About: Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

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About: Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors Goto Sponge NotDistinct Permalink

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scientific article published on 01 November 2000

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в листопаді 2000 (uk) im November 2000 veröffentlichter wissenschaftlicher Artikel (de) article scientifique publié en novembre 2000 (fr) artículu científicu espublizáu en payares de 2000 (ast) scientific article published on 01 November 2000 (en)
publication date	wds:Q74071559-86C17FAC-9E7D-4CAD-9D37-D15DD9CB0984
publication date	2000-11-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q74071559-B315F80A-6AB3-4BDB-8547-F60C5787C88D
language of work or name	English
cites work	wds:Q74071559-A5D35CFC-A0BA-41F7-A991-000B71A8D6E6 wds:Q74071559-AF1C9CE2-33E1-4455-A47A-729CDA2432C7
cites work	Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity Purification and cloning of amyloid precursor protein beta-secretase from human brain
author name string	wds:Q74071559-15B0E0A0-7327-4BD6-8750-DBC48BC47DD5 wds:Q74071559-2F3A060F-B36C-4375-9623-7DDD5E26EC96 wds:Q74071559-305FF649-C750-4DAC-99E0-FD1F107CD003 wds:Q74071559-45C1BB43-0151-4E51-8A0B-3595AC9E9271 wds:Q74071559-67274ED9-FAF9-4BA2-B6B9-620C243C8530 wds:Q74071559-786066E9-688E-469C-B200-64077B66D401 wds:Q74071559-794B3559-27E2-413E-8265-13915095E5F0 wds:Q74071559-8284ED54-174D-4BDB-82AF-CE31E6669776 wds:Q74071559-8A2E2824-3955-4DDE-BF26-42A38A477D2D wds:Q74071559-94BB413E-76FA-4B8D-9320-52E56AA83BDA wds:Q74071559-A81F1930-8CD6-4BB7-A0B5-D1C12BCAAAF4 wds:Q74071559-B5E457E6-1C84-47E7-A89B-9F2B92BADBC4 wds:Q74071559-B8B7575D-8647-414D-84BB-33B96E06936A wds:Q74071559-BAD37D14-EB42-454D-B12D-327830BEE8D1 wds:Q74071559-CD976653-1B37-477B-9B0D-B4C23FF97DBF wds:Q74071559-D0B2C686-4693-4EBB-BA4C-F9B59083D4EF wds:Q74071559-D5B3E417-40E2-40ED-8C9A-C422B5D522AC wds:Q74071559-ECFD719F-F274-4C49-A1D9-F971745FEDA6 wds:Q74071559-F0F0DF9C-7A06-40F1-83A0-C03DB1F899AC wds:Q74071559-F6A93393-055F-4230-A040-31CE3CB3102B
author name string	Wang Q Yang F Copeland RA Cordell B Higaki JN Olson RE Robertson DW Bradley JD Zaczek R Prakash SR Seiffert D Roach AH Hartig PR Thompson LA Arneric SP Spitz SM Rominger DH Combs AP Meredith JE Jr Rominger CM
rdfs:label	Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors (en) Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors (nl)
skos:prefLabel	Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors (en) Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors (nl)
name	Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors (en) Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors (nl)
author	wds:Q74071559-435968C7-A279-4E2B-A78B-AB4B3C93B776
author	Andrew M Stern
title	wds:Q74071559-5B05E08A-9893-461B-BE3C-340011083C6F
title	Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors (en)
page(s)	wds:Q74071559-13BC0351-E4F5-4E14-9624-3B4AEDD43C2B
page(s)	34086-34091
instance of	wds:Q74071559-A2CCB987-F90D-4FB7-B1BB-B663D412300A
instance of	scholarly article
PubMed ID	wds:Q74071559-5EECAE1C-261F-408C-A1D1-F49359643134
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10915801
PubMed ID	10915801
published in	wds:Q74071559-9861D840-8BC9-43A1-A796-81F893EED837
published in	Journal of Biological Chemistry
issue	wds:Q74071559-86E581B2-006E-4CA2-AEF3-EB36EADBCA60
volume	wds:Q74071559-B7E7F3BD-7216-42F0-A148-EC901F6509FE
issue	44
volume	275
DOI	wds:Q74071559-3EA20FB9-00CF-48AE-82FC-11E956B32CAA
DOI	http://dx.doi.org/10.1074/JBC.M005430200
DOI	10.1074/JBC.M005430200
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q74071559
is cites work of	The secretases of Alzheimer's disease Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain. Presenilin-dependent gamma-secretase activity modulates thymocyte development Amyloid fibril proteins Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4 Role of the ErbB-4 carboxyl terminus in gamma-secretase cleavage Direct inhibition of the NOTCH transcription factor complex Treatment strategies targeting amyloid β-protein Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia Presenilin attenuates receptor-mediated signaling and synaptic function. Amyloid metabolism and secretases in Alzheimer's disease Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch- and hedgehog-dependent tumor-initiating cells. Notch receptor cleavage depends on but is not directly executed by presenilins Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling Alzheimer disease therapy: can the amyloid cascade be halted?

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