About: Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment)

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About: Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment) Goto Sponge NotDistinct Permalink

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scientific article published on 01 January 1999

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в січні 1999 (uk) article scientifique publié en 1999 (fr) im Januar 1999 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en xineru de 1999 (ast) artikull shkencor i botuar më 01 janar 1999 (sq) scientific article published on 01 January 1999 (en)
publication date	wds:Q77896965-184BF16D-4C4F-4C2E-B69A-C712FF00C781
publication date	1999-01-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q77896965-9929CD8D-EF04-4E1F-AD43-E15D78F52EB0
language of work or name	English
cites work	wds:Q77896965-0B7AC4A1-BB50-40E7-9B01-D3A7DFD9A4E5 wds:Q77896965-1551F8E6-3758-4891-8CF7-4041F2B87C83 wds:Q77896965-207EBE1B-515E-4990-8E6C-A1690F589E60 wds:Q77896965-225924DF-FD1A-41E4-98BA-8F356FFD00DF wds:Q77896965-3528ED85-B2C0-4A8F-B725-AAD842EEB7C1 wds:Q77896965-352B2E09-A1F6-43B9-BD53-E3F7F3D00F29 wds:Q77896965-39D47676-839B-486A-9C67-9E59666CC054 wds:Q77896965-442E3F04-10D9-4A13-9711-F532404DAEEC wds:Q77896965-45252C1B-3C58-4185-9EB4-3DD8F44EC502 wds:Q77896965-4756E840-F898-410E-9DC5-5B562F206457 wds:Q77896965-5A11E27B-CD84-416A-AC6C-647935EF25AE wds:Q77896965-5A4BBB1D-1D7B-4D2C-80B8-B9757195093C wds:Q77896965-5BA55AE9-346B-4DE1-9EF1-5A5EC6F55FD0 wds:Q77896965-5D249187-9C71-48EA-8C3C-414105239128 wds:Q77896965-7C6B4549-3CC7-45F8-A7F2-0D367CC5BCF6 wds:Q77896965-8445A796-24C3-43A6-9B70-DB0F49F0D876 wds:Q77896965-852D96A7-3C9E-490B-84B1-67551AE28313 wds:Q77896965-85B7B199-AEEF-420F-8428-5023A5E69A75 wds:Q77896965-87321EFE-FB47-4F19-A3B0-EE62C452EA94 wds:Q77896965-A7539CF7-5038-49AF-896B-2732DF7D8BFB wds:Q77896965-B2715328-A656-4EEA-8991-7D4E9644BD89 wds:Q77896965-C3023104-51BF-4DD5-B4F1-7B395D0A9D23 wds:Q77896965-CD8AFD5B-D319-4BD3-BF4B-678C2E75311A wds:Q77896965-CDD5C63D-0C0C-4EC1-AB4D-3B6F1B0BA86C wds:Q77896965-CE8BE5BE-CB46-4D22-B78C-0B0065F060D5 wds:Q77896965-D00DB549-24D5-45F0-9B65-8514B66559DA wds:Q77896965-D49649D3-61C7-4415-B5F9-667C951BF304
cites work	Structure of Taq polymerase with DNA at the polymerase active site How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes. Structures of DNA and RNA polymerases and their interactions with nucleic acid substrates Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA Structure of DNA polymerase I Klenow fragment bound to duplex DNA Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I. Function and structure relationships in DNA polymerases Exonucleolytic proofreading during replication of repetitive DNA Deoxynucleoside triphosphate and pyrophosphate binding sites in the catalytically competent ternary complex for the polymerase reaction catalyzed by DNA polymerase I (Klenow fragment). A minor groove binding track in reverse transcriptase Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution Structural and mechanistic relationships between nucleic acid polymerases Polymerase structures and function: variations on a theme? A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides A thumb subdomain mutant of the large fragment of Escherichia coli DNA polymerase I with reduced DNA binding affinity, processivity, and frameshift fidelity. Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain Sequence-specific recognition of double helical nucleic acids by proteins Analyzing fidelity of DNA polymerases. Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta. Comparison of nucleotide interactions in water, proteins, and vacuum: model for DNA polymerase fidelity Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain. Purification of Escherichia coli DNA polymerase I and Klenow fragment. On molecular mechanisms of nucleic acid synthesis. Fidelity aspects: 2. Contribution of protein-nucleotide recognition
author name string	wds:Q77896965-08B9F22E-F903-4386-A5B2-4EC60098627A wds:Q77896965-0DCE1789-2101-41B2-8913-666B5BD6B5C1 wds:Q77896965-4E39E5F9-1830-4404-8B8E-3C50C00339C5 wds:Q77896965-858F5B7F-139C-4B21-BAC4-E5605BE732F3 wds:Q77896965-B05028AF-959C-455E-80F0-55B25B56D10C wds:Q77896965-E9B3BD68-3F71-4116-955B-BFBF9A3E191C wds:Q77896965-F7B52F6A-1B08-4594-A4A3-44B21AE20996
author name string	L Liu R M Turner C M Joyce M Astatke K Bebenek D T Minnick W P Osheroff
rdfs:label	Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (nl) Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment) (en) Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment) (sq)
skos:prefLabel	Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (nl) Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment) (en) Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment) (sq)
name	Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (nl) Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment) (en) Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment) (sq)
author	wds:Q77896965-5D4182E7-B2EE-4BA4-99D9-2E3B16CFB1C8
author	Thomas A Kunkel
title	wds:Q77896965-8B6F4DFE-5175-437A-96E7-BF8BC782432A
title	Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment) (en)
page(s)	wds:Q77896965-51D5121C-80A3-4ED8-945F-817BFED39145
page(s)	3067-3075
instance of	wds:Q77896965-BEBFD173-641B-43F8-9940-0CBE19A7680E
instance of	scholarly article
main subject	wds:Q77896965-1BF107F6-5B6B-4AD1-82F1-6AE4EF01023B
main subject	Escherichia coli
PubMed ID	wds:Q77896965-7D575243-216F-4212-8248-778A70232C90

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