About: Genomic instability and apoptosis are frequent in p53 deficient young mice

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scientific article published on 01 September 1997

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована у вересні 1997 (uk) im September 1997 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en setiembre de 1997 (ast) scientific article published on 01 September 1997 (en)
publication date	wds:Q73743370-F48C4F17-82F7-4593-BAFE-38A77A0A3F5A
publication date	1997-09-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73743370-845D5610-C228-4104-9346-81C8CC142C5E
language of work or name	English
exact match	wds:Q73743370-24DB649F-F477-4864-A85C-38C27DA9BDF2
exact match	https://scigraph.springernature.com/pub.10.1038/sj.onc.1201482
author name string	wds:Q73743370-8C24C984-9413-4234-8BDF-618317F86C44 wds:Q73743370-AA66E409-DD4D-4863-AF5B-A9578CF1B1FA wds:Q73743370-BA370CC0-B763-4E02-93BD-01404BBE0D1A wds:Q73743370-FBFC4209-BBC7-45DD-B815-86E64E30C877
author name string	Fukasawa K Vande Woude GF Wiener F Mai S
rdfs:label	Genomic instability and apoptosis are frequent in p53 deficient young mice (en) Genomic instability and apoptosis are frequent in p53 deficient young mice (nl)
skos:prefLabel	Genomic instability and apoptosis are frequent in p53 deficient young mice (en) Genomic instability and apoptosis are frequent in p53 deficient young mice (nl)
name	Genomic instability and apoptosis are frequent in p53 deficient young mice (en) Genomic instability and apoptosis are frequent in p53 deficient young mice (nl)
title	wds:Q73743370-AA0E0866-99ED-4862-B221-42EA9919C4D1
title	Genomic instability and apoptosis are frequent in p53 deficient young mice (en)
page(s)	wds:Q73743370-428674A9-3C61-49B4-8E5C-A751A3701FA1
page(s)	1295-1302
instance of	wds:Q73743370-3EBEB482-CDB3-46A7-85C7-50DD5E2613B8
instance of	scholarly article
main subject	wds:Q73743370-8FFCB239-730A-4078-8464-BADBDEA02809
main subject	apoptotic process
PubMed ID	wds:Q73743370-F51732B6-5C8B-4565-AA08-B9AB8BE43727
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9315097
PubMed ID	9315097
published in	wds:Q73743370-0E56957F-313E-4243-B544-5D30147E7F43
published in	Oncogene
issue	wds:Q73743370-B71D6807-D386-4B83-A1CF-F1B2228EEFAE
volume	wds:Q73743370-67886AB2-6BF9-4C85-879D-1B9643840EDA
issue	11
volume	15
DOI	wds:Q73743370-81074B41-1A58-43BD-A540-14A52E1A6964
DOI	http://dx.doi.org/10.1038/SJ.ONC.1201482
DOI	10.1038/SJ.ONC.1201482
Dimensions Publication ID	wds:Q73743370-DD756080-9C0C-440E-B901-4686F1E786D2
Dimensions Publication ID	1026441349
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q73743370
is cites work of	A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability. The impact of p53 loss on murine plasmacytoma development Telomeric aggregates and end-to-end chromosomal fusions require myc box II. Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression The antioxidant function of the p53 tumor suppressor p19ARF directly and differentially controls the functions of c-Myc independently of p53. Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. The role of the centrosome in the development of malignant tumors Loss of p53 and centrosome hyperamplification. APC, signal transduction and genetic instability in colorectal cancer The centrosome in higher organisms: structure, composition, and duplication Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest. Effect of p53 on centrosome amplification in prostate cancer cells Mutations in exons 5-8 of the p53 gene, independent of their type and location, are associated with increased apoptosis and mitosis in invasive breast carcinoma Prospective identification of tumorigenic breast cancer cells The APC gene in colorectal cancer p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the core Chromosomes and cancer cells. Diverse system stresses: common mechanisms of chromosome fragmentation. c-MYC-induced genomic instability. The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53. Temporal dissection of p53 function in vitro and in vivo Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Cross-species genomic and epigenomic landscape of retinoblastoma Mechanisms of switching on p53: a role for covalent modification? Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes Chromosomal instability in osteosarcoma and its association with centrosome abnormalities. Selective suppression of lymphomas by functional loss of Hsf1 in a p53-deficient mouse model for spontaneous tumors Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells Selective inactivation of p53 facilitates mouse epithelial tumor progression without chromosomal instability Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: evidence that GAPDH is upregulated by p53 Oncogenes and tumour suppressors take on centrosomes p53: guardian of ploidy Phosphorylation of murine p53, but not human p53, by MAP kinase in vitro and in cultured cells highlights species-dependent variation in post-translational modification Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus c-Myc-dependent formation of Robertsonian translocation chromosomes in mouse cells Phase I study of MLN8237--investigational Aurora A kinase inhibitor--in relapsed/refractory multiple myeloma, non-Hodgkin lymphoma and chronic lymphocytic leukemia Isolation and characterization of the TERE1 gene, a gene down-regulated in transitional cell carcinoma of the bladder Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage Exploring Different Strategies for Efficient Delivery of Colorectal Cancer Therapy P53, cyclin-dependent kinase and abnormal amplification of centrosomes P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells c-Myc-associated genomic instability of the dihydrofolate reductase locus in vivo p53 Alteration and chromosomal instability in prostatic high-grade intraepithelial neoplasia and concurrent carcinoma: analysis by immunohistochemistry, interphase in situ hybridization, and sequencing of laser-captured microdissected specimens. Increased Expression of Bcl-xL and c-Myc Is Associated with Transformation by Abelson Murine Leukemia Virus Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells. Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

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