About: High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and

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About: High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and Goto Sponge NotDistinct Permalink

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scientific article published on 01 January 2000

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rdf:type	Item
description	wetenschappelijk artikel (nl) wüsseschaftlicher Artikel, wo im Johr 2000 veröffentlicht worden isch (gsw) наукова стаття, опублікована в січні 2000 (uk) article scientifique publié en janvier 2000 (fr) im Januar 2000 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en xineru de 2000 (ast) artikull shkencor i botuar më 01 janar 2000 (sq) scientific article published on 01 January 2000 (en)
publication date	wds:Q74229453-31108B68-6086-42C9-B85A-5EC3DAEEF1E2
publication date	2000-01-01 00:00:00Z (xsd:dateTime)
cites work	wds:Q74229453-07F0EB94-3521-433E-81DD-E81DE3B030F9 wds:Q74229453-5E2D8724-9363-4E6D-9192-8AF2F7FD27F4 wds:Q74229453-5EF478F5-E9BF-4923-A1DE-CCDA1C3827C8 wds:Q74229453-74A6E32F-F53D-4945-B462-78267789A46F wds:Q74229453-791A3D26-0B38-4C24-9573-2A495E2CF779 wds:Q74229453-7D038F2A-B20D-4457-A81B-5EEC32D9BB94 wds:Q74229453-7E7A9C18-8178-4A78-BAE4-53B4DDC45A4F wds:Q74229453-92F9632E-A862-4489-A848-C910F917D94C wds:Q74229453-BC0C3297-A2DA-4C80-8B10-E407F9D6BAC0 wds:Q74229453-BCA83AC2-05D2-4A32-9E8B-2BBEFB62D9D5 wds:Q74229453-C2F3955C-5384-4589-BDFC-2AA4DC4BCD50 wds:Q74229453-C7564442-0F61-4EC1-9427-9DC571A1C896
cites work	P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes High-throughput bioanalytical LC/MS/MS determination of benzodiazepines in human urine: 1000 samples per 12 hours. High throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation. The use of high-flow high performance liquid chromatography coupled with positive and negative ion electrospray tandem mass spectrometry for quantitative bioanalysis via direct injection of the plasma/serum samples Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry. Use of "N-in-One" dosing to create an in vivo pharmacokinetics database for use in developing structure-pharmacokinetic relationships Rapid determination of oral pharmacokinetics and plasma free fraction using cocktail approaches: methods and application Determination of in vitro permeability of drug candidates through a caco-2 cell monolayer by liquid chromatography/tandem mass spectrometry High-throughput caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge extraction/tandem mass spectrometry
author name string	wds:Q74229453-4814CE0E-4FF0-4639-BC86-CB9F73AF80BF wds:Q74229453-71440701-C5E8-4740-9693-FEECB23380B1 wds:Q74229453-EAC29CD1-8AB8-4915-B47D-FCC29E156D3D wds:Q74229453-FCAE52B5-5B1E-4C66-BF9B-C86D9C1C3BAD
author name string	Teitelbaum P Bu HZ Knuth K Magis L
rdfs:label	High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and (en) High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and (nl)
skos:prefLabel	High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and (en) High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and (nl)
name	High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and (en) High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and (nl)
title	wds:Q74229453-B85CC9ED-12D7-4989-9440-9F24C89463A8
title	High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and their metabolites (en)
page(s)	wds:Q74229453-4226966F-8BEC-491E-B1C8-AD42A4B73F6D
page(s)	1619-1624
instance of	wds:Q74229453-1CBB1682-6DBC-4405-A0B5-79E8A59952CA
instance of	scholarly article
PubMed ID	wds:Q74229453-6FEABEC6-3033-4ED6-A498-916BF3602AD1
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10960916
PubMed ID	10960916
published in	wds:Q74229453-7835FBB1-6F5B-4A20-A33A-41508B3D13C3
published in	Rapid Communications in Mass Spectrometry
issue	wds:Q74229453-29ABDECE-4305-4FDB-97F0-8C0C02F7E4D5
volume	wds:Q74229453-2ECC10C9-3421-4B38-87F7-3F77D3BC6ECC
issue	17
volume	14
DOI	wds:Q74229453-C44474F2-78B1-4311-BB87-40CDDA00951E
DOI	http://dx.doi.org/10.1002/1097-0231(20000915)14:17%3C1619::AID-RCM71%3E3.0.CO;2-2
DOI	10.1002/1097-0231(20000915)14:17<1619::AID-RCM71>3.0.CO;2-2
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q74229453
is cites work of	High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. V. Validation of a direct injection/on-line guard cartridge extraction--tandem mass spectrometry method for CYP1A2 inhibition assessment Microsome biocolloids for rapid drug metabolism and inhibition assessment by LC-MS Screening of drug candidates for their drug--drug interaction potential High-throughput high-performance liquid chromatography/mass spectrometry for modern drug discovery High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy: III. Validation of a direct injection/on-line guard cartridge extraction-tandem mass spectrometry method for CYP2C19 inhibition evaluation Defining the role of pharmacology in the emerging world of translational research. Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry Synchronized dual-polarity electrospray ionization mass spectrometry Application of semi-automated metabolite identification software in the drug discovery process for rapid identification of metabolites and the cytochrome P450 enzymes responsible for their formation Development and validation of an in vitro, seven-in-one human cytochrome P450 assay for evaluation of both direct and time-dependent inhibition.
is cites work of	wds:Q43620137-CF1ABFD9-7FEC-41E1-96E7-7179DEFE25F4 wds:Q74210449-4FC7F296-94EE-4C4F-8ABC-CEE546D649E7 wds:Q32079778-9796EDBB-102C-4175-B69F-A0E0B03E8087 wds:Q34318051-E3AF9F80-A722-492E-8D2B-69ECBD98AA3F wds:Q53187390-5DD934F8-5BD2-4318-B365-D4F1B846BDCA wds:Q36323058-98A480BE-47D4-4BEC-9132-E1C456F2CF4E wds:Q44194942-1B650510-ED72-4CD3-B90A-41C07EC3C130 wds:Q53119815-4E5EA4BE-AF3D-4267-AF52-CA762B517EF8 wds:Q34134991-DE801B01-488E-4F01-8ED9-A248DD987527 wds:Q84582504-721976EA-F21B-4AEC-8EFC-1AA7170DC5B6

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