About: The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+

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About: The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+ Goto Sponge NotDistinct Permalink

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scientific article published on 01 October 1985

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в жовтні 1985 (uk) article scientifique publié en 1985 (fr) im Oktober 1985 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu n'ochobre de 1985 (ast) scientific article published on 01 October 1985 (en)
publication date	wds:Q69977423-B2731C4A-A33F-4408-B422-F1E99220C36F
publication date	1985-10-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q69977423-5D0AE61E-1703-495F-B10F-4F60C23021C3
language of work or name	English
author name string	wds:Q69977423-0A15321A-758D-4783-BE96-0F6107B66BAB wds:Q69977423-0CA0223C-6112-420E-A6FE-26392E3AAFCE wds:Q69977423-2A9AC43D-90A4-40DC-BCF1-8E834070351F wds:Q69977423-2D96ED5E-7CDF-42A0-AA3E-5283A7C8E631 wds:Q69977423-8FBC9FF8-CEF9-47E4-A586-A6924747647C
author name string	S Nelson M Moore G Moore P Moldéus H Thor
rdfs:label	The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+ (en) The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+ (nl)
skos:prefLabel	The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+ (en) The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+ (nl)
name	The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+ (en) The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+ (nl)
author	wds:Q69977423-46B80D2A-7395-44AB-A862-F46B0EB944C7
author	Sten Orrenius
title	wds:Q69977423-83F0A611-860E-47C8-9999-C06F66849FD2
title	The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+ (en)
page(s)	wds:Q69977423-8372F8DB-6CEE-4F76-86DC-4E7D4DE50CD9
page(s)	13035-13040
instance of	wds:Q69977423-B01893CD-1517-473C-AE9B-C1B53E8501DA
instance of	scholarly article
main subject	wds:Q69977423-A428DBDA-3F34-43E7-83D6-27076EDB0A16
main subject	wd:Q57055
PubMed ID	wds:Q69977423-DC7D1B1A-519B-4427-9D91-CD78FBF0D13F
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2932433
PubMed ID	2932433
published in	wds:Q69977423-B0F01379-78B6-4D44-90B8-DB8F31612EDC
published in	Journal of Biological Chemistry
issue	wds:Q69977423-4A292268-3FEC-47BA-8C1B-9E07E35CC473
volume	wds:Q69977423-CF92C462-0428-43E6-86D9-DAB11F46DA28
issue	24
volume	260
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q69977423
is cites work of	Mechanisms of cell injury by activated oxygen species Effect of acetaminophen on glutathione levels in rat testis and lung Sulforaphane inhibits mitochondrial permeability transition and oxidative stress Extracellular calcium effects on cell viability and thiol homeostasis The role of acetylcysteine in clinical toxicology Teratogens inducing congenital abdominal wall defects in animal models Mechanisms of cell death Inhibition of carbamyl phosphate synthetase-I and glutamine synthetase by hepatotoxic doses of acetaminophen in mice Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice H2O2-induced cell death in human glioma cells: role of lipid peroxidation and PARP activation The amelioration of N-acetyl-p-benzoquinone imine toxicity by ginsenoside Rg3: the role of Nrf2-mediated detoxification and Mrp1/Mrp3 transports NQO2 is a reactive oxygen species generating off-target for acetaminophen. Effects of endurance training and exercise on tissue antioxidative capacity and acetaminophen detoxification. Prolonged high intracellular free calcium concentrations induced by ATP are not immediately cytotoxic in isolated rat hepatocytes. Changes in biochemical parameters implicated in cell toxicity 'Pore' formation is not required for the hydroperoxide-induced Ca2+ release from rat liver mitochondria Recent developments in the management of paracetamol (acetaminophen) poisoning Ameliorative effect of alkaloid extract of Cyclea peltata (Poir.) Hook. f. & Thoms. roots (ACP) on APAP/CCl4 induced liver toxicity in Wistar rats and in vitro free radical scavenging property Paracetamol toxicity in hamster isolated hepatocytes: the increase in cytosolic calcium accompanies, rather than precedes, loss of viability Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives Role of glutathione on renal mitochondrial status in hyperoxaluria Hepatoprotective effect of ethanolic extract of Trichosanthes lobata on paracetamol-induced liver toxicity in rats Blood gene expression markers to detect and distinguish target organ toxicity Temporal study of acetaminophen (APAP) and S-adenosyl-L-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity A general theory of chemical cytotoxicity based on a molecular model of the living cell, the Bhopalator Gene expression in rat hearts following oral administration of a single hepatotoxic dose of acetaminophen Aloe vera attenuated liver injury in mice with acetaminophen-induced hepatitis Effect of nifedipine, verapamil, diltiazem and trifluoperazine on acetaminophen toxicity in mice Auriculatone Sulfate Effectively Protects Mice Against Acetaminophen-Induced Liver Injury Reactive Metabolite-induced Protein Glutathionylation: A Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity Novel circulating- and imaging-based biomarkers to enhance the mechanistic understanding of human drug-induced liver injury Allyl alcohol cytotoxicity in isolated rat hepatocytes: mechanism of cell death does not involve an early rise in cytosolic free calcium The mechanism of thioacetamide-induced apoptosis in the L37 albumin-SV40 T-antigen transgenic rat hepatocyte-derived cell line occurs without DNA fragmentation Evaluation of the Protective Effects of Doxycycline on Acetaminophen-Induced Hepatotoxicity in Mice
is cites work of	wds:Q40787426-BD099101-8A9E-4823-9E98-56A9E27D4AD3 wds:Q67588010-2DEF6BED-B4D5-488E-9BF3-874942FE5CBF wds:Q35031394-8E254B48-00BC-4B2A-AA1D-1DE6269A4981 wds:Q35704201-B0391718-71FE-4E25-9A18-1134889900C4 wds:Q43202399-5ECEB13B-513F-49AB-80F4-7659AD04AA3C wds:Q39458222-717EB7D5-5FCD-4A05-A5F2-3FE4E6DCDAE6 wds:Q41787644-4A927FFB-89F8-4A3B-A7CC-CB9E0AEC6FF7 wds:Q34485517-2A9B6629-646C-417D-A2A8-0EAACB5466D3 wds:Q35648231-3C169A5A-1351-4E0B-944C-E3DCA4282538 wds:Q77327254-5E9A0583-B680-42FC-81D0-F5E42E79F910 wds:Q68027623-4703AD9D-B586-4500-A013-D115B691398E wds:Q90633259-CAA374E7-0E80-4A06-A248-810350003FF8 wds:Q90102147-19BF13C8-5651-4A70-86CF-B8EF6C52FE36 wds:Q92377619-F9694E8A-D227-4319-8CA4-52456C633E23 wds:Q92377698-B3CFC5D9-A167-4FE2-8C75-5D0852109A75 wds:Q23911101-B700C68D-F0DA-42E7-8546-3A47FB8B81DA wds:Q36368103-922A2B43-94C6-4142-9BC9-F81FB6A1AD79 wds:Q39139693-9E393C17-5311-4FA9-946E-0B8A548CB527 wds:Q37930248-D97E456D-9727-44DE-B86D-D009367C2BC3

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