About: Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer

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About: Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer Goto Sponge NotDistinct Permalink

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scientific article published on 13 September 2006

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) article scientifique publié en 2006 (fr) наукова стаття, опублікована у вересні 2006 (uk) im September 2006 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 13 September 2006 (en) artículu científicu espublizáu en setiembre de 2006 (ast)
publication date	wds:Q80253632-6EF1A67C-E47C-4020-992F-B08F63F8E417
publication date	2006-09-13 00:00:00Z (xsd:dateTime)
exact match	wds:Q80253632-9CC9CDDF-07F1-41C5-A0C2-573A36CEE414
exact match	https://scigraph.springernature.com/pub.10.1007/s10637-006-9008-5
cites work	wds:Q80253632-0053F2F8-6E7B-489A-A104-ED4C6C210DA8 wds:Q80253632-0AEF9E9D-EBC5-46BF-A857-3500607BA8F7 wds:Q80253632-1AD50D12-0F1A-478C-BBA9-40B7002444CA wds:Q80253632-225733A9-8568-4F36-92B2-D4C15B67EF65 wds:Q80253632-278B84A4-0D37-48A9-BDDB-80A146F9DA17 wds:Q80253632-28ED20FC-BE9E-4F63-ACF9-F4798183C8E9 wds:Q80253632-42984761-2ED8-4E50-9343-055372F297D9 wds:Q80253632-42BC6FA8-E586-4441-A2D6-43EEDF434835 wds:Q80253632-450101A3-9162-491F-B0CA-B5A067B86597 wds:Q80253632-539CCFA4-6BAB-4A85-BAF9-175910167718 wds:Q80253632-54A2F863-05D5-4921-9D30-67111D200F7C wds:Q80253632-5B5845C7-F3ED-41DA-82D7-837F9E8947DD wds:Q80253632-7707F9B9-7DA9-4E66-AE10-F8E277EC4294 wds:Q80253632-792C6B97-C1B5-4DBD-AF00-481633F7F650 wds:Q80253632-7BFA416A-80C9-49CB-8C71-3F8576ED5665 wds:Q80253632-932CE262-E9AC-404E-978E-CD0692BC725E wds:Q80253632-96152C86-E2E6-4C25-BF50-2DE221918EDB wds:Q80253632-9CBA47BF-F1E6-4C29-8338-37F18761F2BE wds:Q80253632-A6B27021-E562-4255-A142-AE1837F6AAD6 wds:Q80253632-AF4CEDBF-4933-4ADB-BE5E-C9D3165A4913 wds:Q80253632-BA68980E-EBB1-47E7-923A-39A1BA4E8E66 wds:Q80253632-C66EFA7F-EF12-4C1E-B60E-68169CA5EBA3 wds:Q80253632-DA13D120-66D7-44AC-8FCF-B8FAEF6F3DA9 wds:Q80253632-DBF0ABEC-A3D1-41A5-A5B9-1D1076707CAE wds:Q80253632-E15921FE-F6B9-401C-82E2-0BC3A41C34D2 wds:Q80253632-EDA2BCAF-9AA9-4AFD-B494-B193803037F9 wds:Q80253632-FA084BF8-8BB9-4555-9CBF-E03AFF6F5247 wds:Q80253632-FE9EC507-C741-4833-965F-D85BC17FAD3B
cites work	Angiogenesis: A Marker for Neoplastic Transformation of Mammary Papillary Hyperplasia Suppression of type II collagen-induced arthritis by the endogenous estrogen metabolite 2-methoxyestradiol. Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma Carcinogenicity of catechol estrogens in Syrian hamsters What Is the Evidence That Tumors Are Angiogenesis Dependent? The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol Antiangiogenic activity of prostate-specific antigen Mechanism of action of 2-methoxyestradiol: new developments Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors Prognostic value of prostate-specific antigen for women with breast cancer: a large United States cohort study. A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis. 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression. Association of Tumor Angiogenesis With Bone Marrow Micrometastases in Breast Cancer Patients Uterine estrogen receptor binding of catecholestrogens and of estetrol (1,3,5(10)-estratriene-3,15α,16α,17β-tetrol) Association between tumour angiogenesis and tumour cell shedding into effluent venous blood during breast cancer surgery Tumor growth of FGF or VEGF transfected MCF-7 breast carcinoma cells correlates with density of specific microvessels independent of the transfected angiogenic factor Docetaxel administered on a weekly basis for metastatic breast cancer Angiogenesis induced by "normal" human breast tissue: a probable marker for precancer. Impact of Continuously Administered Catechol Estrogens on Uterine Growth and Luteinizing Hormone Secretion* Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines. The prognostic value of angiogenesis by Chalkley counting in a confirmatory study design on 836 breast cancer patients Enhanced prediction of breast cancer prognosis by evaluating expression of p53 and prostate-specific antigen in combination. An investigation of the relationship between estrogen, estrogen metabolites and blood cholesterol levels in ovariectomized rats.
author name string	wds:Q80253632-0FF7CF57-F867-453E-9B27-F05F10842821 wds:Q80253632-367893BA-D50F-4C0A-A7AA-B9A1B4714E61 wds:Q80253632-3B69D843-A755-4776-8627-FCC5FDF0A74E wds:Q80253632-9CEE8038-5DFA-452C-845D-41D8E3389B13 wds:Q80253632-B505954B-0BF1-4283-9E48-1F20B5036EE2
author name string	Daryl J Murry Anna Maria Storniolo Carolyn Sidor Anthony M Treston Jehana James
rdfs:label	Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer (en) Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer (nl)
skos:prefLabel	Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer (en) Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer (nl)
name	Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer (en) Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer (nl)
author	wds:Q80253632-526E0826-1CE0-44DB-9583-965C1A204B4B wds:Q80253632-91B044F6-2853-46DC-BB7D-CA20060867AC
author	Kathy D. Miller George Sledge
title	wds:Q80253632-BA803821-0B4B-41B4-9B0D-9FDD90005653
title	Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer (en)
page(s)	wds:Q80253632-23005F71-1102-4810-9B61-A031045EACA6
page(s)	41-48
instance of	wds:Q80253632-7CB7C836-130E-40E4-BEE3-8A1A39BFA2B2
instance of	scholarly article
main subject	wds:Q80253632-62F4820F-604E-41F1-B996-5D14A0ADCE12 wds:Q80253632-7E59D3C0-292D-4BF3-81F9-6B0D04149D6E wds:Q80253632-FFDA04AB-2234-44BF-9622-9B6AA9088BD6
main subject	wd:Q420436 wd:Q4596897 metastatic breast cancer
PubMed ID	wds:Q80253632-8E6B5DF0-3F91-418A-A1F3-5F497814C990

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