About: Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha(2)-macroglobulin receptor

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About: Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha(2)-macroglobulin receptor Goto Sponge NotDistinct Permalink

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scientific article published on 01 March 2000

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) wüsseschaftlicher Artikel, wo im März 2000 veröffentlicht worden isch (gsw) im März 2000 veröffentlichter wissenschaftlicher Artikel (de) наукова стаття, опублікована в березні 2000 (uk) artículu científicu espublizáu en marzu de 2000 (ast) scientific article published on 01 March 2000 (en)
publication date	wds:Q73538310-85B72210-8CA6-490A-A567-F0E53F418EF8
publication date	2000-03-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73538310-00F4B618-F2BE-4E65-9A6E-4AF11583E316
language of work or name	English
cites work	wds:Q73538310-059129FF-FC13-46F2-B662-1E75F9840449 wds:Q73538310-1D50F2FD-3525-4ABD-B7A5-665C3418A84D wds:Q73538310-234FD625-5C3F-4B1F-BAA1-396BDFD8C982 wds:Q73538310-301B42E2-3EC6-442D-AD7D-F2F69BB33820 wds:Q73538310-3406B4D1-B9D9-4D4C-BEC5-B6DC2B32E967 wds:Q73538310-4F83D729-2B8F-4B26-9055-200C32D3EBDF wds:Q73538310-521981C0-7284-438F-9B5D-A907E14FA877 wds:Q73538310-5B696956-C34B-4AD3-9C04-E6D1C87F4E4E wds:Q73538310-6726BED7-33CB-4DED-9B43-B1A263DA7C84 wds:Q73538310-6C010D46-D71E-465A-B992-4EAD48E50B74 wds:Q73538310-6D8BB576-8BB9-40A9-AAE8-F3F7F016BA3E wds:Q73538310-7A255C40-EB38-4FC3-9620-1A934045877F wds:Q73538310-7B96BF87-E6E4-4A84-AE12-2F8EEFD64CB1 wds:Q73538310-7FE8075B-F3FF-4D42-9B22-31377B66AA24 wds:Q73538310-8C79DD36-A37F-4486-86B0-9D04ADC2E992 wds:Q73538310-9CEC2E20-C0D6-458C-9C62-C6D76B0ABE28 wds:Q73538310-A0115B1A-F7BC-4852-B130-A4F855E8DF72 wds:Q73538310-A0E778F2-2D9E-4698-9E18-DB6B7F4E00C7 wds:Q73538310-A240CEF0-C220-4513-B734-64A847E1CEFD wds:Q73538310-A245F012-4638-4A57-8AB6-80CC88F78364 wds:Q73538310-A72185D3-E1F6-49FF-84DF-A49464CDCF28 wds:Q73538310-A9A7B9FE-67BA-4A2C-81EF-2AB0CE8D2C61 wds:Q73538310-AA53B2D4-CCC8-4B8F-8CEE-86BF8BA89227 wds:Q73538310-AD456026-D360-4B91-BF97-5B9ABBF7AC57 wds:Q73538310-BA691979-DCDC-4421-A001-45AA3C78ACFF wds:Q73538310-C9FDA4E5-05D6-479D-9A8D-35258171A281 wds:Q73538310-CA214714-C9C4-4420-9E5C-52B3E183419B wds:Q73538310-CDFEDBA6-E500-4548-A8C2-57CA39ACA0D9 wds:Q73538310-D9369D34-8378-40F0-9BD4-22311A075C38 wds:Q73538310-DCEF6BB7-57E6-43D4-ADBC-BE2FBE14066D wds:Q73538310-E78181B2-A62E-4F3F-8895-D929E02EDD2F wds:Q73538310-E923DD32-8D7E-4AB2-9009-711CEDB4270D wds:Q73538310-F0483B94-FF00-47E8-905E-1D591C0A92AE wds:Q73538310-F37D2C5D-3A4A-47D9-8AE8-27122EB0DA22 wds:Q73538310-F3C6E14D-1F84-4C5B-A055-5B27C69B8E85 wds:Q73538310-FBF90414-6B0C-4E73-8E41-C7321C43301A
cites work	Photoaffinity labeling of the human receptor for urokinase-type plasminogen activator using a decapeptide antagonist. Evidence for a composite ligand-binding site and a short interdomain separation Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1 Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction Circularly permuted interleukin 4 retains proliferative and binding activity. Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product The N-terminal region of the 37-kDa translocated fragment of Pseudomonas exotoxin A aborts translocation by promoting its own export after microsomal membrane insertion Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity Targeting plant toxins to the urokinase and alpha 2-macroglobulin receptors An early step in Pseudomonas exotoxin action is removal of the terminal lysine residue, which allows binding to the KDEL receptor Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli. One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell Domain II of Pseudomonas exotoxin A arrests the transfer of translocating nascent chains into mammalian microsomes Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds. The Major N-Linked Carbohydrate Chains from Human Urokinase. The Occurrence of 4-O-sulfated, (alpha2-6)-sialylated or (alpha1-3)-fucosylated N-acetylgalactosamine(beta1-4)-N-acetylglucosamine Elements Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated by cynomolgus monkeys Expression of the receptor for urokinase-type plasminogen activator in normal and neoplastic blood cells and hematopoietic tissue A urokinase receptor mRNA binding protein-mRNA interaction regulates receptor expression and function in human pleural mesothelioma cells. Urokinase and the urokinase receptor: association with in vitro invasiveness of human bladder cancer cell lines Cancer cells overexpress mRNA of urokinase-type plasminogen activator, its receptor and inhibitors in human non-small-cell lung cancer tissue: analysis by Northern blotting and in situ hybridization Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv). Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution High-affinity urokinase receptor antagonists identified with bacteriophage peptide display PMA-induced down-regulation of the receptor for alpha 2-macroglobulin in human U937 cells. A form of anti-Tac(Fv) which is both single-chain and disulfide stabilized: comparison with its single-chain and disulfide-stabilized homologs Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin Carbohydrate composition and presence of a fucose-protein linkage in recombinant human pro-urokinase Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin Cytotoxicity of KDEL-terminated ricin toxins correlates with distribution of the KDEL receptor in the Golgi Expression and functional role of urokinase-type plasminogen activator receptor in normal and acute leukaemic cells Prolonged half-life in the circulation of a chemical conjugate between a pro-urokinase derivative and human serum albumin The Cloning, Isolation and Characterization of a Biologically Active Human Enzyme, Urokinase, in E. Coli
author name string	wds:Q73538310-AE5DFC67-C6A1-40A3-BBA6-7BD941FB21F9 wds:Q73538310-BCAA9107-916D-420E-9FB2-A6B8B93CA6A8
author name string	R J Kreitman V Rajagopal
rdfs:label	Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha (nl) Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha(2)-macroglobulin receptor (en)
skos:prefLabel	Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha (nl) Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha(2)-macroglobulin receptor (en)
name	Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha (nl) Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha(2)-macroglobulin receptor (en)
title	wds:Q73538310-258DD127-A2EF-41A2-9583-28D9EEECFC34
title	Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha(2)-macroglobulin receptor (en)
page(s)	wds:Q73538310-F6C2DB6C-9DFC-45EC-B00E-E48CD5BCC3AE
page(s)	7566-7573
instance of	wds:Q73538310-3F6C5329-C13C-45CB-A18C-8B4574D9DE32
instance of	scholarly article
PubMed ID	wds:Q73538310-767E7609-A25D-422F-A080-550A590A9ADE

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