About: Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I

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About: Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I Goto Sponge NotDistinct Permalink

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scientific article published on 01 January 1996

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) articolo scientifico (pubblicato il 1996) (it) наукова стаття, опублікована в січні 1996 (uk) article scientifique publié en 1996 (fr) im Januar 1996 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en xineru de 1996 (ast) artikull shkencor i botuar më 01 janar 1996 (sq) scientific article published on 01 January 1996 (en)
publication date	wds:Q70915257-39FE5515-F5ED-4DC0-9505-0E51D273EC49
publication date	1996-01-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q70915257-88D3400F-1E15-412F-9C4D-1D3E545F6CB4
language of work or name	English
cites work	wds:Q70915257-0630377E-E03C-42DB-A1E1-3E7452D20C3F wds:Q70915257-131CC05F-9BF7-43A4-BBD2-3BBCA5945CE0 wds:Q70915257-21EA0C31-3D5B-4CFD-B504-3024A0946083 wds:Q70915257-36219D64-A960-46E3-9162-A4E6E25CF26B wds:Q70915257-38107739-2CDA-44BB-BD44-563270291B26 wds:Q70915257-55967995-3BF5-48F6-B886-5EDAB8C3E06B wds:Q70915257-5A439A6E-33B9-4E19-834A-5B5F48731C70 wds:Q70915257-60BA982E-1BFA-46B8-9BD1-95474F715839 wds:Q70915257-65937954-1062-4DA2-95CF-3AC85DFD9578 wds:Q70915257-6633C29C-6BEB-47FF-81AA-21D50F6926EC wds:Q70915257-6EC46B17-A780-4625-9D8C-267E1F7F2F44 wds:Q70915257-7B1C162C-FA49-4931-9F39-0E60BA530816 wds:Q70915257-822A044B-6999-4395-8DC4-49A84BD6244C wds:Q70915257-929E8EB4-4615-448B-A4BD-BF2D56E8D7CB wds:Q70915257-943E82A3-0F27-4D46-9AFE-42FF33D4F781 wds:Q70915257-9870C211-AF08-440F-B8F8-AE62F0F09C1A wds:Q70915257-9925EA0C-14E7-44E8-A6D7-E27CC37CF1AF wds:Q70915257-9F4961D7-3CA1-4021-82D1-D53F33028E51 wds:Q70915257-AAD64C66-B3D0-4190-8DD4-DA6FC1FBF333 wds:Q70915257-AE62A531-BF3A-41BF-9E70-4868F98F36AF wds:Q70915257-BA6C951A-3EE6-430B-A159-0EF10715E328 wds:Q70915257-BB192272-FE52-4EF6-A709-5AC80C1B16A2 wds:Q70915257-C384FBFA-A786-44B1-9AEA-42A6CB585678 wds:Q70915257-DA877A21-C0D2-407F-B3A3-1869DB63B556 wds:Q70915257-E3EC63B2-4772-4512-9F35-6F655831A34F wds:Q70915257-E4E5C6AB-A3AB-4155-A668-2AD9C356F64B wds:Q70915257-F03D81FE-0FC4-4A44-98BD-E6E867423F3C
cites work	A strategy for identifying novel, mechanistically unique inhibitors of topoisomerase I Topoisomerase poisons: harnessing the dark side of enzyme mechanism. On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships The effect of quercetin on cell cycle progression and growth of human gastric cancer cells Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol DNA topoisomerase poisons as antitumor drugs Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures Synergistic antiproliferative activity of quercetin and cisplatin on ovarian cancer cell growth Strand scission in DNA induced by quercetin and Cu(II): role of Cu(I) and oxygen free radicals Crystal structure determination at 2.3-A resolution of human transthyretin-3',5'-dibromo-2',4,4',6-tetrahydroxyaurone complex New technique for uncoupling the cleavage and religation reactions of eukaryotic topoisomerase I. The mode of action of camptothecin at a specific recognition site Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives The current status of camptothecin analogues as antitumor agents Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus Preferential relaxation of supercoiled DNA containing a hexadecameric recognition sequence for topoisomerase I. The effects of the bioflavonoid quercetin on squamous cell carcinoma of head and neck origin Suppression of active oxygen-induced cytotoxicity by flavonoids Acidic phospholipids directly inhibit DNA binding of mammalian DNA topoisomerase I. Enhancement of the antiproliferative activity of cis-diamminedichloroplatinum(II) by quercetin Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice. The combination of quercetin and cytosine arabinoside synergistically inhibits leukemic cell growth Antiproliferative activity of quercetin on normal bone marrow and leukaemic progenitors
author name string	wds:Q70915257-159962F6-7D26-48A8-BD96-5F34147DEC70 wds:Q70915257-954DEE86-97C3-4ECD-A894-71D8A0ACDEE5 wds:Q70915257-AAC616E1-951C-4A1B-8A87-5F1A77BE1E34 wds:Q70915257-C648DBCC-678B-41AC-AFAD-91EF30147F83 wds:Q70915257-DFF7A3AE-CA59-4414-82A6-F44F9FB3BE97 wds:Q70915257-E60956E9-BFE2-4E80-8826-C8DDDF1A1A78
author name string	F Boege A Andersen F Jakob K Christiansen A Kehr C Boesenberg
rdfs:label	Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I (en) Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I (nl) Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I (sq)
skos:prefLabel	Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I (en) Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I (nl) Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I (sq)
name	Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I (en) Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I (nl) Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I (sq)
author	wds:Q70915257-78A909E9-6FD3-40EB-A4EC-109E66B131D1 wds:Q70915257-F56AFFAD-37CD-4B55-A7F0-63E0CA675D2F
author	Josef Köhrle Tobias Straub
title	wds:Q70915257-1D18A805-E758-47C0-9749-0F9FBC5BC7D6
title	Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I (en)
page(s)	wds:Q70915257-72D2A93F-B7A1-4612-A21F-CFB878A84097
page(s)	2262-2270
instance of	wds:Q70915257-5FED3866-B814-4D06-8D25-BA6F98F35024
instance of	scholarly article
PubMed ID	wds:Q70915257-8FF62955-84B5-443A-A8C5-D5E29F4509B4
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8567688

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