About: Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor

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About: Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor Goto Sponge NotDistinct Permalink

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scientific article published on 01 September 1996

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована у вересні 1996 (uk) article scientifique publié en 1996 (fr) im September 1996 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en setiembre de 1996 (ast) scientific article published on 01 September 1996 (en)
publication date	wds:Q71514922-54869FC6-4E27-447F-85EC-D2F72831A66D
publication date	1996-09-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q71514922-4D24E355-EA25-466A-92F8-ABEAD17542CB
language of work or name	English
author name string	wds:Q71514922-33D677C6-C9F2-4110-8199-E7CA8F1664F1 wds:Q71514922-643056AF-1C58-4524-9E4D-E10B63BA44FC wds:Q71514922-7C1A554F-3DD0-42EB-A595-4D95E8F4C234 wds:Q71514922-AC49F37C-2F13-43A2-8577-156E802636F9 wds:Q71514922-C89EE44E-14E0-4634-B066-25A8C9EA7701
author name string	M Johnson S B Liggett R A Coleman S A Green A P Spasoff
rdfs:label	Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor (en) Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor (nl)
skos:prefLabel	Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor (en) Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor (nl)
name	Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor (en) Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor (nl)
title	wds:Q71514922-04A2B3A0-C72B-4D48-AD9B-440E00FB1B7C
title	Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor (en)
page(s)	wds:Q71514922-59A460E9-9020-4C29-8622-BDD374B654EC
page(s)	24029-24035
instance of	wds:Q71514922-E4BA5115-EBE9-4755-ABE8-D5508603BA6F
instance of	scholarly article
main subject	wds:Q71514922-7D496C57-4CE3-4827-8B0F-E2C364A5CD88
main subject	G protein-coupled receptor
PubMed ID	wds:Q71514922-63431FA5-3574-4CA6-868A-E37884E9D562
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8798639
PubMed ID	8798639
published in	wds:Q71514922-1B32AE4B-8A0E-43DD-90F6-1E433EAC66C5
published in	Journal of Biological Chemistry
issue	wds:Q71514922-7DBC90ED-FF5D-4B81-8F8A-1547E479D48B
volume	wds:Q71514922-E21419CA-F0C7-46BC-9180-74F19EC3F142
issue	39
volume	271
DOI	wds:Q71514922-DBB1900B-9665-4722-B5CC-0FFF9B6395BB
DOI	http://dx.doi.org/10.1074/JBC.271.39.24029
DOI	10.1074/JBC.271.39.24029
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q71514922
is cites work of	Salmeterol restores secretory functions in cystic fibrosis airway submucosal gland serous cells Can residence time offer a useful strategy to target agonist drugs for sustained GPCR responses? Differential contribution of two serine residues of wild type and constitutively active beta2-adrenoceptors to the interaction with beta2-selective agonists A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA Modelling G-protein-coupled receptors for drug design Allosteric modulators of class B G-protein-coupled receptors Role of beta ARK in long-term agonist-promoted desensitisation of the beta 2-adrenergic receptor Beta-adrenoceptor agonists and asthma--100 years of development Pharmacology and direct visualisation of BODIPY-TMR-CGP: a long-acting fluorescent beta2-adrenoceptor agonist Current issues with beta2-adrenoceptor agonists: pharmacology and molecular and cellular mechanisms Formoterol 12 microg BID administered via single-dose dry powder inhaler in adults with asthma suboptimally controlled with salmeterol or on-demand salbutamol: a multicenter, randomized, open-label, parallel-group study The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor Canadian Asthma Consensus Report, 1999. Canadian Asthma Consensus Group Label-Free Receptor Assays Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization Salmeterol-induced desensitization, internalization and phosphorylation of the human beta2-adrenoceptor Salmeterol. A review of its pharmacological properties and clinical efficacy in the management of children with asthma Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha) S 14506: novel receptor coupling at 5-HT(1A) receptors. Three-dimensional pharmacology, a subject ranging from ignorance to overstatements Altering airway surface liquid volume: inhalation therapy with amiloride and hyperosmotic agents Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach Pharmacology of bronchodilators used in the treatment of COPD. Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivo Clinical pharmacokinetics of salmeterol Molecular mechanisms for the persistent bronchodilatory effect of the beta 2-adrenoceptor agonist salmeterol Agonist-specific patterns of beta 2-adrenoceptor responses in human airway cells during prolonged exposure The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). Pharmacotherapies for COPD. Influence of receptor number on the stimulation by salmeterol of gene transcription in CHO-K1 cells transfected with the human beta2-adrenoceptor A benefit-risk assessment of inhaled long-acting beta2-agonists in the management of obstructive pulmonary disease Ligands, their receptors and ... plasma membranes Hydrolysis of aromatic β-glucosides by non-pathogenic bacteria confers a chemical weapon against predators. Salmeterol/fluticasone propionate combination Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity A cell-based assay to assess the persistence of action of agonists acting at recombinant human beta(2) adrenoceptors Structural insights into binding specificity, efficacy and bias of a βAR partial agonist G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands Identifying ligand binding conformations of the β2-adrenergic receptor by using its agonists as computational probes Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity Influence of salmeterol and benzalkonium chloride on G-protein-mediated exocytotic responses of rat peritoneal mast cells [Beta-agonists in the treatment of bronchial asthma] The luminescent HiBiT peptide enables selective quantitation of GPCR ligand engagement and internalization in living cells Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action. Local versus systemic effects of inhaled drugs Does the lipid bilayer orchestrate access and binding of ligands to transmembrane orthosteric/allosteric sites of GPCRs? Turning a molecule into a medicine: the development of indacaterol as a novel once-daily bronchodilator treatment for patients with COPD. Domains of beta1 and beta2 adrenergic receptors to bind subtype selective agonists Dose-response relationships in determining the safety:efficacy ratio

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