About: Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs

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About: Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs Goto Sponge NotDistinct Permalink

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scientific article published on 15 February 2007

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в лютому 2007 (uk) article scientifique publié en 2007 (fr) im Februar 2007 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 15 February 2007 (en) artículu científicu espublizáu en febreru de 2007 (ast)
publication date	wds:Q79987953-D08F9DB1-C24D-4BBE-A6C6-4E24DA0B8FAC
publication date	2007-02-15 00:00:00Z (xsd:dateTime)
cites work	wds:Q79987953-004AFE2C-7ED1-4030-9DFC-5388E6B92620 wds:Q79987953-027592EF-C2C3-49EB-845E-FE37A02AF24C wds:Q79987953-0EF170AF-7EAD-47D0-92C2-7A38D8456854 wds:Q79987953-1250B1AB-5353-4E66-A2E1-0B080B3B6A8B wds:Q79987953-1498E138-C484-44A3-BD1C-9696F9DDC02D wds:Q79987953-172B9DB4-FC75-44C8-9AA0-46EE86575739 wds:Q79987953-19593916-F670-473C-B09E-42838452A67F wds:Q79987953-1988CB4D-5E03-43E9-97E1-6CAB8E6AF899 wds:Q79987953-1BE8D9EF-944E-4AC5-AD11-0EF784BB013B wds:Q79987953-241DF823-C195-47B8-94C9-42894AD634CB wds:Q79987953-29A38AF2-F97A-4BC0-89CF-328169C5AFEE wds:Q79987953-29E8F38E-EAB8-43FF-AFBA-449E64DA6C2A wds:Q79987953-2BAB5529-7911-4C37-87C5-6EC8D0B1D4F2 wds:Q79987953-2F4DBB06-0D90-43BB-9CF3-6788DDFEC3BD wds:Q79987953-3598B749-A18F-4A4B-AE86-82EDE374497D wds:Q79987953-3E84E3C2-B80F-4E4A-94A4-C9EE8D1ED2CD wds:Q79987953-450EAF47-498D-4A68-8526-D15FE44AACDB wds:Q79987953-4B680761-7002-4D85-A026-378572C95B9C wds:Q79987953-4BFD98A4-BDDC-4937-91F8-A49F0478AEFD wds:Q79987953-4C7A2CE3-4070-4B8D-BFDC-34C4E15E1B17 wds:Q79987953-5D31CE85-D873-4802-AB83-B8FB14488287 wds:Q79987953-619F2AA0-315C-4FF7-9C41-3EEDAA9A1ABB wds:Q79987953-790D1BFF-710E-4A45-AD5E-F232E9573ABD wds:Q79987953-802B2BB7-4808-47A1-9D17-769CE2093AAC wds:Q79987953-81E1BB9B-1752-45A9-B0EB-581B6FD8E37D wds:Q79987953-93967BE4-9ABB-483C-8116-0EA2CF6A58D6 wds:Q79987953-A8F684F3-6F69-4E6F-8015-79A9ECA8D899 wds:Q79987953-B4018455-9984-493C-90BA-41E7AF29C7B4 wds:Q79987953-C336DBD6-CA31-4205-B02E-1742D0780F4D wds:Q79987953-C4CA769E-DDC9-426E-93BD-379FBB137B7C wds:Q79987953-C4D135CF-5811-441A-ABAD-3810AC581F03 wds:Q79987953-C8CBCE31-31F0-41D8-82F9-2DF5A88BBD26 wds:Q79987953-CAEEC109-F163-428A-99C7-2EF6E157B7A5 wds:Q79987953-D4F47BE6-B01F-40AC-9187-09010C3838B2 wds:Q79987953-D594AFE7-6D8E-4DA7-B6B6-F2693442D190 wds:Q79987953-D5EA2D2D-9F75-4228-9353-8FD29E8BEC3D wds:Q79987953-DB23296C-FA09-443D-A0AB-D77BEC1842DE wds:Q79987953-EDBA5D87-7ADB-42C3-B988-2448559FEE9B wds:Q79987953-EFD2A78A-CFC9-4B82-83AC-C06224A96A5B wds:Q79987953-F2435870-3754-45B9-9E7D-42AA577A83C7 wds:Q79987953-F4D04952-8D5E-465A-8406-70DE7D0A5F8E
cites work	Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound Measurement of the 'spontaneity' of self-emulsifiable oils Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain lipid-based microemulsion formulation. In vitro assessment of oral lipid based formulations Separation and characterization of the colloidal phases produced on digestion of common formulation lipids and assessment of their impact on the apparent solubility of selected poorly water-soluble drugs. Probing drug solubilization patterns in the gastrointestinal tract after administration of lipid-based delivery systems: a phase diagram approach. A new self-emulsifying formulation of itraconazole with improved dissolution and oral absorption In vitro model for ciclosporin intestinal absorption in lipid vehicles Enhanced absorption of indomethacin after oral or rectal administration of a self-emulsifying system containing indomethacin to rats Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor Evaluation of the in-vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products Examination of the impact of a range of Pluronic surfactants on the in-vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects Solubilization and wetting effects of bile salts on the dissolution of steroids Characterisation and quantification of medium chain and long chain triglycerides and their in vitro digestion products, by HPTLC coupled with in situ densitometric analysis. A dynamic in vitro lipolysis model. II: Evaluation of the model Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols A dynamic in vitro lipolysis model Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings Use of a dynamic in vitro lipolysis model to rationalize oral formulation development for poor water soluble drugs: correlation with in vivo data and the relationship to intra-enterocyte processes in rats Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs Preparation and in vitro evaluation of self-microemulsifying drug delivery systems containing idebenone The emulsification and solubilisation properties of polyglycolysed oils in self-emulsifying formulations Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions Aqueous lipid phases of relevance to intestinal fat digestion and absorption The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: studies with halofantrine. Relative bioavailability of danazol in dogs from liquid-filled hard gelatin capsules Molecular species of lecithins in human gallbladder bile Dose-dependent increase of saquinavir bioavailability by the pharmaceutic aid cremophor EL Enzymatic characterization of lipid-based drug delivery systems The self-emulsifying action of mixed surfactants in oil P-glycoprotein and surfactants: effect on intestinal talinolol absorption Effects of fasting on bile acid metabolism and biliary lipid composition in man Phase studies of mixed phosphated surfactants, n-hexane and water
author name string	wds:Q79987953-1AA33EFB-4DC1-4F8B-8467-6E92C0662441 wds:Q79987953-9975103F-D303-49E7-A3A4-79D0401297F0 wds:Q79987953-A980AD62-A252-4A4F-AA7D-13952AA1C66B
author name string	William N Charman Glenn A Edwards Jean F Cuiné
rdfs:label	Increasing the proportional content of surfactant (nl) Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs (en)
skos:prefLabel	Increasing the proportional content of surfactant (nl)

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