About: Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability

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About: Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability Goto Sponge NotDistinct Permalink

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scientific article published on 19 October 2010

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) article scientifique publié en 2010 (fr) наукова стаття, опублікована в жовтні 2010 (uk) scientific article published on 19 October 2010 (en) artículu científicu espublizáu n'ochobre de 2010 (ast)
publication date	wds:Q85226583-D8210F08-2EE1-4DE7-B19B-C9AB23D2A1FB
publication date	2010-10-19 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q85226583-2DF83ADF-EDB3-48C7-9B83-CE11E67573C5
language of work or name	English
author name string	wds:Q85226583-06999149-1D71-4C56-9B92-5AE83304EBB0 wds:Q85226583-240C2574-1284-46EF-8F2A-3C88453C68A8 wds:Q85226583-6C30C000-D0F1-4A5F-889C-D72A4AB8AA4C wds:Q85226583-B3553881-F40B-4973-98A5-3367E8D0D89A
author name string	Steven M Bishop Deborah S Goldberg Hasige A Sathish Ambarish U Shah
rdfs:label	Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability (en) Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability (nl)
skos:prefLabel	Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability (en) Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability (nl)
name	Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability (en) Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability (nl)
title	wds:Q85226583-CFBF1575-468A-41B1-BE1A-6D939DCF5970
title	Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability (en)
page(s)	wds:Q85226583-3697323D-42C4-444A-A80B-CE0F42228B66
page(s)	1306-1315
instance of	wds:Q85226583-A61547B6-A7FF-43E5-BE26-A0D365944FAC
instance of	scholarly article
main subject	wds:Q85226583-73E315BA-E8EA-4BCA-89CB-8C11EE50EAE4
main subject	monoclonal antibody
PubMed ID	wds:Q85226583-88758103-5B4B-423A-B7A7-38F61D6A91CC
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/20960568
PubMed ID	20960568
published in	wds:Q85226583-73EEA074-BAF4-41C6-A251-0E824F5406F9
published in	Journal of Pharmaceutical Sciences
issue	wds:Q85226583-37118680-4376-4791-8C20-6A76207F26E7
volume	wds:Q85226583-2C1006F8-A69B-427F-9DC5-FC2AB4B5183C
issue	4
volume	100
DOI	wds:Q85226583-063B2126-7573-4A03-B701-BF664DBAA2D8
DOI	http://dx.doi.org/10.1002/JPS.22371
DOI	10.1002/JPS.22371
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q85226583
is cites work of	With or without sugar? (A)glycosylation of therapeutic antibodies Generation and comparative characterization of glycosylated and aglycosylated human IgG1 antibodies RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity Impact of Mutations on the Higher Order Structure and Activity of a Recombinant Uricase Protein stability by number: high-throughput and statistical approaches to one of protein science's most difficult problems. Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression The effect of arginine glutamate on the stability of monoclonal antibodies in solution. Improved Stability of a Model IgG3 by DoE-Based Evaluation of Buffer Formulations Acetate- and Citrate-Specific Ion Effects on Unfolding and Temperature-Dependent Aggregation Rates of Anti-Streptavidin IgG1. A novel screening method to assess developability of antibody-like molecules High-throughput biophysical analysis of protein therapeutics to examine interrelationships between aggregate formation and conformational stability Effects of ionic strength and sugars on the aggregation propensity of monoclonal antibodies: influence of colloidal and conformational