About: Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts

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About: Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts Goto Sponge NotDistinct Permalink

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scientific article published on 01 April 1994

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) bài báo khoa học (vi) наукова стаття, опублікована у квітні 1994 (uk) im April 1994 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'abril de 1994 (ast) scientific article published on 01 April 1994 (en)
publication date	wds:Q72344021-4DE6E195-2AC9-4EE3-8A82-DC6924595002
publication date	1994-04-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q72344021-60265865-2C47-4A1A-9E79-5FCF657DD417
language of work or name	English
author name string	wds:Q72344021-40744702-06BC-431D-90D7-7676D7C48073 wds:Q72344021-AD44F6F7-F7AF-427B-8C73-FEB3D13282A9
author name string	J E Cochrane T R Skopek
rdfs:label	Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts (en) Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts (nl)
skos:prefLabel	Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts (en) Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts (nl)
name	Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts (en) Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts (nl)
title	wds:Q72344021-DFE7E32E-F66F-4857-9EDB-1BABA14B4BE0
title	Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts (en)
page(s)	wds:Q72344021-3621C23B-5EFC-45B3-9B07-4A7EAEE39C8E
page(s)	713-717
instance of	wds:Q72344021-9DC3D0A1-3A30-43A3-935D-7B0F9D498E94
instance of	scholarly article
PubMed ID	wds:Q72344021-7ED47DC4-D0E1-4CA7-990E-00405B5630D4
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8149485
PubMed ID	8149485
published in	wds:Q72344021-14B13228-A127-472A-BFAD-566BF712EB14
published in	Carcinogenesis
issue	wds:Q72344021-CD06B4DB-CE33-4FFA-B6FA-DC1CC99A9885
volume	wds:Q72344021-DB7CCDA7-D69A-4746-B6DD-4865C446FD3C
issue	4
volume	15
DOI	wds:Q72344021-044051BB-F247-42E2-B6AC-0F932BCBB888
DOI	http://dx.doi.org/10.1093/CARCIN/15.4.713
DOI	10.1093/CARCIN/15.4.713
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q72344021
is cites work of	Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions Assessment of 1,3-butadiene exposure in polymer production workers using HPRT mutations in lymphocytes as a biomarker Bis-butanediol-mercapturic acid (bis-BDMA) as a urinary biomarker of metabolic activation of butadiene to its ultimate carcinogenic species Quantitative analysis of trihydroxybutyl mercapturic acid, a urinary metabolite of 1,3-butadiene, in humans Response of transposable elements to environmental stressors Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene Butadiene-induced intrastrand DNA cross-links: a possible role in deletion mutagenesis Translesion DNA synthesis by yeast DNA polymerase eta on templates containing N2-guanine adducts of 1,3-butadiene metabolites Capillary HPLC-accurate mass MS/MS quantitation of N7-(2,3,4-trihydroxybut-1-yl)-guanine adducts of 1,3-butadiene in human leukocyte DNA Molecular dosimetry of 1,2,3,4-diepoxybutane-induced DNA-DNA cross-links in B6C3F1 mice and F344 rats exposed to 1,3-butadiene by inhalation NanoHPLC-nanoESI(+)-MS/MS quantitation of bis-N7-guanine DNA-DNA cross-links in tissues of B6C3F1 mice exposed to subppm levels of 1,3-butadiene Increased frequency of mutations at A:T base pairs in the bone marrow of B6C3F1 lacI transgenic mice exposed to 1,3-butadiene. DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene. Genetic and reproductive toxicity of butadiene and isoprene. Quantitation of DNA adducts by stable isotope dilution mass spectrometry 1,3-Butadiene: Biomarkers and application to risk assessment Replication past the butadiene diepoxide-derived DNA adduct S-[4-(N(6)-deoxyadenosinyl)-2,3-dihydroxybutyl]glutathione by DNA polymerases Quantitative high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry analysis of the adenine-guanine cross-links of 1,2,3,4-diepoxybutane in tissues of butadiene-exposed B6C3F1 mice Column switching HPLC-ESI(+)-MS/MS methods for quantitative analysis of exocyclic dA adducts in the DNA of laboratory animals exposed to 1,3-butadiene Exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, structural elucidation, and mechanistic studies Specific DNA adducts induced by some mono-substituted