About: Christopher P Austin

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An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

CEO-Partner, Flagship Pioneering

Attributes	Values
rdf:type	Item
description	CEO-Partner, Flagship Pioneering (en)
rdfs:label	Christopher P Austin (en) Christopher P Austin (nl)
skos:prefLabel	Christopher P Austin (en) Christopher P Austin (nl)
name	Christopher P Austin (en) Christopher P Austin (nl)
affiliation	wds:Q87934606-93480FE5-CF36-4D72-986B-3DD867F63A04
affiliation string	wds:Q87934606-1F24B260-ED42-472E-B939-8E96BDB147A1
LinkedIn personal profile ID	wds:Q87934606-AC1C1E74-ACBB-496A-92B7-7864CC91CB7C
affiliation	Flagship Pioneering
affiliation string	Flagship Pioneering
LinkedIn personal profile ID	christopher-austin-b23b43128
given name	wds:Q87934606-A83A6D53-81B7-4FB3-B2C1-E02753986C8E
given name	Christopher
image	wds:Q87934606-002101A3-0122-401B-A701-B0F1BA663CC0
instance of	wds:Q87934606-0206E8FE-5655-487F-8B63-6101A68BE5BB
described at URL	wds:Q87934606-21EFD683-9D90-436A-BFDC-254FA9A879DE
image
instance of	Homo sapiens
described at URL	https://www.flickr.com/photos/64860478@N05/33301561876
award received	wds:Q87934606-9247DE3C-D393-49F8-99C1-D86452A8DFA3
award received	Fellow of the American Association for the Advancement of Science
Commons category	wds:Q87934606-B0E978AE-C782-4AB6-937B-046C16D362F7
Commons category	Christopher P. Austin
skos:altLabel	Christopher Austin (en) Chris Austin (en) Christopher P. Austin (en)
employer	wds:Q87934606-488C1C5C-E1E1-4C9F-9458-BE4942CB1294 wds:Q87934606-4AD6C962-F4A2-4E9D-9134-44FA4B424C34 wds:Q87934606-7E93670A-88D4-4639-B0FD-EB75A28ED788
participant in	wds:Q87934606-A722330C-B55B-4B7E-9365-2C79EB2AA385 wds:Q87934606-B74A5AD6-E76E-4633-80F4-83E9A623510F
sex or gender	wds:Q87934606-72A30B30-5AAC-47F9-850A-322DB699621A
family name	wds:Q87934606-5DF3EB10-8669-47C7-893F-DC7B4317A840
employer	National Institutes of Health Flagship Pioneering Merck & Co.
participant in	Future of Health Summit 2022 Global Conference 2022
sex or gender	male
family name	Austin
is owl:sameAs of	Christopher P Austin Christopher P Austin
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q87934606 Category:Christopher P. Austin
is author of	Compound Management for Quantitative High-Throughput Screening Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification Prepublication data sharing Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase Multi-gram scale synthesis of FR180204. Are hERG channel blockers also phospholipidosis inducers? Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research Monitoring compound integrity with cytochrome P450 assays and qHTS. Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB Characterization of chemical libraries for luciferase inhibitory activity Identification of oxadiazoles as new drug leads for the control of schistosomiasis Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis A high-throughput screen for aggregation-based inhibition in a large compound library. Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells Structure based model for the prediction of phospholipidosis induction potential of small molecules A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action A high-throughput approach for identification of novel general anesthetics Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs Identification of repurposed small molecule drugs for chordoma therapy. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1 High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis Compound cytotoxicity profiling using quantitative high-throughput screening A class of tricyclic compounds blocking malaria parasite oocyst development and transmission Identification of clinically used drugs that activate pregnane X receptors Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening A high-throughput screening assay for determining cellular levels of total tau protein A dual-fluorescence high-throughput cell line system for probing multidrug resistance The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential Improving the human hazard characterization of chemicals: a Tox21 update A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution Fluorescence spectroscopic profiling of compound libraries Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

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