stabilities Early implementation of QbD in biopharmaceutical development: a practical example Utility of High Throughput Screening Techniques to Predict Stability of Monoclonal Antibody Formulations During Early Stage Development Multi-criteria manufacturability indices for ranking high-concentration monoclonal antibody formulations Orthogonal high-throughput thermal scanning method for rank ordering protein formulations Effect of Polysorbate 20 and Polysorbate 80 on the Higher-Order Structure of a Monoclonal Antibody and Its Fab and Fc Fragments Probed Using 2D Nuclear Magnetic Resonance Spectroscopy. Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterization Rapid and accurate in silico solubility screening of a monoclonal antibody library. Effects of subclass change on the structural stability of chimeric, humanized, and human antibodies under thermal stress Structural and functional comparison of SARS-CoV-2-spike receptor binding domain produced in Pichia pastoris and mammalian cells An Evaluation of the Potential of NMR Spectroscopy and Computational Modelling Methods to Inform Biopharmaceutical Formulations Effect of Linker-Drug Properties and Conjugation Site on the Physical Stability of ADCs An "Fc-Silenced" IgG1 Format With Extended Half-Life Designed for Improved Stability. Formulations That Suppress Aggregation During Long-Term Storage of a Bispecific Antibody are Characterized by High Refoldability and Colloidal Stability Orthogonal Techniques to Study the Effect of pH, Sucrose, and Arginine Salts on Monoclonal Antibody Physical Stability and Aggregation During Long-Term Storage Evaluation of fluorescent dyes to measure protein aggregation within mammalian cell culture supernatants. Conjugation of Emtansine Onto Trastuzumab Promotes Aggregation of the Antibody-Drug Conjugate by Reducing Repulsive Electrostatic Interactions and Increasing Hydrophobic Interactions Predictive Screening Tools Used in High-Concentration Protein Formulation Development. Dynamic Light Scattering of Biopharmaceutics-Can Analytical Performance Be Enhanced by Laser Power? Germinality does not necessarily define mAb expression and thermal stability High Performance Size Exclusion Chromatography and High-Throughput Dynamic Light Scattering as orthogonal methods to screen for aggregation and stability of monoclonal antibody drug products Room temperature intrinsic emission ratio of BSA correlates with percent aggregates during long-term storage
is cites work of	wds:Q30397166-F119CDB7-AFB3-4984-A5DF-FA21FB6540B7 wds:Q38876656-73C9186A-CA1B-45D3-B14D-E72C9F3A71BE wds:Q38812686-D0D72C59-8CD1-49D1-ADC0-0F4E048F3E26 wds:Q38808725-5B8D0277-4507-4B8E-ABBD-4F25CA1A1EE7 wds:Q41951670-1BC5D37D-B79A-413F-80B6-0DC5684BDDF7 wds:Q47902036-CE0A40EC-C26F-4C22-9B12-1794D5631F4C wds:Q89575954-37DE770B-D06C-437A-B936-1BDAD7F3E1FD wds:Q38055447-80822FEA-4E64-4757-B0F0-8E319C8DCC56 wds:Q43660922-756ED42B-FD5D-4E4E-B3EE-A393B16BBD3B wds:Q51516806-2446E04F-63FE-4FA5-AE8E-D029F9F78F3A wds:Q26996528-6AFA904D-F412-4FCE-9EFE-780D9B29F788 wds:Q36693770-CCB1854D-DA04-42FA-BA73-20AA82D42727 wds:Q90476000-6C08C74E-AA9D-4F93-B62F-0451FB1F03CC wds:Q36406538-52C1887C-58BA-4937-AD49-C4A038A267B3 wds:Q37318764-B1835126-9EEC-43D6-85FD-ADBD0CB8233D wds:Q38622959-A63CC97B-C978-4D56-BA64-52CD39A7141F wds:Q44588569-AEFCEF65-83A8-4558-8AE2-F53068799825 wds:Q91123559-0801D33B-DDB3-4A92-9D48-82725E889A6C wds:Q26830466-42BD9CDB-59F1-4BB1-AE34-2218A0517EAE wds:Q37865923-E0663F08-E649-47DE-ACFF-54A61FCE2809 wds:Q90294271-CC155B2D-E656-478A-9AED-4BB3021653A2 wds:Q92216145-B68F0596-DA17-4B97-84D8-C00416D83EBB

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