About: Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation

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About: Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation Goto Sponge NotDistinct Permalink

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scientific article published on 01 December 1993

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в грудні 1993 (uk) article scientifique publié en 1993 (fr) im Dezember 1993 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'avientu de 1993 (ast) scientific article published on 01 December 1993 (en)
publication date	wds:Q72633063-2FC5DED1-19FB-4169-AED0-BDEF7D46C628
publication date	1993-12-01 00:00:00Z (xsd:dateTime)
author name string	wds:Q72633063-74191D98-3F45-4E40-8C5E-EDD3BB864416 wds:Q72633063-96F1B332-A7BD-481E-B1E8-5CBCB7213D16 wds:Q72633063-A5E35001-39E3-4CE3-98B9-83DC049269C5 wds:Q72633063-ADA99686-398D-4C04-ADBA-E476AE7DBAC8 wds:Q72633063-E47D6940-7197-4635-8515-E02A2FF8881D
author name string	M Murata D J Buttle J Saklatvala C J Handley M Z Ilic
rdfs:label	Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation (en) Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation (nl)
skos:prefLabel	Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation (en) Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation (nl)
name	Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation (en) Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation (nl)
author	wds:Q72633063-0CFB076E-B93D-45A1-9E94-8F271BD6785A
author	Alan J. Barrett
title	wds:Q72633063-8E4143AC-0CDF-48C8-A103-DC7CB80CC6CC
title	Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation (en)
page(s)	wds:Q72633063-388B14E3-1FA1-4BC3-95E6-35C916F2D820
page(s)	1709-1717
instance of	wds:Q72633063-C9FB545B-F2B2-405B-932F-8B1662CF2A5F
instance of	scholarly article
PubMed ID	wds:Q72633063-0000AEC4-E025-45DF-B1A2-2271D3FE81E8
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8250991
PubMed ID	8250991
published in	wds:Q72633063-59F14FCC-261B-499D-8DE6-0E4F48796593
published in	Arthritis and Rheumatism
issue	wds:Q72633063-1403C50D-6114-491F-BF93-9669020C7FDE
volume	wds:Q72633063-41AFF2BC-C9AA-4B1F-8D8A-1149045CAF3C
issue	12
volume	36
DOI	wds:Q72633063-A8830D26-5E5D-4FEF-AB38-FFA2A7FBEA4F
DOI	http://dx.doi.org/10.1002/ART.1780361210
DOI	10.1002/ART.1780361210
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q72633063
is cites work of	Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent Structure and function of aggrecan Upregulation of enzymatic activity by interleukin-1 in osteoarthritis Inhibitors of collagenase but not of gelatinase reduce cartilage explant proteoglycan breakdown despite only low levels of matrix metalloproteinase activity Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes. Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine Cathepsin B in osteoarthritis: cytochemical and histochemical analysis of human femoral head cartilage Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L. Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation Expression of membrane-type 1 matrix metalloproteinase and activation of progelatinase A in human osteoarthritic cartilage. Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritis Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH. Analysing the role of endogenous matrix molecules in the development of osteoarthritis. Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin. Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage Activation of procollagenases is a key control point in cartilage collagen degradation: interaction of serine and metalloproteinase pathways "Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease Optimizing dentin bond durability: control of collagen degradation by matrix metalloproteinases and cysteine cathepsins Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor Characterization of aggrecan retained and lost from the extracellular matrix of articular cartilage. Involvement of carboxyl-terminal processing in the catabolism of aggrecan. Temporal pattern of cysteine endopeptidase (cathepsin B) expression in cartilage and synovium from rabbit knees with experimental osteoarthritis: gene expression in chondrocytes in response to interleukin-1 and matrix depletion Differential Expression of Aggrecanase and Matrix Metalloproteinase Activity in Chondrocytes Isolated from Bovine and Porcine Articular Cartilage Appearance of calpain correlates with arthritis and cartilage destruction in collagen induced arthritic knee joints of mice In vivo model of cartilage degradation--effects of a matrix metalloproteinase inhibitor Inhibition of relaxin-induced pubic symphyseal "relaxation" in guinea pigs by glycosaminoglycan polysulfates and pentosan polysulfate. Effects of long-term exposure to glucosamine and mannosamine on aggrecan degradation in articular cartilage Stromelysin 1, neutrophil collagenase, and collagenase 3 do not play major roles in a model of chondrocyte mediated cartilage breakdown Metalloproteinase production by rabbit articular cartilage: comparison of the effects of interleukin-1 alpha in vitro and in vivo. Retinoic acid-induced type II collagen degradation does not correlate with matrix metalloproteinase activity in cartilage explant cultures Proteolytic mechanisms of cartilage breakdown: a target for arthritis therapy? Immunolocalization of cathepsin B in equine dyschondroplastic articular cartilage Octa-O-bis-(R,R)-Tartarate Ditellurane (SAS) - a novel bioactive organotellurium(IV) compound: synthesis, characterization, and protease inhibitory activity Proteoglycan breakdown from bovine nasal cartilage is increased, and from articular cartilage is decreased, by extracellular ATP. Osteochondrosis and copper: histology of articular cartilage from foals out of copper supplemented and non-supplemented dams. Pharmacological effect of tetracyclines on proteoglycanases from interleukin-1-treated articular cartilage Degradation of bovine cartilage proteoglycan in vitro is enhanced by inhibition of nitric oxide synthase Isothiazolones interfere with normal matrix metalloproteinase activation and inhibit cartilage proteoglycan degradation Disease-modifying anti-osteoarthritic drugs: current therapies and new prospects around protease inhibition Dithiocarbamates inhibit IL-1-induced cartilage degradation in bovine articular cartilage explants Effects of an inhibitor of cathepsin L on bone resorption in thyroparathyroidectomized and ovariectomized rats Multiple matrix metalloproteinases in type II collagen induced arthritis Evidence that the inhibition of cartilage proteoglycan breakdown by mannosamine is not mediated via inhibition of glycosylphosphatidylinositol anchor formation The proteoglycan metabolism, morphology and viability of articular cartilage treated with a synthetic matrix metalloproteinase inhibitor
is cites work of	wds:Q27730414-829B3862-A9B6-42A4-B270-36D76DF1773F wds:Q40727168-B2552976-3DFE-49B6-B232-12DBA6E6B24F

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