About: CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells

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About: CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells Goto Sponge NotDistinct Permalink

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scientific article published on 01 September 1997

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована у вересні 1997 (uk) im September 1997 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en setiembre de 1997 (ast) scientific article published on 01 September 1997 (en)
publication date	wds:Q73743373-24221759-9793-4575-96A4-057BE745B527
publication date	1997-09-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73743373-92923D5B-529A-4FD2-82D2-A4719D800BF6
language of work or name	English
exact match	wds:Q73743373-2B0889DC-0B9B-478F-8C0D-4AE85B043989
exact match	https://scigraph.springernature.com/pub.10.1038/sj.onc.1201305
author name string	wds:Q73743373-05907180-BC90-48B5-B571-9E9BD11EEBD3 wds:Q73743373-8D1C8329-5C67-4807-BC5E-27DFBA7C5131 wds:Q73743373-92EB395A-FF4E-4823-94D4-67A01FAD310B wds:Q73743373-A57481FC-D7DC-407B-AFE5-1F830D7A4472 wds:Q73743373-A59F445D-09CD-43DC-9BE8-583C8223341F wds:Q73743373-BC509277-652D-4A30-8D34-DF301D7BFDEF wds:Q73743373-FB79257D-6FAA-4DFA-803F-31897561F1F5
author name string	Cao W Liu PP Friedman AD Kelley CA Claxton DF Speck NA Britos-Bray M
rdfs:label	CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells (en) CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells (nl)
skos:prefLabel	CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells (en) CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells (nl)
name	CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells (en) CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells (nl)
title	wds:Q73743373-A7986742-DDB4-4348-A032-7B49923EE052
title	CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells (en)
page(s)	wds:Q73743373-24515654-A429-421F-A663-A6D673B757BC
page(s)	1315-1327
instance of	wds:Q73743373-1A950CB7-F2E7-48E6-9B43-166CCAFFCB75
instance of	scholarly article
PubMed ID	wds:Q73743373-307D122E-AC26-4DEB-8E6E-3E904CD5D060
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9315100
PubMed ID	9315100
published in	wds:Q73743373-92B4BDFA-F357-4389-BE15-8AAAEF1CDBFA
published in	Oncogene
issue	wds:Q73743373-0DE56D20-5295-4ECE-B274-D95C9EF12EB6
volume	wds:Q73743373-46D05BD7-48BA-4613-87D3-8A6A35052FF1
issue	11
volume	15
DOI	wds:Q73743373-55155A30-B43C-4DCE-8FC8-E4A42E7B25A5
DOI	http://dx.doi.org/10.1038/SJ.ONC.1201305
DOI	10.1038/SJ.ONC.1201305
Dimensions Publication ID	wds:Q73743373-C6F7AB68-4B54-468B-86CF-17C9559A8E2B
Dimensions Publication ID	1032663176
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q73743373
is cites work of	The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain Transcriptional regulation of granulocyte and monocyte development AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression Common themes in the pathogenesis of acute myeloid leukemia The Runx genes: lineage-specific oncogenes and tumor suppressors The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia AML1 stimulates G1 to S progression via its transactivation domain Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3. ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor The PEBP2beta/CBF beta-SMMHC chimeric protein is localized both in the cell membrane and nuclear subfractions of leukemic cells carrying chromosomal inversion 16. The Runx genes as dominant oncogenes Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor alpha (CBFalpha) subunit by the leukemia-related PEBP2/CBFbeta-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation Multimerization via its myosin domain facilitates nuclear localization and inhibition of core binding factor (CBF) activities by the CBFbeta-smooth muscle myosin heavy chain myeloid leukemia oncoprotein Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31. Integrative analysis of RUNX1 downstream pathways and target genes Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11. Cell cycle and developmental control of hematopoiesis by Runx1. Runx1 loss minimally impacts long-term hematopoietic stem cells Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells Inducible nitric oxide synthase expression inhibition by adenovirus E1A. Transcriptional regulation of myelopoiesis Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation CBFbeta-SMMHC slows proliferation of primary murine and human myeloid progenitors Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis C/EBP alpha:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBP alpha homodimers or AP-1 Cell cycle inhibition mediated by the outer surface of the C/EBPα basic region is required but not sufficient for granulopoiesis TGF-β superfamily gene expression and induction of the Runx1 transcription factor in adult neurogenic regions after brain injury. Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF - a model for overcoming inhibition of proliferation by CBF oncoproteins Transcription factor fusions in acute leukemia: variations on a theme. Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia Identification of a region on the outer surface of the CBFbeta-SMMHC myeloid oncoprotein assembly competence domain critical for multimerization Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors Granulopoiesis
is cites work of	wds:Q35779737-C61B16C3-7479-46D5-B2CC-65AB0606E203 wds:Q36543603-0EADC82D-9957-4C8B-8026-CEBCF2589A84 wds:Q38296255-2D9BF243-164E-4BE8-983C-E1EC8970D2E5 wds:Q39675523-519CFED2-2456-4CBC-A8BF-7FF33F74AD02 wds:Q56355644-DA6340A0-9030-461E-B6BF-8A6B8AE40E3B wds:Q24554277-3C935F4D-C4B0-4DEF-9BAB-02BA5CB5E87D wds:Q34658545-6B507A64-3451-4D4C-A196-E87A39D75783

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