About: Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction Goto Sponge NotDistinct Permalink

An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

scientific article published on 17 November 2005

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) article scientifique publié en 2005 (fr) наукова стаття, опублікована в листопаді 2005 (uk) im November 2005 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 17 November 2005 (en) artículu científicu espublizáu en payares de 2005 (ast)
publication date	wds:Q81492019-94901CA5-1F0E-45F5-8043-40833BD7688E
publication date	2005-11-17 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q81492019-C3BEA056-D816-44BD-8D48-54FF0086C0AC
language of work or name	English
author name string	wds:Q81492019-05C02228-6E0F-4399-BD3D-75CB3D0BF84B wds:Q81492019-10A6D3F1-DF84-4681-B3E4-AE21AA42E90F wds:Q81492019-7E7CC540-215E-40C3-B40E-699F3A5A2FE7 wds:Q81492019-906E5C61-C1C3-4FD0-8911-6528850FF091 wds:Q81492019-B1A97A6B-1C16-4EDB-A952-25748B95F8B1 wds:Q81492019-D041772A-8013-427E-8ABA-7117C4F71E9C wds:Q81492019-EF3119AF-C149-427B-8C92-3C894A47A7C2 wds:Q81492019-F4E03D86-ECAF-49B2-97E5-B9498A363322
author name string	Thomas L Schwarz Jeanne M Nerbonne Haodong Xu Céline Marionneau Sophie Demolombe Kathryn A Yamada Weinong Guo W Edward Jung
rdfs:label	Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction (en) Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction (nl)
skos:prefLabel	Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction (en) Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction (nl)
name	Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction (en) Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction (nl)
author	wds:Q81492019-CEA343B9-94BD-459C-9716-12CEE585F19C
author	Franck Aimond
title	wds:Q81492019-083F3810-427F-4416-8C61-1BCDAD3FC3E1
title	Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction (en)
page(s)	wds:Q81492019-2453C43E-E9AE-46AA-BE40-8EEFE6E8AEAC
page(s)	1342-1350
instance of	wds:Q81492019-A73C32E5-7145-4A17-AF0B-344DD11B5636
instance of	scholarly article
PubMed ID	wds:Q81492019-EBF74145-38EC-4C8E-B3AE-5E5A32158396
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16293790
PubMed ID	16293790
published in	wds:Q81492019-52F9565F-734D-4C7A-B2F9-8A5834A907F0
published in	Circulation Research
issue	wds:Q81492019-A755BAC8-CFFF-4DDB-8FBC-7E914C6B9818
volume	wds:Q81492019-DE8FDB5D-43F6-49FE-B82E-37D18546196D
issue	12
volume	97
DOI	wds:Q81492019-0E2759F4-9CF0-48C6-B4F1-C555B6B27EA0
DOI	http://dx.doi.org/10.1161/01.RES.0000196559.63223.AA
DOI	10.1161/01.RES.0000196559.63223.AA
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q81492019
is cites work of	Transcriptional profiling of the human fibrillin/LTBP gene family, key regulators of mesenchymal cell functions. Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits Variability, compensation, and modulation in neurons and circuits Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation Alterations of A-type potassium channels in hippocampal neurons after traumatic brain injury Rapid, bidirectional remodeling of synaptic NMDA receptor subunit composition by A-type K+ channel activity in hippocampal CA1 pyramidal neurons Altered synaptic and non-synaptic properties of CA1 pyramidal neurons in Kv4.2 knockout mice A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons. Kv4.2 is a locus for PKC and ERK/MAPK cross-talk Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f) MicroRNA-301a mediated regulation of Kv4.2 in diabetes: identification of key modulators Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. Pore mutants of HERG and KvLQT1 downregulate the reciprocal currents in stable cell lines Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons. Compartmentalized dendritic plasticity and input feature storage in neurons Stabilization of Kv4 protein by the accessory K(+) channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K(+) currents Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts Manipulating Kv4.2 identifies a specific component of hippocampal pyramidal neuron A-current that depends upon Kv4.2 expression Mouse models of long QT syndrome Proteomic analysis highlights the molecular complexities of native Kv4 channel macromolecular complexes S3b amino acid substitutions and ancillary subunits alter the affinity of Heteropoda venatoria toxin 2 for Kv4.3. The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function Exercise training and PI3Kα-induced electrical remodeling is independent of cellular hypertrophy and Akt signaling MiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization Mutant analysis of the Shal (Kv4) voltage-gated fast transient K+ channel in Caenorhabditis elegans Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits Electrical remodelling maintains firing properties in cortical pyramidal neurons lacking KCND2-encoded A-type K+ currents Key factors in the discovery and development of new antiepileptic drugs On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools. KChIP2 attenuates cardiac hypertrophy through regulation of Ito and intracellular calcium signaling. Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus. Rapid homeostatic plasticity of intrinsic excitability in a central pattern generator network stabilizes functional neural network output. Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain. Transcriptional and electrophysiological consequences of KChIP2-mediated regulation of CaV1.2. Impact of KChIP2 on Cardiac Electrophysiology and the Progression of Heart Failure Accessory subunit KChIP2 modulates the cardiac L-type calcium current Deleting the accessory subunit KChIP2 results in loss of I(to,f) and increased I(K,slow) that maintains normal action potential configuration. The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.

Faceted Search & Find service v1.16.117 as of May 05 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of May 5 2024, on Linux (x86_64-centos_6-linux-gnu), Single-Server Edition (378 GB total memory, 180 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software