About: Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity

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About: Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity Goto Sponge NotDistinct Permalink

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scientific article published on 01 August 1995

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в серпні 1995 (uk) article scientifique publié en 1995 (fr) im August 1995 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'agostu de 1995 (ast) scientific article published on 01 August 1995 (en)
publication date	wds:Q71706996-4AFB605D-3057-47DE-9846-AF1897B74DD2
publication date	1995-08-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q71706996-46BB2254-8CA5-4D38-9DAE-8BDC4FA42063
language of work or name	English
cites work	wds:Q71706996-251DC387-96C1-40BD-AA11-E49BACB72069 wds:Q71706996-25EA3629-1014-49AF-8369-E9036BD3DF22 wds:Q71706996-35184D71-B32C-4A32-9F3B-CBE7AF8D6C07 wds:Q71706996-3A1FFE73-8484-4AAF-9B59-B8C74C422438 wds:Q71706996-429C6B36-C185-4A57-81FE-40EB029ACCC6 wds:Q71706996-5B43E342-3688-4E03-846D-4BDB5B0EDFB9 wds:Q71706996-60046FE8-B07C-48DD-A559-E2BC58ECB411 wds:Q71706996-6880574D-418B-4454-ACE5-4D977A5826FA wds:Q71706996-6FB3473B-A725-4F75-AA7A-2465B0720EFA wds:Q71706996-7AEA1DE6-9990-4A87-BBFE-E7A89FD6506A wds:Q71706996-8DF5CEB3-482C-4495-AFFA-F72847056E70 wds:Q71706996-9098276B-A61D-4523-8478-59C9EB7A12D7 wds:Q71706996-978B233E-11B5-44A8-93C1-40C63916F080 wds:Q71706996-AE5D1AD4-4414-4533-8B56-0D5A9E0A88C6 wds:Q71706996-B2E98303-43FA-48F8-B3CF-5620DE539DED wds:Q71706996-BC6118A1-17E8-4DC5-8FBC-2C3D094D9480 wds:Q71706996-F63AF235-7913-41B1-A66A-3DE5DC300908 wds:Q71706996-FE7A844C-FCC9-4513-94D1-E4277F1AAFFF
cites work	Elementary steps in the DNA polymerase I reaction pathway The kinetics of enzyme-catalyzed reactions with two or more substrates or products Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance Identification and amino acid sequence of the deoxynucleoside triphosphate binding site in Escherichia coli DNA polymerase I. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA Rapid and efficient site-specific mutagenesis without phenotypic selection Deoxynucleoside triphosphate and pyrophosphate binding sites in the catalytically competent ternary complex for the polymerase reaction catalyzed by DNA polymerase I (Klenow fragment). Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor Numbers of Receptor Sites from Scatchard Graphs: Facts and Fantasies Isolation and characterization of a dideoxyguanosine triphosphate-resistant mutant of human immunodeficiency virus reverse transcriptase Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not. Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity Mechanism of resistance of human immunodeficiency virus type 1 to 2',3'-dideoxyinosine Mutational analysis of two conserved sequence motifs in HIV-1 reverse transcriptase Photoaffinity labeling of the thymidine triphosphate binding domain in Escherichia coli DNA polymerase I: identification of histidine-881 as the site of cross-linking. Biosynthesis and analysis of a genetically engineered HIV-1 reverse transcriptase/endonuclease polyprotein in Escherichia coli
author name string	wds:Q71706996-6A70AB1C-4A2D-48D3-AAB1-F183FB3FFE97 wds:Q71706996-B9B200E0-77D4-49B0-915C-359622FCA392 wds:Q71706996-EA5BA615-35F3-472D-BBAA-032C4E4FB516
author name string	M J Modak V N Pandey N Kaushik
rdfs:label	Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity (en) Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity (nl)
skos:prefLabel	Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity (en) Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity (nl)
name	Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity (en) Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity (nl)
author	wds:Q71706996-0CE73330-1BC0-402B-865D-AA875E7754E5
author	Stefan G. Sarafianos
title	wds:Q71706996-C271EB38-6A99-49D0-9007-196860809CE1
title	Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity (en)
page(s)	wds:Q71706996-1826165E-EA17-4126-BFE3-3D04C556C818
page(s)	19729-19735
instance of	wds:Q71706996-11139A7A-A553-4A4B-9B6A-1D8F3C13A262
instance of	scholarly article
PubMed ID	wds:Q71706996-D79C48B4-8F20-4BD1-AC85-8BC735B0A2AC
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/7544345
PubMed ID	7544345
published in	wds:Q71706996-53EF87E3-4316-4F19-82B4-F1866CD82485
published in	Journal of Biological Chemistry
issue	wds:Q71706996-89BC93C5-3C7B-4E4C-ABA8-54CE6FDF78EA
volume	wds:Q71706996-FB2DD767-5F30-4313-868D-85C944092B45
issue	34
volume	270
DOI	wds:Q71706996-759D73A6-2FD8-4B16-9B31-39C85981AEAF
DOI	http://dx.doi.org/10.1074/JBC.270.34.19729
DOI	10.1074/JBC.270.34.19729
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q71706996
is cites work of	Functional analysis of amino acid residues constituting the dNTP binding pocket of HIV-1 reverse transcriptase Biochemical mechanism of HIV-1 resistance to rilpivirine Functional analysis of conserved residues in the putative "finger" domain of telomerase reverse transcriptase K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA. Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations Structural determinants of murine leukemia virus reverse transcriptase that affect the frequency of template switching HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently Structural basis for activation of α-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site Template definition by Tetrahymena telomerase reverse transcriptase Mutation rates and intrinsic fidelity of retroviral reverse transcriptases. Viral quasispecies and the problem of vaccine-escape and drug-resistant mutants. Uniquely altered DNA replication fidelity conferred by an amino acid change in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase Mutational analysis of Lys65 of HIV-1 reverse transcriptase Molecular basis of fidelity of DNA synthesis and nucleotide specificity of retroviral reverse transcriptases Differential tolerance to DNA polymerization by HIV-1 reverse transcriptase on N6 adenine C10R and C10S benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide-adducted templates Inhibitors of HIV-1 reverse transcriptase

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