About: High-affinity, selective σ ligands of the 1,2,3,4-tetrahydro-1,4'-silaspiro[naphthalene-1,4'-piperidine] type: syntheses, structures, and pharmacological properties

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About: High-affinity, selective σ ligands of the 1,2,3,4-tetrahydro-1,4'-silaspiro[naphthalene-1,4'-piperidine] type: syntheses, structures, and pharmacological properties Goto Sponge NotDistinct Permalink

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scientific article published on 11 November 2011

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в листопаді 2011 (uk) scientific article published on 11 November 2011 (en) 2011 թվականի նոյեմբերի 11-ին հրատարակված գիտական հոդված (hy) artículu científicu espublizáu en payares de 2011 (ast)
publication date	wds:Q82470504-FA267445-38CC-4989-BCA7-D946E6D74EC6
publication date	2011-11-11 00:00:00Z (xsd:dateTime)
cites work	wds:Q82470504-03117A10-34AA-4BA2-A4C2-6B750AA148BA wds:Q82470504-038C4B40-CBDC-44BA-B465-E82FFB836989 wds:Q82470504-10A71D16-4D3B-4746-8FC4-AA9C91393CB5 wds:Q82470504-12D3D408-C2AC-4A7D-B704-42DD1BB1791D wds:Q82470504-1DA9AF5A-4691-42A2-B5AB-0AFBA7FA82B3 wds:Q82470504-1EF4779D-95BF-495F-A93B-C50C83D1B4EC wds:Q82470504-28D55F48-BAF0-44C3-A6A6-B9F52511403E wds:Q82470504-35E29C97-1C28-42F1-AA5F-491CB7DB009A wds:Q82470504-3CB7F57C-08AD-4EA1-87DF-BDB33DCE3959 wds:Q82470504-3F52985F-B418-4A2F-962E-874708A6E8BA wds:Q82470504-55BCF044-E0D0-44E0-B9C8-78178D4462A7 wds:Q82470504-6705DA6C-9582-418E-A329-87305CC9D731 wds:Q82470504-69351792-78C1-4568-BABD-6964EF4CCA28 wds:Q82470504-6A72F6F6-E220-490D-9029-21A8A8AAA4D6 wds:Q82470504-70B2A485-DA79-4B3F-A458-E616BC2C5327 wds:Q82470504-744FDFB9-D320-47FC-AE4A-B9DABE62197F wds:Q82470504-75269F8F-39FB-4894-A730-2BF32E2DDDE1 wds:Q82470504-7B0D2C92-9A4F-44BB-9A46-9F1666B947C0 wds:Q82470504-857D9648-9365-4696-ACCD-77D1103E22DC wds:Q82470504-8A093022-14C7-4F9F-868A-9537E4AB6657 wds:Q82470504-9FA96667-D8CE-4058-B08C-D71B6CFD3D9B wds:Q82470504-A62D1185-C51C-4B17-94E9-7693D621857B wds:Q82470504-AD08A3C8-B3D4-4B72-9B47-EA9A1DF90EC8 wds:Q82470504-AF7EDD21-412E-45FA-8426-83EB2D1A68D1 wds:Q82470504-B5B68835-62A5-470F-A7A0-4668931ACB83 wds:Q82470504-BC1ADB5F-6960-4369-9D77-1FA2D4607273 wds:Q82470504-BD367BB8-9FEA-4823-92FF-F8403D74D303 wds:Q82470504-BFADE4FE-4098-4488-BCB0-E86AFCF3070D wds:Q82470504-CD5C587A-C63D-41DD-985A-AE75EA98FE8E wds:Q82470504-DA7C0A49-69FC-4995-B6AA-BC40AEE0297B wds:Q82470504-E3036794-1C3D-4C0C-B4DD-606E9E472FD5 wds:Q82470504-E9FBD4F5-30A2-49C6-AA9D-C88C0ECDA0C9 wds:Q82470504-F2D76671-B430-46B3-8654-C1A4E19B488E wds:Q82470504-F3DB3DE4-EF30-42E2-AFA4-94F931FDA55E wds:Q82470504-FDC23412-E9D8-4D19-9460-E2F75F7D41BF
cites work	The pharmacology of sigma-1 receptors Pharmacology and therapeutic potential of sigma(1) receptor ligands Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Density Functionals with Broad Applicability in Chemistry A short history of SHELX Cloning and functional characterization of a sigma receptor from rat brain. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction High performance computational chemistry: An overview of NWChem a distributed parallel application Purification, molecular cloning, and expression of the mammalian sigma1-binding site A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions Silicon switches of marketed drugs Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1) Cloning and characterization of a mouse sigma1 receptor. