About: Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

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About: Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy Goto Sponge NotDistinct Permalink

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scientific article published on 01 January 1999

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в січні 1999 (uk) article scientifique publié en 1999 (fr) im Januar 1999 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en xineru de 1999 (ast) artikull shkencor i botuar më 01 janar 1999 (sq) scientific article published on 01 January 1999 (en)
publication date	wds:Q77932308-2F8FBAB2-3EE4-410A-ADBC-A6FE4CC345EF
publication date	1999-01-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q77932308-29E17127-A01C-4C49-9BA5-D765DA9F4B38
language of work or name	English
exact match	wds:Q77932308-CBBBCEEA-1D38-4032-84E3-877594221282
exact match	https://scigraph.springernature.com/pub.10.1038/sj.onc.1202314
cites work	wds:Q77932308-0A07CDE5-6581-4216-B57B-41285A59E1F8 wds:Q77932308-1F1B96D9-C99E-4B91-9FF7-177BDCAD7C88 wds:Q77932308-20AC6C98-202F-456A-8456-F1150F7C866E wds:Q77932308-2293A063-42BE-4139-A0C3-40EB162F5765 wds:Q77932308-23E5F46E-8DD6-4E52-8BBA-49F36ACCBB10 wds:Q77932308-2D252E9B-8634-45A0-90B6-AADA4973C912 wds:Q77932308-4411464D-1081-4185-A31E-AB10E8034F91 wds:Q77932308-4FC9B4AD-834D-462B-AAC8-54F32B95FEBE wds:Q77932308-50DB93C9-9996-4D12-9357-AE9395B54AFC wds:Q77932308-5D07904B-F09F-4DE7-95E2-4254681CA93C wds:Q77932308-61FB6DC4-5265-461C-A86D-CA4460B6697C wds:Q77932308-6D1BAFD7-2471-4893-B2B8-24B71C3FB483 wds:Q77932308-6EFE7F5B-FEA8-4028-9689-CF53CCC1430E wds:Q77932308-8183D030-4635-4989-97CF-73EBC893B327 wds:Q77932308-81AF4403-4CB1-4990-A2E3-5FB4EB5DB5F0 wds:Q77932308-8EC6F464-B41B-4C68-8872-477879D0F2BB wds:Q77932308-934300BD-83BC-402D-B3A8-8F4665EF3FD4 wds:Q77932308-9B52BDAC-25A3-4ED7-86E0-433E9FA300A2 wds:Q77932308-A0A6F336-E25B-4B61-8357-DA532ED40F96 wds:Q77932308-A78C653F-8EF9-42B6-9DA5-FA0F631B522D wds:Q77932308-B54CB341-AB02-4286-A07B-1AA0B4FB8257 wds:Q77932308-B8F47B2D-3396-454C-9A49-85BE11321179 wds:Q77932308-BD2F7C36-AF5A-446F-BFBA-DA13CB53FD41 wds:Q77932308-C0F70C31-F1D6-4F29-B9AA-383923A93BCB wds:Q77932308-C4669678-BAF8-485A-B49C-51F3DF519E6A wds:Q77932308-D41AE976-C59E-43B2-BBA2-7DE772E9E3A6 wds:Q77932308-D5785518-462A-4C7F-9ACA-970F3237F75A wds:Q77932308-DAF83B6E-A5FD-4B3D-ABDC-1CF83115B618 wds:Q77932308-E2252824-C6DD-4801-8DBF-EFD44AE451BC wds:Q77932308-E733C30F-84A3-438D-8B9B-A460C69F91AF wds:Q77932308-ED0D1A96-7413-4DF7-AB22-A386CAB1EF54 wds:Q77932308-FE9E41D9-1D24-459F-8ECF-EEF102BFD675
cites work	Apoptosis in cancer therapy: crossing the threshold TP53 mutations and breast cancer prognosis: particularly poor survival rates for cases with mutations in the zinc-binding domains. The p53 gene is a potent determinant of chemosensitivity and radiosensitivity in gastric and colorectal cancers p53, the cellular gatekeeper for growth and division p53 is required for radiation-induced apoptosis in mouse thymocytes Thymocyte apoptosis induced by p53-dependent and independent pathways. Transcriptional activation of the human epidermal growth factor receptor promoter by human p53. Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control p53 and treatment of bladder cancer Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells p53; from inductive signal to cellular effect Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene. Identification of a novel p53 functional domain that is necessary for efficient growth suppression Expression of apoptosis-regulatory genes in lung tumour cell lines: relationship to p53 expression and relevance to acquired drug resistance Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain Gain of function mutations in p53. Induction of cellular p53 activity by DNA-damaging agents and growth arrest. Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. p53 protein overexpression and chemosensitivity in breast cancer. Cancer therapy and p53. Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy Flexibility: the key to p53 function? Mutant p53 protein expression interferes with p53-independent apoptotic pathways. Apoptosis in antitumor strategies: modulation of cell cycle or differentiation. p53 mutations: gains or losses? Induction of apoptosis in HeLa cells by trans-activation-deficient p53. The polyproline region of p53 is required to activate apoptosis but not growth arrest. 'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain Ondansetron for intractable vertigo complicating acute brainstem disorders P53 gene alterations in human tumors: perspectives for cancer control. A mutant p53 antagonizes the deregulated c-myc-mediated enhancement of apoptosis and decrease in leukemogenicity
author name string	wds:Q77932308-4162B015-5D4D-4C39-B5D4-35101C5AE7CD wds:Q77932308-60F9AA57-73F5-47BA-B298-52C945048277 wds:Q77932308-7D2CD1C0-20B3-4BC1-BCC7-4124E8A3785D
author name string	A J Levine M Oren G Blandino
rdfs:label	Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy (en) Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy (nl) Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy (sq)
skos:prefLabel	Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy (en) Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy (nl) Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy (sq)
name	Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy (en) Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy (nl) Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy (sq)
title	wds:Q77932308-8ED89232-D1A6-43F8-8458-0F59E4E4CBF5
title	Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy (en)
page(s)	wds:Q77932308-8422B342-15D6-437F-990F-50E5ECE254CF
page(s)	477-485
instance of	wds:Q77932308-88C92F1E-12A8-477E-BA4B-9EFC889BA266
instance of	scholarly article
main subject	wds:Q77932308-352D69F1-FC7D-4CCF-9A13-D4CD4401AA32

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