About: Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds

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About: Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds Goto Sponge NotDistinct Permalink

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scientific article published on 01 September 1988

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) bài báo khoa học (vi) наукова стаття, опублікована у вересні 1988 (uk) article scientifique publié en 1988 (fr) im September 1988 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en setiembre de 1988 (ast) scientific article published on 01 September 1988 (en)
publication date	wds:Q70075186-D5CC392B-9790-4D56-AB5C-B18CB381DCBD
publication date	1988-09-01 00:00:00Z (xsd:dateTime)
author name string	wds:Q70075186-2844E805-C434-4C7C-98AD-7202579C932C wds:Q70075186-2A83E5C5-BBEA-42D8-B2C5-CC3015C2CE17 wds:Q70075186-3DFA9225-6218-4F17-ABB3-8D5C21D3C035 wds:Q70075186-41B805BC-142C-43A4-8512-D869AD4A3ABA wds:Q70075186-4D3457DE-2596-46F9-AEC1-D4943D188340 wds:Q70075186-890D73B5-848E-4096-9E9E-1CACF1D7E4C4 wds:Q70075186-A919FFC1-2D0A-4BA1-96A0-2C42F2A77AD2 wds:Q70075186-C854B7CC-28A0-4BC5-A3F0-5DEBA73C0D9D wds:Q70075186-DF619AB1-09A8-44B1-A585-5B886AD550E8 wds:Q70075186-FD54B87B-7BB3-4B1D-894A-6A9D00E6704B
author name string	K G Holden L H Hurley T Reck R P Hertzberg J R Hoover G Gallagher L F Faucette D R Langley D E Thurston S M Mong
rdfs:label	Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds (en) Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds (nl)
skos:prefLabel	Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds (en) Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds (nl)
name	Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds (en) Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds (nl)
title	wds:Q70075186-DC3F5F8F-AAD1-4596-8BDF-DD92080ACD7A
title	Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds (en)
page(s)	wds:Q70075186-A22D9266-98B8-455F-A267-2650F263B473
page(s)	258-268
instance of	wds:Q70075186-DF7A1AE7-6755-4C04-86E3-3CB66F321CF2
instance of	scholarly article
PubMed ID	wds:Q70075186-FEFAF3E1-0BA7-43E7-80B4-9C3D362CEA6A
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2979741
PubMed ID	2979741
published in	wds:Q70075186-7F0E64A3-7870-4F51-9727-22E0082BFBC5
published in	Chemical Research in Toxicology
issue	wds:Q70075186-F6258D12-9370-42C5-B320-A6C79CF20A39
volume	wds:Q70075186-31CB3393-EA4A-4F80-B085-77B4C1D6D401
issue	5
volume	1
DOI	wds:Q70075186-6E3A6D89-7425-459A-9D0C-D3E91F41BEC3
DOI	http://dx.doi.org/10.1021/TX00005A002
DOI	10.1021/TX00005A002
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q70075186
is cites work of	Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines Lexitropsins in antiviral drug development DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057. Cellular pharmacology of novel C8-linked anthramycin-based sequence-selective DNA minor groove cross-linking agents From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activity Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine Using Genome Sequence to Enable the Design of Medicines and Chemical Probes. Study of novel triazolo-benzodiazepine analogues as antidepressants targeting by molecular docking and ADMET properties prediction Pyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexes DNA minor-groove binders: results and design of new antitumor agents Synthesis and biological activity of fused tetracyclic Pyrrolo[2,1-c][1,4]benzodiazepines. Identification of the dioxygenase-generated intermediate formed during biosynthesis of the dihydropyrrole moiety common to anthramycin and sibiromycin Synthesis and Biological Evaluation of a Novel C8-Pyrrolobenzodiazepine (PBD) Adenosine Conjugate. A Study on the Role of the PBD Ring in the Biological Activity of PBD-Conjugates Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer Synthesis and cytotoxicity evaluation of novel C7-c7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates Time-resolved fluorescence studies of tomaymycin bonding to synthetic DNAs Sequence analysis of porothramycin biosynthetic gene cluster Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent. An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines Synthesis of aryl-substituted naphthalene-linked pyrrolobenzodiazepine conjugates as potential anticancer agents with apoptosis-inducing ability. A new and novel amide bond cleavage of N-methoxymethylpyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones by hydride reduction via 3-aza-Grob fragmentation Bispecific Antibodies and Antibody-Drug Conjugates for Cancer Therapy: Technological Considerations
is cites work of	wds:Q37764802-2D570728-173D-4950-8FDF-07B9BD630D85 wds:Q90138871-85B59BBC-5C56-40A5-88B6-669D2284FBF9 wds:Q28542060-6424E560-D54B-4CCA-AE0B-BAF98ED23EBD wds:Q33631711-5F449AF5-5C99-474B-9AD8-B600A648390C wds:Q52645748-A5DFA04B-1D5A-4D22-8117-8A12E33A0571 wds:Q90269121-EB7B6926-9107-4FFA-876C-1A55F5879C37 wds:Q38359507-FC5A95F5-B3AA-4AC1-9B9B-3C31F8B126E3 wds:Q35227295-6646B8C8-FD6E-4EDA-9F2E-F3DA7401253E wds:Q44568518-73A42360-C6C8-4948-8A85-F8ECEAFC2DC7 wds:Q34995823-B4E23FA1-767C-4EFE-8975-1123FEA2A3AB wds:Q26772938-643CF94B-E61B-41B5-8269-AA563DD3AE76 wds:Q29039532-75ACC1CF-1D19-4E1D-8479-22A87A6FA54C wds:Q38339530-DED04467-3549-4138-A768-49D6A2834B32 wds:Q36079502-CE3B62BD-240A-45F9-B6C3-898286805B06 wds:Q92192346-315C7199-60E5-4403-BD3B-1873502F98EA wds:Q33952790-E0D3A505-7A98-4CD9-BA24-92529261C718 wds:Q36496775-74F7DCD3-22E3-45EF-BE79-D51BBA176C6B wds:Q89545454-73856244-1BF0-45A8-AB0B-0BC34613D6B8 wds:Q92139776-E2F9FC12-75F7-4BDD-958A-6057092EC728 wds:Q39579617-AB102E1C-9802-40C6-A795-D2AFF8C8E041

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