About: Elevated Expression and Pro-Inflammatory Activity of IL-36 in Patients with Systemic Lupus Erythematosus

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About: Elevated Expression and Pro-Inflammatory Activity of IL-36 in Patients with Systemic Lupus Erythematosus Goto Sponge NotDistinct Permalink

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scientific article published on 27 October 2015

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) article scientifique publié en 2015 (fr) наукова стаття, опублікована в жовтні 2015 (uk) im Oktober 2015 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 27 October 2015 (en) artículu científicu espublizáu n'ochobre de 2015 (ast)
publication date	wds:Q86587416-46102A7A-4A18-4AC8-AEBE-106E5A00A42D
publication date	2015-10-27 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q86587416-374AFFD4-87DB-482A-A39F-7FA5AC536DCF
language of work or name	English
cites work	wds:Q86587416-02880B06-2857-4034-ACB8-F88632EB19CA wds:Q86587416-0DB8B9B7-5B97-4CCF-BCBD-AD93FA797C44 wds:Q86587416-163F284B-B3E4-49F4-97C2-2FE97B08129A wds:Q86587416-2192F7A4-515B-4FA9-B4F8-E347E7DE07DF wds:Q86587416-25D0CAE0-C365-4164-ADD5-3C6123D39A6A wds:Q86587416-26FE06E3-81E5-4630-AAA1-646F90655A80 wds:Q86587416-2802F532-FB6D-42AD-A3B8-02CBDD232B0B wds:Q86587416-2D7D1D82-E74E-488A-9475-6C42784F62C4 wds:Q86587416-34C81D71-6EF0-41D5-B414-E5B9CDC59A31 wds:Q86587416-3CEB1032-0AD0-463A-B431-5D9E745953DB wds:Q86587416-443E90AD-25C2-4011-A4FD-12E376180844 wds:Q86587416-4A259C29-FEFB-4490-9D08-AD1CC712C923 wds:Q86587416-4E510562-797C-4B82-B599-98B09E97A58A wds:Q86587416-54DED109-01FB-4DFE-A383-5E628A933513 wds:Q86587416-563D84AA-C2B1-4769-ADE4-75118848C04D wds:Q86587416-575134EA-CF10-48D1-A3AF-9733CB95753E wds:Q86587416-619F4264-B122-4F2F-B48B-8FB60CE77A5B wds:Q86587416-6A26D3E9-21DC-4D5C-91D3-02C51BDB2C41 wds:Q86587416-6D27CA2C-3BF3-4B03-9B10-E9E01B796552 wds:Q86587416-732D6CA4-484C-48DC-AF23-8853D895663F wds:Q86587416-83E82097-057D-4507-AF08-FAFE9BD565EE wds:Q86587416-9619B56E-765F-4706-9DAB-B53DD80678EA wds:Q86587416-A3EDFFF8-EBB1-4B6D-B3E5-668DE7497337 wds:Q86587416-A833C7AC-DC7F-4488-8303-2BB25363509B wds:Q86587416-B33263A9-3BF8-4345-AA87-FD71B97A1F6C wds:Q86587416-B3BFDA67-BC46-441A-8F9B-292A2E3EA73D wds:Q86587416-BE3E4BE6-EF4E-4B82-9832-012D03AC7662 wds:Q86587416-C044580B-8E2A-4981-98E1-E111C68A67C8 wds:Q86587416-C1BE332F-2C28-4946-BC33-F59D9D2B2AFF wds:Q86587416-C29059BF-F3A9-4614-AB8E-A4C1D988FD30 wds:Q86587416-C3B11F6F-C3AA-4936-9703-832617799DA2 wds:Q86587416-E45CF27C-76A9-4C20-807A-66ABE897470F wds:Q86587416-EE50AEE2-60D6-49EA-8B41-96DFE3A6AC9F
cites work	Pathogenesis of systemic lupus erythematosus Regulatory B cells in autoimmunity: developments and controversies. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients IL-36R ligands are potent regulators of dendritic and T cells Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk Annotating genes with potential roles in the immune system: six new members of the IL-1 family IL-36 in psoriasis. IL-1RL2 and its ligands contribute to the cytokine network in psoriasis. Decrease in proportion of CD19+ CD24(hi) CD27+ B cells and impairment of their suppressive function in Graves' disease The 1982 revised criteria for the classification of systemic lupus erythematosus Biology of IL-36 cytokines and their role in disease Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus. Four new members expand the interleukin-1 superfamily IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus. Cytokines as therapeutic targets in SLE. Inflammation: IL-36 has proinflammatory effects in skin but not in joints IL-10-producing regulatory B cells (B10 cells) in autoimmune disease CD24(hi)CD27⁺ and plasmablast-like regulatory B cells in human chronic graft-versus-host disease. IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells Serum levels of cytokines in systemic lupus erythematosus : Association study in a Chinese population. Interleukin-36α axis is modulated in patients with primary Sjögren's syndrome. Elevation of plasma interleukin-18 concentration is correlated with disease activity in systemic lupus erythematosus The novel cytokine interleukin-36α is expressed in psoriatic and rheumatoid arthritis synovium The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin. The severity of experimental arthritis is independent of IL-36 receptor signaling Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB.
author name string	wds:Q86587416-04B6C886-0A4E-46D8-A345-876655B0F2A2 wds:Q86587416-07CED4A3-ADBF-43BA-83F1-3D3BF1AD01BB wds:Q86587416-270BA90D-40AB-4EA2-ADA4-7E399E363D39 wds:Q86587416-29176C09-BFAA-4E27-961C-E5654858F032 wds:Q86587416-2A8886A2-6192-4ED3-A3BC-C9F256A9A187 wds:Q86587416-776BD31B-8E99-4703-A85C-E8954653EBD1 wds:Q86587416-A1DAD63E-67EF-4E34-A001-613076F7FF92
author name string	Christopher Wai Kei Lam Chun Kwok Wong Jie Dong Man Chu Zhe Cai Delong Jiao Ngar Woon Kam
rdfs:label	Elevated Expression and Pro-Inflammatory Activity of IL-36 in Patients with Systemic Lupus Erythematosus (en) Elevated Expression and Pro-Inflammatory Activity of IL-36 in Patients with Systemic Lupus Erythematosus (nl)
skos:prefLabel	Elevated Expression and Pro-Inflammatory Activity of IL-36 in Patients with Systemic Lupus Erythematosus (en) Elevated Expression and Pro-Inflammatory Activity of IL-36 in Patients with Systemic Lupus Erythematosus (nl)
name	Elevated Expression and Pro-Inflammatory Activity of IL-36 in Patients with Systemic Lupus Erythematosus (en) Elevated Expression and Pro-Inflammatory Activity of IL-36 in Patients with Systemic Lupus Erythematosus (nl)
author	wds:Q86587416-AFDDE93B-9E15-4365-A114-BD6BD572F2C5
author	Lai-Shan Tam
title	wds:Q86587416-FA0FCC98-EC12-4BA6-BEBE-9845E3024568

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