About: Degradation of alpha-synuclein by proteasome

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scientific article published on 01 November 1999

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в листопаді 1999 (uk) article scientifique publié en 1999 (fr) im November 1999 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 01 November 1999 (en) artículu científicu espublizáu en payares de 1999 (ast)
publication date	wds:Q73195792-4BF80E46-6BC5-4367-A790-E9CDE7C6D918
publication date	1999-11-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q73195792-B99E06F9-3843-446C-9FC6-15673AEB480D
language of work or name	English
author name string	wds:Q73195792-041963A3-6FC5-44BD-89E5-CF7324A4D4CE wds:Q73195792-11E9B55F-4513-4E5E-8B06-B0FAD93010A1 wds:Q73195792-68DBB07D-A7AA-4093-9EAF-29BC48D63443 wds:Q73195792-C84F4808-D18C-4A33-AB34-012AED597D20 wds:Q73195792-D93472FB-5277-41E1-A759-7CD6C9BE8BCE
author name string	J F Bishop T N Chase P B Chock Y Leng M C Bennett
rdfs:label	Degradation of alpha-synuclein by proteasome (en) Degradation of alpha-synuclein by proteasome (nl)
skos:prefLabel	Degradation of alpha-synuclein by proteasome (en) Degradation of alpha-synuclein by proteasome (nl)
name	Degradation of alpha-synuclein by proteasome (en) Degradation of alpha-synuclein by proteasome (nl)
author	wds:Q73195792-C029BFD9-38F9-4469-AEE8-D95B3F2BCB2F
author	M. Maral Mouradian
title	wds:Q73195792-F76FFB62-FD91-4FD0-8073-2D4028B275B6
title	Degradation of alpha-synuclein by proteasome (en)
page(s)	wds:Q73195792-50B9E911-D8C5-4231-AFE2-3E82F957932A
page(s)	33855-33858
instance of	wds:Q73195792-067CE6C4-B604-4258-A969-0E7FA7BD8BE1
instance of	scholarly article
PubMed ID	wds:Q73195792-D3DF15A0-9B4C-4767-9707-F37864024536
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/10567343
PubMed ID	10567343
published in	wds:Q73195792-4AA4343F-4C0E-43C1-8885-9A663C241F6A
published in	Journal of Biological Chemistry
issue	wds:Q73195792-5514B50F-23A5-43E9-8E12-A0AB3BA5D44D
volume	wds:Q73195792-C18E9B5F-BBF9-4E80-A836-13D0AB3AB2FE
issue	48
volume	274
number of pages	wds:Q73195792-52B98EFF-E6D8-437B-848C-561D7CB89458
number of pages	4 (xsd:decimal)
DOI	wds:Q73195792-47A6789F-3699-4B7D-8121-47170D51B429
DOI	http://dx.doi.org/10.1074/JBC.274.48.33855
DOI	10.1074/JBC.274.48.33855
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q73195792
is cites work of	α-Synuclein Is Degraded by Both Autophagy and the Proteasome The role of oxidative stress in Parkinson's disease Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection Upregulation of alpha-synuclein by lipopolysaccharide and interleukin-1 in human macrophages Translocation of alpha-synuclein expressed in Escherichia coli The function of α-synuclein Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration The ubiquitin system: pathogenesis of human diseases and drug targeting Lysosomal degradation of alpha-synuclein in vivo. A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation. Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Induction of alpha-synuclein aggregation by intracellular nitrative insult. Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation The centrosome in human genetic disease Parkinson's disease: one biochemical pathway to fit all genes? The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation The neurotoxin, MPP+, induces hyperphosphorylation of Tau, in the presence of alpha-Synuclein, in SH-SY5Y neuroblastoma cells CD 4+ T cells in the pathobiology of neurodegenerative disorders Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction Exosomal cell-to-cell transmission of alpha synuclein oligomers. Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway Interplay between the ubiquitin-proteasome system and autophagy in proteinopathies. Proteasomal function is impaired in substantia nigra in Parkinson's disease Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. α-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome Genes and parkinsonism Vulnerability of mesostriatal dopaminergic neurons in Parkinson's disease The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility Parkinson's disease and pesticides: a toxicological perspective Brain aging in acquired immunodeficiency syndrome: increased ubiquitin-protein conjugate is correlated with decreased synaptic protein but not amyloid plaque accumulation Neuropathology in mice expressing human alpha-synuclein Protein degradation pathways in Parkinson's disease: curse or blessing In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility Ubiquitin-dependent proteolysis: its role in human diseases and the design of therapeutic strategies Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations

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