epoxides in vitro and in vivo DNA oligomers containing site-specific and stereospecific exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, characterization, and effects on DNA structure Mutational spectrum of 1,3-butadiene and metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane to assess mutagenic mechanisms Variability in human sensitivity to 1,3-butadiene: Influence of the allelic variants of the microsomal epoxide hydrolase gene Comparison of the disposition of butadiene epoxides in Sprague-Dawley rats and B6C3F1 mice following a single and repeated exposures to 1,3-butadiene via inhalation Using DNA and hemoglobin adducts to improve the risk assessment of butadiene Reaction of 1,2,3,4-diepoxybutane with 2'-deoxyguanosine: initial products and their stabilities and decomposition patterns under physiological conditions Characterization of 1,2,3,4-diepoxybutane-2'-deoxyguanosine cross-linking products formed at physiological and nonphysiological conditions Quantitative PCR analysis of diepoxybutane and epihalohydrin damage to nuclear versus mitochondrial DNA. Germ cell mutagenicity of three metabolites of 1,3-butadiene in the rat: induction of spermatid micronuclei by butadiene mono-, di-, and diolepoxides in vivo Alcohol dehydrogenase- and rat liver cytosol-dependent bioactivation of 1-chloro-2-hydroxy-3-butene to 1-chloro-3-buten-2-one, a bifunctional alkylating agent Cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene and 1-chloro-3-buten-2-one, two alternative metabolites of 1,3-butadiene The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene Biomonitoring of 1,3-butadiene and related compounds 1,N2-Propanodeoxyguanosine Adducts of the 1,3-Butadiene Metabolite, Hydroxymethylvinyl Ketone Structure of the 1,4-bis(2'-deoxyadenosin-N6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide Covalent DNA-Protein Cross-Linking by Phosphoramide Mustard and Nornitrogen Mustard in Human Cells Urinary butadiene diepoxide: a potential biomarker of blood diepoxide The in vivo mutagenicity and mutational spectrum at the lacI transgene recovered from the spleens of B6C3F1 lacI transgenic mice following a 4-week inhalation exposure to 1,3-butadiene. Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane Insights into the toxicokinetics and toxicodynamics of 1,3-butadiene Cellular and molecular basis for species, sex and tissue differences in 1,3-butadiene metabolism Genetic effects of 1,3-butadiene and associated risk for heritable damage. Micronucleus induction in germ and somatic cells of the mouse after exposure to the butadiene metabolites diepoxybutane and epoxybutene Clastogenic effects of 1,3-butadiene and its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in splenocytes and germ cells of rats and mice in vivo Comparison of induction of hprt mutations by 1,3-butadiene and/or its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in lymphocytes from spleen of adult male mice and rats in vivo Reproductive toxicity of 1,3-butadiene in the mouse: cytogenetic analysis of chromosome aberrations in first-cleavage embryos and flow cytometric evaluation of spermatogonial cell killing Mass Spectrometry-Based Tools to Characterize DNA-Protein Cross-Linking by Bis-Electrophiles Monophosphate 32P-postlabeling assay of DNA adducts from 1,2:3,4-diepoxybutane, the most genotoxic metabolite of 1,3-butadiene: in vitro methodological studies and in vivo dosimetry Disposition of butadiene epoxides in Sprague-Dawley rats Genotoxicity and cytotoxicity in male B6C3F1 mice following exposure to mixtures of 1,3-butadiene and styrene Conjugation of butadiene diepoxide with glutathione yields DNA adducts in vitro and in vivo Diepoxybutane cytotoxicity on mouse germ cells is enhanced by in vivo glutathione depletion: a flow cytometric approach Species differences in the metabolism of olefins: implications for risk assessment Characterization of Hprt mutations in cDNA and genomic DNA of T-cell mutants from control and 1,3-butadiene-exposed male B6C3F1 mice and F344 rats In vitro genotoxicity testing of (1-chloroethenyl)oxirane, a metabolite of beta-chloroprene Mutagenicity of a glutathione conjugate of butadiene diepoxide Mutagenic bypass of the butadiene-derived 2'-deoxyuridine adducts by polymerases eta and zeta Butadiene: species comparison for metabolism and genetic toxicology

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