About: Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs

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About: Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs Goto Sponge NotDistinct Permalink

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scientific article published on 01 June 2000

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в червні 2000 (uk) im Juni 2000 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en xunu de 2000 (ast) scientific article published on 01 June 2000 (en)
publication date	wds:Q73755207-D034052C-4C6B-4423-B94E-E8BEFF062B8B
publication date	2000-06-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73755207-1A18B91C-D526-4141-8BDA-AAB6B1A2FC94
language of work or name	English
cites work	wds:Q73755207-0529CFD8-5746-40D2-B482-1F47AEC6FBDF wds:Q73755207-0EF69B97-9092-4262-B912-DDB5324530A4 wds:Q73755207-13E823F6-3D96-41B5-ACDF-798A8CC1C4C0 wds:Q73755207-18ADEC13-C4AC-46BB-9D21-60BA9B0D2345 wds:Q73755207-18FF5440-CFDC-4081-A2FA-599497BEDA39 wds:Q73755207-26ABA77A-C9C7-43AF-BA4D-9B009823F1C0 wds:Q73755207-26F5190D-C912-4B6B-A228-294F30568CB0 wds:Q73755207-2B434996-737C-48B2-A0D1-961A6C0F8C1B wds:Q73755207-40A1C083-50CF-4628-AF32-87B0F1BAC7FE wds:Q73755207-423F271F-9844-45FB-8B52-EBA952380596 wds:Q73755207-42FAD404-2AE4-42B5-9629-C168478F635D wds:Q73755207-6E535BF8-8AC6-4988-A7D4-F1F6C28C2776 wds:Q73755207-7A808CF7-8613-4EF6-B027-4A9DEE90065B wds:Q73755207-7E64813E-E94E-4479-A6B8-7FFDB9B45459 wds:Q73755207-802EB5C3-BA77-45CD-ACE0-A65010C706DA wds:Q73755207-8C871430-1DA3-4692-8BFA-19C5A35B367F wds:Q73755207-9A4ED452-4E75-4D3C-A054-16E69DEE2390 wds:Q73755207-9CAD481F-D1C5-48E3-B7AA-E04308DBB5D7 wds:Q73755207-AB741CF3-131D-4E79-9A2D-BD0F44940E00 wds:Q73755207-B4ECD445-9840-4F36-8FB8-0087717F5F50 wds:Q73755207-B690D35E-9A27-437D-AD13-98390DC7002B wds:Q73755207-C53D9EBE-765B-4DB7-9421-8E16ECE33441 wds:Q73755207-D066A01E-1E59-435F-8065-E369A282CF8B wds:Q73755207-D498DC4B-8CC6-43BC-9D58-094072CBAF98 wds:Q73755207-F838F7CD-0A42-4031-921A-75D0397ACEDA
cites work	Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II. Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals. Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy") 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy"): pharmacology and toxicology in animals and humans Centrally active N-substituted analogs of 3,4-methylenedioxyphenylisopropylamine (3,4-methylenedioxyamphetamine) Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens. Identification of a new therapeutic class: entactogens Psychological effects of MDE in normal subjects. Are entactogens a new class of psychoactive agents? Memory impairment in abstinent MDMA ("Ecstasy") users. Recreational use of "ecstasy" (MDMA) is associated with elevated impulsivity. Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture Fatal interaction between ritonavir and MDMA Disposition of methylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion. Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings. Quantitation of N-ethyl-3,4-methylenedioxyamphetamine and its major metabolites in human plasma by high-performance liquid chromatography and fluorescence detection Pathology of deaths associated with "ecstasy" and "eve" misuse Ion trap tandem mass spectrometric evidence for the metabolism of 3,4-(methylenedioxy)methamphetamine to the potent neurotoxins 2,4,5-trihydroxymethamphetamine and 2,4,5-trihydroxyamphetamine In vivo and in vitro metabolism of 3,4-(methylenedioxy)methamphetamine in the rat: identification of metabolites using an ion trap detector Functional properties of CYP2D6 1 (wild-type) and CYP2D6 7 (His324Pro) expressed by recombinant baculovirus in insect cells Adverse reactions with 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy'). The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6) Differences in induction of hepatic cytochrome P450 isozymes by mice in eight methylenedioxyphenyl compounds Fatal MDMA intoxication Human cytochromes P450 expressed in Escherichia coli: production of specific antibodies. Adam and Eve make love. Analysis of the enantiomers of 3,4-methylenedioxy-N-ethylamphetamine (MDE, "Eve") and its metabolite 3,4-methylenedioxyamphetamine (MDA) in rat brain
author name string	wds:Q73755207-1CB5C27D-5C0E-41D2-8CD4-9267E7FC616D wds:Q73755207-47192A84-117A-4915-A569-C1F0B57E8950 wds:Q73755207-8E5244C9-E3D9-41E0-A4A7-14321A423CD1 wds:Q73755207-F2C12CAD-AD1A-4C62-8491-65ECDA9CC0D0
author name string	M Schwab U M Zanger K Kovar K Kreth
rdfs:label	Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs (en) Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs (nl)
skos:prefLabel	Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs (en) Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs (nl)
name	Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs (en) Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs (nl)
title	wds:Q73755207-A0694E4B-5E1E-4530-8C72-22049BD3A977
title	Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs (en)
page(s)	wds:Q73755207-96EAE68B-7F10-4637-B91B-D929F45BF4F7
page(s)	1563-1571
instance of	wds:Q73755207-24752D37-CBB2-4071-8AB1-66DC04E21BE6
instance of	scholarly article
PubMed ID	wds:Q73755207-04E8AED8-6748-45A1-84DA-957BEDA0551F
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10799653
PubMed ID	10799653
published in	wds:Q73755207-B8B6057A-0C51-4FF1-9F8B-02F4EED55260
published in	Biochemical Pharmacology
issue	wds:Q73755207-D667FA92-ACA0-4540-BF18-79C5AE226588
volume	wds:Q73755207-5793370A-77B7-4D7A-A7CE-209CAA9258AE
issue	12
volume	59
DOI	wds:Q73755207-369202D5-0F8F-4D7A-A96C-FFB233B2AA30
DOI	http://dx.doi.org/10.1016/S0006-2952(00)00284-7
DOI	10.1016/S0006-2952(00)00284-7
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q73755207
is cites work of	MDMA, methamphetamine, and CYP2D6 pharmacogenetics: what is clinically relevant? Preventing Problems in Ecstasy Users: Reduce Use to Reduce Harm Molecular characterization of CYP2B6 substrates The Neuropsychopharmacology and Toxicology of 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA). P-glycoprotein modulation by the designer drugs methylenedioxymethamphetamine, methylenedioxyethylamphetamine and paramethoxyamphetamine Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro. Drug-metabolizing cytochrome P450s in the brain.

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