About: Hirokazu Tamamura

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An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

Japanese pharmacologist

Attributes	Values
rdf:type	Item
description	연구원 (ko) дослідник (uk) изилдөөчү (ky) Japanese pharmacologist (en) Japans farmacoloog (nl) farmacólogo japonés (es) farmacólogu xaponés (ast) عالم صيدلية ياباني (ar) 日本の薬学者 (ja) Japanese pharmacologist (en-ca) Japanese pharmacologist (en-gb)
rdfs:label	Hirokazu Tamamura (en) Hirokazu Tamamura (nl) Hirokazu Tamamura (sq) Hirokazu Tamamura (tr) Hirokazu Tamamura (ast) 玉村啓和 (ja) 다마무라 히로카즈 (ko)
skos:prefLabel	Hirokazu Tamamura (en) Hirokazu Tamamura (nl) Hirokazu Tamamura (sq) Hirokazu Tamamura (tr) Hirokazu Tamamura (ast) 玉村啓和 (ja) 다마무라 히로카즈 (ko)
name	Hirokazu Tamamura (en) Hirokazu Tamamura (nl) Hirokazu Tamamura (sq) Hirokazu Tamamura (tr) Hirokazu Tamamura (ast) 玉村啓和 (ja) 다마무라 히로카즈 (ko)
affiliation	wds:Q86902683-0a0c1913-4c0b-fb79-8348-cacd4ef4ca01 wds:Q86902683-a8196030-4633-36e6-d87f-958caae121b4
affiliation	Kyoto University Tokyo Medical and Dental University
given name	wds:Q86902683-796ad7b8-4b83-18e9-a8c3-130eeb6ddca6
given name	Hirokazu
instance of	wds:Q86902683-72583B6E-646D-49A8-9624-61BA9D721726
instance of	Homo sapiens
skos:altLabel	Tamamura Hirokazu (en)
occupation	wds:Q86902683-E2D80411-D52E-45AA-B790-D30FCFF69A45 wds:Q86902683-decd9760-414c-a9cf-85ba-5512b0e540e7
languages spoken, written or signed	wds:Q86902683-c1ca7164-452d-4e12-95ee-821fb84e1ecd
name in native language	wds:Q86902683-258520ca-4a28-0444-d62c-89f2015caebb
sex or gender	wds:Q86902683-d4cf1fea-4a05-a84e-1b0c-7c8bc537bb38
country of citizenship	wds:Q86902683-30611259-477b-5da7-8ac1-36ef0d4aefe8
educated at	wds:Q86902683-3e8c79c4-43cf-d550-2176-665992be674c
family name	wds:Q86902683-0be4bf7a-4a18-3911-931a-16a05abb8c8d
occupation	pharmacologist researcher
languages spoken, written or signed	Japanese
name in native language	玉村啓和 (ja)
sex or gender	male
country of citizenship	Japan
educated at	Kyoto University
family name	Tamamura
ORCID iD	wds:Q86902683-44B1185B-0BD0-425C-85A3-377A8328F673
ORCID iD	https://orcid.org/0000-0003-2788-2579
ORCID iD	0000-0003-2788-2579
is owl:sameAs of	Hirokazu Tamamura
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q86902683
is author of	Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers. T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury. HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists Development of a 111In-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors Involvement of CD44 in induction of matrix metalloproteinases by a COOH‐terminal heparin‐binding fragment of fibronectin in human articular cartilage in culture A new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptor HIV-1 gp120 enhances giant depolarizing potentials via chemokine receptor CXCR4 in neonatal rat hippocampus. Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells CD4 mimics targeting the mechanism of HIV entry Small molecular CD4 mimics as HIV entry inhibitors Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis Rapid hematopoietic progenitor mobilization by sulfated colominic acid Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation. Fluorogenically active leucine zipper peptides as tag-probe pairs for protein imaging in living cells Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs. Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent. Two orthogonal approaches to overcome multi-drug resistant HIV-1s: development of protease inhibitors and entry inhibitors based on CXCR4 antagonists CXCR4 engagement promotes dendritic cell survival and maturation Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds. Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells The involvement of stromal derived factor 1alpha in homing and progression of multiple myeloma in the 5TMM model.

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