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Ibogaine possesses a selective affinity for sigma 2 receptors Characterization of the binding of [3H](+)-pentazocine to sigma recognition sites in guinea pig brain Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology (R)-sila-venlafaxine: a selective noradrenaline reuptake inhibitor for the treatment of emesis Chemistry challenges in lead optimization: silicon isosteres in drug discovery Exploitation of silicon medicinal chemistry in drug discovery Silicon analogues of the retinoid agonists TTNPB and 3-methyl-TTNPB, disila-TTNPB and disila-3-methyl-TTNPB: chemistry and biology Action of (R)-sila-venlafaxine and reboxetine to antagonize cisplatin-induced acute and delayed emesis in the ferret. Sila-haloperidol, a silicon analogue of the dopamine (D2) receptor antagonist haloperidol: synthesis, pharmacological properties, and metabolic fate. Spiropiperidines as high-affinity, selective .sigma. ligands Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders Novel sigma receptor ligands. Part 2. SAR of spiro[[2]benzopyran-1,4'-piperidines] and spiro[[2]benzofuran-1,4'-piperidines] with carbon substituents in position 3. Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1. In vitro metabolism of haloperidol and sila-haloperidol: new metabolic pathways resulting from carbon/silicon exchange Novel Silicon-Containing Analogues of the Retinoid Agonist Bexarotene: Syntheses and Biological Effects on Human Pluripotent Stem Cells Silicon analogues of the nonpeptidic GnRH antagonist AG-045572: syntheses, crystal structure analyses, and pharmacological characterization Synthesis of bicyclic sigma receptor ligands with cytotoxic activity. Synthesis of spirocyclic sigma1 receptor ligands as potential PET radiotracers, structure-affinity relationships and in vitro metabolic stability Dancing of the second aromatic residue around the 6,8-diazabicyclo[3.2.2]nonane framework: influence on sigma receptor affinity and cytotoxicity. Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580. Conformational properties of six-membered heterocycles: accurate relative energy differences with DFT, the importance of dispersion interactions and silicon substitution effects.
author name string	wds:Q82470504-0197124E-2075-4DC2-A4EE-CA3111569609 wds:Q82470504-35368C51-C141-462C-9282-9F45D644D79F wds:Q82470504-389CD285-6F70-40F8-9DD9-3460AB8A7B59 wds:Q82470504-ACDE5198-D281-407C-92A9-1869F2615345 wds:Q82470504-BE6DFE97-8421-4DD2-ABE4-93DA1DFF10AF wds:Q82470504-C52CD960-C2C2-450C-902B-5B938C0FAC7B wds:Q82470504-C68E9738-C46A-46C3-A9E7-4CBDA2D11AEF wds:Q82470504-FF1AA8D3-DAA5-4A10-9FB4-2A8FD6667CCA
author name string	Markus Fischer Christian Burschka Barbara Müller Bernhard Wünsch Rüdiger Bertermann Steffen Dörrich Ingvar Arnason Géraldine Meyerhans
rdfs:label	High-affinity, selective σ ligands of the 1,2,3,4-tetrahydro-1,4'-silaspiro[naphthalene-1,4'-piperidine] type: syntheses, structures, and pharmacological properties (en) High-affinity, selective σ ligands of the 1,2,3,4-tetrahydro-1,4'-silaspiro[naphthalene-1,4'-piperidine] type: syntheses, structures, and pharmacological properties (nl)
skos:prefLabel	High-affinity, selective σ ligands of the 1,2,3,4-tetrahydro-1,4'-silaspiro[naphthalene-1,4'-piperidine] type: syntheses, structures, and pharmacological properties (en) High-affinity, selective σ ligands of the 1,2,3,4-tetrahydro-1,4'-silaspiro[naphthalene-1,4'-piperidine] type: syntheses, structures, and pharmacological properties (nl)
name	High-affinity, selective σ ligands of the 1,2,3,4-tetrahydro-1,4'-silaspiro[naphthalene-1,4'-piperidine] type: syntheses, structures, and pharmacological properties (en) High-affinity, selective σ ligands of the 1,2,3,4-tetrahydro-1,4'-silaspiro[naphthalene-1,4'-piperidine] type: syntheses, structures, and pharmacological properties (nl)

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