About: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)

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About: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) Goto Sponge NotDistinct Permalink

An Entity of Type : wikibase:Item, within Data Space : wikidata.demo.openlinksw.com associated with source document(s)

class of ions

Attributes	Values
rdf:type	Item
description	class of ions (en)
rdfs:label	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) (en) 1-fosfatidil-1D-mio-inozitol 4,5-bisfosfat (5-) (sl)
skos:prefLabel	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) (en) 1-fosfatidil-1D-mio-inozitol 4,5-bisfosfat (5-) (sl)
name	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) (en) 1-fosfatidil-1D-mio-inozitol 4,5-bisfosfat (5-) (sl)
isomeric SMILES	wds:Q74701494-0090C600-15CA-449D-BDFA-400921FA0892
isomeric SMILES	O[C@@H]1[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](O)[C@@H]1OP([O-])(=O)OC[C@@H](COC([])=O)OC([])=O
instance of	wds:Q74701494-A0CD853A-D988-4389-81AE-DB9F3BCA89DE
part of	wds:Q74701494-151B3B58-12BE-4E02-A32F-66D4D764FDE6 wds:Q74701494-2DD7FBD2-5250-4E36-9215-52391C6E2A4B wds:Q74701494-6AF4DDDE-875E-4C78-ADDB-7F42839F36E9 wds:Q74701494-902EA1CA-15A8-4996-8BCA-C07115EB015C wds:Q74701494-9AE8BE44-0F8E-4B39-8EA2-0A85E2DBDDDA wds:Q74701494-A1FB7DBB-7EE9-4382-8189-0AEE0975473A wds:Q74701494-A6465A09-44DA-41FE-8F92-940BE3D8DA4C wds:Q74701494-AB554AE5-82A6-4611-8909-5CDE6E6DDBB1 wds:Q74701494-D392EF74-8502-4768-BAB2-A30CF0916BD7 wds:Q74701494-DF73AA9D-9343-4B16-BD4E-D811485BAA58 wds:Q74701494-EF069ADC-BF28-487F-A59C-677693513C03
instance of	structural class of chemical entities
part of	phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphatidylinositol phospholipase C activity phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process phosphatidylinositol-4,5-bisphosphate binding 1-phosphatidylinositol-4-phosphate 5-kinase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1-phosphatidylinositol-5-phosphate 4-kinase activity phosphatidylinositol-4,5-bisphosphate sensor activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
subclass of	wds:Q74701494-C7FE8F96-554C-46F2-8C38-9CE799042386 wds:Q74701494-D94389AC-D00B-4D83-A504-E9377AC8BB4F
subclass of	primary metabolite anionic phospholipid
ChEBI ID	wds:Q74701494-5609FE0B-CA83-42CF-88A3-E57E73BDF6AC
ChEBI ID	http://purl.obolibrary.org/obo/CHEBI_58456
ChEBI ID	58456
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q74701494
is has part(s) of	phosphatidylinositol-4,5-bisphosphate 3-kinase activity phosphatidylinositol phospholipase C activity phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process phosphatidylinositol-4,5-bisphosphate binding 1-phosphatidylinositol-4-phosphate 5-kinase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1-phosphatidylinositol-5-phosphate 4-kinase activity PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 PLC beta-mediated PIP2 hydrolysis Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 Translocation of PLC-gamma1 to PIP2 PLC-gamma1 hydrolyses PIP2 PTEN dephosphorylates PIP3 Hydrolysis of PIP2 by PLCG PI3K produces PIP3 and other phosphatidyl inositides Synthesis of PIP3 from PIP2 by PI3K Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers PLC gamma 2-mediated PIP2 hydrolysis PI(4,5)P2:AP-2:clathrin [plasma membrane] PI3K-containing complexes phosphorylate PIP2 to PIP3 PIP2 hydrolysis PI3K phosphorylates PIP2 to PIP3 EPOR-associated PI3K phosphorylates PIP2 to PIP3 CDC42:GTP:WASP/N-WASP [plasma membrane] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] Activation of WASP and N-WASP by CDC42 NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] Syndecan-4:PI(4,5)P2 [plasma membrane] Rap1-GTP:PIP2:RIAM [plasma membrane] Recruitment and activation of N-WASP by Cdc42 Syndecan-4 binds PI(4,5)P2 Translocation of RIAM to plasma membrane PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR AKT1 E17K mutant:PIP2 [plasma membrane] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 AKT1 E17K mutant binds PIP2 PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane phosphatidylinositol-4,5-bisphosphate sensor activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 PI3K synthesizes PIP3 downstream of ALK mutants EZR:PIP2 [plasma membrane] p-T567-EZR:PIP2 [plasma membrane] PIP2 hydrolysis Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. PIP2 binds inhibiting VAV PI3K alpha, beta, gamma convert PIP2 to PIP3 FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

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