About: Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial

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About: Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial Goto Sponge NotDistinct Permalink

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scientific article published on 01 October 1996

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) bài báo khoa học (vi) наукова стаття, опублікована в жовтні 1996 (uk) article scientifique publié en 1996 (fr) im Oktober 1996 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'ochobre de 1996 (ast) scientific article published on 01 October 1996 (en)
publication date	wds:Q71611794-5DA230C9-D0A4-452B-A2F5-EA2B1312CB94
publication date	1996-10-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q71611794-3E215F8D-A820-4830-813A-E39F152A3528
language of work or name	English
author name string	wds:Q71611794-3B3B6BA2-F2FF-4DE9-A2CA-EBC983FB00AF wds:Q71611794-59E6B073-7A9A-42F0-B1FA-A93CF5138254 wds:Q71611794-5D51DB52-A720-4E42-990D-341021428185 wds:Q71611794-602F9048-2FDB-4145-82D2-068B459CC075 wds:Q71611794-A3E1D50D-ED65-44CF-A2F6-D8BBCE555C40 wds:Q71611794-C5E177A9-545B-4E8A-B79A-E6C705571E45 wds:Q71611794-E887CBD5-6BD8-4300-BB6E-0D3C9449FFF3 wds:Q71611794-F70E2967-EA4A-40EE-8785-6E0725F7A0E0 wds:Q71611794-FDEFBD84-7523-4EA0-A1B1-18E38BB86EFB
author name string	Kyle RA Liu P Kay NE Oken MM Quam L Van Ness B Billadeau D Greipp P Leong T
rdfs:label	Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial (en) Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial (nl)
skos:prefLabel	Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial (en) Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial (nl)
name	Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial (en) Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial (nl)
title	wds:Q71611794-F47D1C05-ECD7-46C6-9A33-0872CEA1CB06
title	Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial (en)
page(s)	wds:Q71611794-C6D3C005-8329-462D-BE74-8A55E70C675E
page(s)	2699-2706
instance of	wds:Q71611794-F2CE5771-4D6A-4B3B-B280-6CBCA73A03E8
instance of	scholarly article
main subject	wds:Q71611794-22BC19FE-BF29-49D3-BBBA-4C9F6F04494D wds:Q71611794-BE082000-D97F-4EAC-963C-506B1130333D
main subject	multiple myeloma phase III clinical trial
PubMed ID	wds:Q71611794-2FEDE7DA-8CE8-4B8F-8A90-6D4CDC4265DB
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8839865
PubMed ID	8839865
published in	wds:Q71611794-FE9A88C4-5796-491C-87F6-09F8DB3FBA92
published in	Blood
issue	wds:Q71611794-DF6F3184-BE37-489F-AC38-110575EDC3DC
volume	wds:Q71611794-84ADAE8B-DFBC-48CA-942E-EF5F7BB1E6DB
issue	7
volume	88
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q71611794
is cites work of	International Myeloma Working Group molecular classification of multiple myeloma: spotlight review. Multiple myeloma: increasing evidence for a multistep transformation process Multistep Tumorigenesis of Multiple Myeloma: Its Molecular Delineation Targeting oncogenic Ras signaling in hematologic malignancies Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma Genetic events in the pathogenesis of multiple myeloma Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy Germinal center B-cells resist transformation by Kras independently of tumor suppressor Arf IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo Molecular aspects of multiple myeloma Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies A phase II trial of BAY 43-9006 (sorafenib) (NSC-724772) in patients with relapsing and resistant multiple myeloma: SWOG S0434. MEK inhibitors as a chemotherapeutic intervention in multiple myeloma Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells. Resequencing analysis of the candidate tyrosine kinase and RAS pathway gene families in multiple myeloma Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs Emerging therapies for multiple myeloma The interplay of reovirus with autophagy Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma Multiple myeloma acquires resistance to EGFR inhibitor via induction of pentose phosphate pathway Expression profile of telomere-associated genes in multiple myeloma. Cell of Origin and Genetic Alterations in the Pathogenesis of Multiple Myeloma. Molecular biology of myeloma. Oncolytic virotherapy for multiple myeloma: past, present, and future Oscillating expression of interleukin-16 in multiple myeloma is associated with proliferation, clonogenic growth, and PI3K/NFKB/MAPK activation Diagnosing imputation models by applying target analyses to posterior replicates of completed data Human MutT homologue 1 mRNA overexpression correlates to poor response of multiple myeloma Evaluation and management of skeletal disease in cancer care. Constitutive Activation of STAT3 in Myeloma Cells Cultured in a Three-Dimensional, Reconstructed Bone Marrow Model. IQGAP1 Scaffold-MAP Kinase Interactions Enhance Multiple Myeloma Clonogenic Growth and Self-Renewal Isolation of circulating plasma cells from blood of patients diagnosed with clonal plasma cell disorders using cell selection microfluidics. Rare SNPs in receptor tyrosine kinases are negative outcome predictors in multiple myeloma Recurrent mutations of MAPK pathway genes in multiple myeloma but not in amyloid light-chain amyloidosis. Analysis of the expressed immunoglobulin variable region heavy chain gene products in paraproteins from Iranian patients with multiple myeloma Survival rate of multiple myeloma patients in Indonesia: A retrospective study in multiple myeloma at a single institution Exon-4 Mutations in KRAS Affect MEK/ERK and PI3K/AKT Signaling in Human Multiple Myeloma Cell Lines Targeted overexpression of an activated N-ras gene results in B-cell and plasma cell lymphoproliferation and cooperates with c-myc to induce fatal B-cell neoplasia
is cites work of	wds:Q41670812-C3033EF4-6F68-4190-A7F4-C311CA544356 wds:Q38803056-9FC313AB-69C6-45B5-9747-0632F6E446AD wds:Q33415840-64C781F0-ABB6-45C3-B743-7FA43005CDE0

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