About: Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB

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About: Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB Goto Sponge NotDistinct Permalink

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scientific article published on 01 June 1997

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в червні 1997 (uk) article scientifique publié en 1997 (fr) im Juni 1997 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en xunu de 1997 (ast) scientific article published on 01 June 1997 (en)
publication date	wds:Q73427445-221C6AC0-415D-4A36-8907-54CF0C6FF470
publication date	1997-06-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73427445-BCAED871-A1DD-454F-BE80-499185B056FD
language of work or name	English
author name string	wds:Q73427445-36BB5F3A-3840-430D-89E0-64FC069A3277 wds:Q73427445-85FBD7C4-24F7-4491-BA35-F07ADD9EC25D wds:Q73427445-89C5FB59-2E9C-47B1-A2E2-00716A375CFE wds:Q73427445-B9D89ED7-CB6E-4918-999B-7AFAD7207CE5
author name string	G C Prendergast P J Casey P F Lebowitz J A Thissen
rdfs:label	Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB (en) Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB (nl)
skos:prefLabel	Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB (en) Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB (nl)
name	Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB (en) Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB (nl)
title	wds:Q73427445-56435CA0-E669-4C8C-9653-1D23FE4A8680
title	Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB (en)
page(s)	wds:Q73427445-6B71F9C7-4A68-4023-97E6-50D302905609
page(s)	15591-15594
instance of	wds:Q73427445-0FDDB1F3-DA8A-4DC4-9383-0C15022C1F69
instance of	scholarly article
PubMed ID	wds:Q73427445-7E20470C-F07E-44CD-A4B4-4314ABDE7062
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9188444
PubMed ID	9188444
published in	wds:Q73427445-17AA401D-794D-4589-A1FD-80B5E3907B6C
published in	Journal of Biological Chemistry
issue	wds:Q73427445-9729E54A-4837-4CF8-BD1F-9D08AA0764A1
volume	wds:Q73427445-7C829DFF-555D-4F71-A029-13083DA9C507
issue	25
volume	272
number of pages	wds:Q73427445-B1B754A6-7DF6-4030-8C01-E260A4F9FDBB
number of pages	4 (xsd:decimal)
DOI	wds:Q73427445-85437F2F-48D4-4BDA-BA45-6B693F039874
DOI	http://dx.doi.org/10.1074/JBC.272.25.15591
DOI	10.1074/JBC.272.25.15591
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q73427445
is cites work of	RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development Farnesyl protein transferase inhibitors as targeted therapies for hematologic malignancies Targeting protein prenylation for cancer therapy Rho-regulatory proteins in breast cancer cell motility and invasion RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1. Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates Breast cancer stem cells survive periods of farnesyl-transferase inhibitor-induced dormancy by undergoing autophagy A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage Actin' up: RhoB in cancer and apoptosis Ras activation in human breast cancer Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells Farnesyltransferase inhibitors induce dramatic morphological changes of KNRK cells that are blocked by microtubule interfering agents p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA. A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells. Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets RhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: evidenced in vivo by an anti-farnesyl cysteine antibody Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway Inhibition of RAS-targeted prenylation: protein farnesyl transferase inhibitors revisited Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway A phase I multicenter study of continuous oral administration of lonafarnib (SCH 66336) and intravenous gemcitabine in patients with advanced cancer Opinion: Searching for the elusive targets of farnesyltransferase inhibitors Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis The Medical Management of Pancreatic Cancer: A Review Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability Functional requirement of plant farnesyltransferase during development in Arabidopsis Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases Efficient prenylation by a plant geranylgeranyltransferase-I requires a functional CaaL box motif and a proximal polybasic domain. Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects. Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies Farnesyltransferase inhibitors: targeting the molecular basis of cancer Ras oncogenes: split personalities Therapeutic intervention and signaling Protein farnesylation in plants: a greasy tale RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification. Geranylgeranyltransferase I of Candida albicans: null mutants or enzyme inhibitors produce unexpected phenotypes Investigation of S-farnesyl transferase substrate specificity with combinatorial tetrapeptide libraries. Ras acylation, compartmentalization and signaling nanoclusters (Review). Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast Farnesyltransferase inhibitors versus Ras inhibitors. The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of NIH-3T3 cells Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia Protein prenyltransferases Palmitoylation of oncogenic NRAS is essential for leukemogenesis Induction of apoptosis in neurofibromatosis type 1 malignant peripheral nerve sheath tumor cell lines by a combination of novel farnesyl transferase inhibitors and lovastatin Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II Geranylgeranylated RhoB is sufficient to mediate tissue-specific suppression of Akt kinase activity by farnesyltransferase inhibitors RhoB controls the 24 kDa FGF-2-induced radioresistance in HeLa cells by preventing post-mitotic cell death

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