF5A9 wds:Q98573977-D03B170E-9E87-4039-BA13-7A8E6D5B9F57 wds:Q98573977-D47CFDE7-CAFA-4326-8789-5CA38CCA0B6D wds:Q98573977-ED3213FE-154E-4D56-9197-E35998C2456F wds:Q98573977-F3B2D7A9-C405-4FD2-9738-527A9506F4C7
author name string	Andreas Zoephel Mark Pearson Thomas Gerstberger Francesca Trapani Joseph R Marszalek Katharina Schipany Michael P Sanderson Christopher P Vellano Heribert Arnhof Michael Gmachl Klaus Rumpel Jonathan C O'Connell Dana-Adriana Botesteanu Fabio Savarese Simone Lieb Jurgen Moll Szu-Chin Fu Juergen Ramharter Nikolai Pototschnig Rachel L Mendes
rdfs:label	BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition (en) BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition (nl)
skos:prefLabel	BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition (en) BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition (nl)
name	BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition (en) BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition (nl)
author	wds:Q98573977-0C0F4467-6138-4113-A282-1A2F5A97EC8A wds:Q98573977-10681D8E-DD3D-459A-B98F-6291E8A0026E wds:Q98573977-265E0B36-B0D0-45F4-81E6-5D1D314A8427 wds:Q98573977-472D70EF-4135-43C3-B219-34F1854BAF3B wds:Q98573977-6EFDD581-7DA5-4293-860A-2FDF88479FE2 wds:Q98573977-73D55535-6A0E-4095-8BD6-323A29E1D8EA wds:Q98573977-83A4FC09-0FF8-42F6-834C-C1E70AC7BEDD wds:Q98573977-8F1C5682-B12D-418A-94E7-ACC43B201A66 wds:Q98573977-B1E419BC-6013-4FBC-8E17-D9BC3D593E2B wds:Q98573977-C8CA30F1-2DDD-49CD-A080-3B53792A6D24 wds:Q98573977-D74A2ED9-CD56-4433-9B12-C9D0C4D8D116 wds:Q98573977-E6CFD73D-623A-4FC5-B38F-6B089C9F4E3F wds:Q98573977-EFAE39CE-3A90-49EB-A0A4-5C85C36604EE
author	Daniel Gerlach Mark Petronczki Tim Heffernan Dirk Kessler Marco H Hofmann Jark Böttcher Peter Ettmayer Darryl B McConnell Franziska Schachinger Jessica Lf Teh Tobias Wunberg Norbert Kraut Christiane Kofink
title	wds:Q98573977-223BDFEE-2CC9-4B95-B4D3-BDEDEB9691EB
title	BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition (en)
instance of	wds:Q98573977-3FC2B2C2-F989-4E0B-8B7F-FB546E339655
instance of	scholarly article
PubMed ID	wds:Q98573977-B9BC5F5C-644B-4C55-AA7D-108DAAC1E715
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/32816843
PubMed ID	32816843
published in	wds:Q98573977-77607D9A-57A5-4935-AA9C-2EB16FD6E950
published in	Cancer Discovery
DOI	wds:Q98573977-C9928AB6-DF60-49BD-B1F9-AE16FF8A86A7
DOI	http://dx.doi.org/10.1158/2159-8290.CD-20-0142
DOI	10.1158/2159-8290.CD-20-0142
PMCID	wds:Q98573977-23A22809-6F34-4EAD-A35F-B1D1425A7305
PMCID	7892644
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q98573977
is cites work of	Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer Building towards Precision Oncology for Pancreatic Cancer: Real-World Challenges and Opportunities

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