About: Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships

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About: Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships Goto Sponge NotDistinct Permalink

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scientific article published on 01 December 1999

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в грудні 1999 (uk) article scientifique publié en 1999 (fr) im Dezember 1999 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'avientu de 1999 (ast) scientific article published on 01 December 1999 (en)
publication date	wds:Q73364992-DE1D5ED2-0EA7-45E3-8236-EDE2EECAA0A7
publication date	1999-12-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73364992-7116E9D0-EBD2-4A98-98B1-235738A2A139
language of work or name	English
author name string	wds:Q73364992-500AADEB-93A8-43DB-86CD-6BDEF801388A wds:Q73364992-74B1A07D-8972-46CB-AD35-BA1B6669264B wds:Q73364992-AF3EBF39-C687-421E-9F0F-132C0BC57327 wds:Q73364992-F1EAB824-AC4E-4832-B345-465590097137
author name string	R L Krauth-Siegel S Bonse J Barbe C Santelli-Rouvier
rdfs:label	Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships (en) Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships (nl)
skos:prefLabel	Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships (en) Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships (nl)
name	Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships (en) Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships (nl)
title	wds:Q73364992-FEE4DB27-3FAB-412D-8C40-D2F5F2985F53
title	Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships (en)
page(s)	wds:Q73364992-0A5231B0-EF37-4782-840E-10EA974B5D86
page(s)	5448-5454
instance of	wds:Q73364992-584D33C3-233C-46BD-8DDE-9E3CB81101AA
instance of	scholarly article
main subject	wds:Q73364992-39E8146D-9A51-446F-9CEA-5AFD4AEF9E18
main subject	Trypanosoma cruzi
PubMed ID	wds:Q73364992-16B58FD8-B6DA-42CD-A322-89E11830AC7C
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10639286
PubMed ID	10639286
published in	wds:Q73364992-11198E22-C4F5-4A3A-AB9B-3A81A461D4C3
published in	Journal of Medicinal Chemistry
issue	wds:Q73364992-F5865D31-3200-448A-B76C-07D80A57919A
volume	wds:Q73364992-890249C4-6D03-40DE-B4E9-E8F8D393B0FC
issue	26
volume	42
DOI	wds:Q73364992-860D0B8B-6455-47B0-B524-0252D0A70CB7
DOI	http://dx.doi.org/10.1021/JM990386S
DOI	10.1021/JM990386S
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q73364992
is cites work of	Investigation of trypanothione reductase as a drug target in Trypanosoma brucei Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase Docking and molecular dynamics simulation of quinone compounds with trypanocidal activity. Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei. Pharmacological approaches to prion research Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach Parasite-specific trypanothione reductase as a drug target molecule Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host CoMFA-SIMCA model for antichagasic nitrofurazone derivatives Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma. Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design. Synthesis and anti-inflammatory evaluation of 9-phenoxyacridine and 4-phenoxyfuro[2,3-b]quinoline derivatives. Part 2. The receptor-dependent LQTA-QSAR: application to a set of trypanothione reductase inhibitors CD4+CD45RA-FOXP3low Regulatory T Cells as Potential Biomarkers of Disease Activity in Systemic Lupus Erythematosus Brazilian Patients. Advances in preclinical approaches to Chagas disease drug discovery Design, Synthesis and Evaluation of Bifunctional Acridinine-Naphthalenediimide Redox-Active Conjugates as Antimalarials
is cites work of	wds:Q30897674-AAB233E1-6BBC-4352-9AD1-FFD6A54DB355 wds:Q43256895-1BEF284A-9732-44A5-8244-504432215EA0 wds:Q33933969-06DBF431-89C6-4CCB-AD46-8E5451118E1F wds:Q33419478-D4F0F212-2990-4232-94E2-1310FA64EE42 wds:Q40394480-AD5C673E-9D49-469E-8516-5DEFFFDC539C wds:Q39355235-26206151-6F04-4BD7-A53A-099FE9E6C8CA wds:Q24616801-D28110AF-7567-4F75-B47A-691065007DA2 wds:Q44555592-DF02A198-BCAF-481E-A5AB-42A18C4D590C wds:Q43608956-6F1E8EDE-D784-4363-9748-A2D440CB75BC wds:Q64986418-A8535273-5900-42F3-BA94-E3B8A17EA6ED wds:Q28547882-2E3A7E2A-6636-43F0-84E5-889194C5D360 wds:Q37670897-79D40227-602E-4794-BF94-5ACA42978D23 wds:Q43733836-831B544F-BDF6-4178-A482-E6A1D5F73638 wds:Q40255801-FF39570A-CFE0-41F5-8068-4DDB874A21F6 wds:Q52602457-7B882D6E-CD60-48F1-AE70-539E6DA03C7C wds:Q92610556-5894ED86-00B1-46FE-96A0-A025A3470F35 wds:Q33474992-CAE7531D-2228-41A0-A2FB-F146E74C50AA wds:Q33224951-608DBACB-AFBE-4AF5-AA98-4971DB34EB69 wds:Q46099559-A607C302-FB24-484B-B833-4AC33B036E23 wds:Q58850139-C6E427A2-4FAC-4FF1-BA43-D9DB48BEE4E3 wds:Q84966543-6F3E17DD-B415-4029-A303-31AF51C9D881 wds:Q35112639-EDFE6C5F-E1FB-4E48-BF56-38ECB82C7559 wds:Q56457711-6A571DCA-4D03-47AF-B19C-C185F2DAD9D4 wds:Q34628763-53BF7D59-EA24-4A5C-A630-2B5BD2F7630F wds:Q27690137-A58444BB-B909-4468-B779-7ED7A63BD157 wds:Q33560026-170BEAD3-7A77-4833-A775-9FBC74E096DA wds:Q41813592-347E68EF-BC40-45DA-99C2-4B57D6FBF4F7

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