About: Azinomycins A and B, new antitumor antibiotics. II. Chemical structures

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scientific article published on 01 November 1986

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в листопаді 1986 (uk) im November 1986 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 01 November 1986 (en) artículu científicu espublizáu en payares de 1986 (ast)
publication date	wds:Q69782806-25720F97-12DA-4115-859C-47CED8184892
publication date	1986-01-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q69782806-8198B705-5BD5-4FB3-8781-7747BE255FC5
language of work or name	English
access restriction status	wds:Q69782806-B1293CAA-D94C-4D5E-8B80-3B3F973BA3B2
access restriction status	open access
author name string	wds:Q69782806-37E87455-A0C6-4942-8422-AF5F2F0ABB97 wds:Q69782806-A82E76D6-A532-41EC-A7E8-974EC031E03D wds:Q69782806-B37C1063-D711-4FB8-A7CB-9C3DC0D3DB8A
author name string	T Nakashima K Yokoi K Nagaoka
rdfs:label	Azinomycins A and B, new antitumor antibiotics. II. Chemical structures (en) Azinomycins A and B, new antitumor antibiotics. II. Chemical structures (nl)
skos:prefLabel	Azinomycins A and B, new antitumor antibiotics. II. Chemical structures (en) Azinomycins A and B, new antitumor antibiotics. II. Chemical structures (nl)
name	Azinomycins A and B, new antitumor antibiotics. II. Chemical structures (en) Azinomycins A and B, new antitumor antibiotics. II. Chemical structures (nl)
title	wds:Q69782806-418D2143-E447-4092-B21D-BB7C3B4DDD7F
title	Azinomycins A and B, new antitumor antibiotics. II. Chemical structures (en)
page(s)	wds:Q69782806-D047AA2B-2D2E-416A-89A1-6EFA23EF3DB9
page(s)	4554-4561
instance of	wds:Q69782806-11E6CE31-BA27-4B23-AEE7-D4BF70861583
instance of	scholarly article
main subject	wds:Q69782806-0DD0B262-CEAD-48F2-9AD7-1EC4C24FBD15 wds:Q69782806-5F90275E-453F-47C1-AED0-1DCA70FDBD20 wds:Q69782806-6C63CBF6-1C39-4BC2-883E-F253C3CDA5AA wds:Q69782806-80D54868-FF35-4336-8192-FEB328CFD86B wds:Q69782806-91A282D4-F319-4982-B953-C88189EAE425 wds:Q69782806-A7976C9B-418E-45CE-8C45-A70B69891EE9 wds:Q69782806-BC4AD059-9D4D-4287-89E1-C7DF1B519FBC
main subject	Streptomyces Streptomyces griseofuscus Azinomycin carzinophilin a azinomycin A 3-Methoxy-5-methylnaphthalene-1-carboxamide [2-Amino-1-(2-methyloxiran-2-yl)-2-oxoethyl] 3-methoxy-5-methylnaphthalene-1-carboxylate
PubMed ID	wds:Q69782806-F9F3FABB-B4DC-420F-8642-8AC53C68AE22
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/3829181
PubMed ID	3829181
published in	wds:Q69782806-C4589430-CED1-4733-BDE9-5A3AAB637186
full work available at URL	wds:Q69782806-3521078C-C24F-4B5C-86B5-CB6EAA1841EB
published in	Chemical & Pharmaceutical Bulletin
full work available at URL	https://www.jstage.jst.go.jp/article/cpb1958/34/11/34_11_4554/_pdf
issue	wds:Q69782806-CD7EFAED-4CC9-417E-8D18-A686A90000A4
volume	wds:Q69782806-8E935ACA-C7A4-463A-ABFB-03D903F232E4
issue	11
volume	34
DOI	wds:Q69782806-19EB3A69-00FA-4984-A78A-2D9D62D548BB
DOI	http://dx.doi.org/10.1248/CPB.34.4554
DOI	10.1248/CPB.34.4554
online access status	wds:Q69782806-C8A0C3E0-F1CA-4A03-A27A-99EDFBA4E7F8
online access status	open access
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q69782806
is cites work of	Chasing molecules that were never there: misassigned natural products and the role of chemical synthesis in modern structure elucidation DNA Cross-Linking Agents as Antitumor Drugs Natural product DNA major groove binders Electrophilic natural products and their biological targets Azinomycins A and B, new antitumor antibiotics. I. Producing organism, fermentation, isolation, and characterization Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate Streptomyces sp. RM-14-6. Natural product hybrids as new leads for drug discovery Azinomycins A and B, new antitumor antibiotics. III. Antitumor activity. An improved method for culturing Streptomyces sahachiroi: biosynthetic origin of the enol fragment of azinomycin B. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis Studies on the mechanism of action of azinomycin B: definition of regioselectivity and sequence selectivity of DNA cross-link formation and clarification of the role of the naphthoate DNA cross-linking by azinomycin B: Monte Carlo simulations in the evaluation of sequence selectivity On the origin of the DNA sequence selectivity of the azinomycins Cellular effects induced by the antitumor agent azinomycin B. A molecular model for DNA cross-linking by the antitumor agent azinomycin B Mode of action and biosynthesis of the azabicycle-containing natural products azinomycin and ficellomycin. α,β-Dehydroamino acids in naturally occurring peptides Aziridine alkaloids as potential therapeutic agents Genome Mining of Amino Group Carrier Protein-Mediated Machinery: Discovery and Biosynthetic Characterization of a Natural Product with Unique Hydrazone Unit. Synthesis, structural characterization, antimicrobial and cytotoxic effects of aziridine, 2-aminoethylaziridine and azirine complexes of copper(II) and palladium(II). Previously Uncultured Marine Bacteria Linked to Novel Alkaloid Production Total Synthesis of Azinomycin A This work was supported by a grant from the National Cancer Institute (NIH CA-65875). A.N. was the recipient of a fellowship from the Spanish Ministerio de Educacion (EX0052672518). R.S.C. was an Alfred P. Sloan Found A Copper-Carbodiimide Approach to the Phomopsin Tripeptide Side Chain Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B. Truncated azinomycin analogues intercalate into DNA. A Synthetic Azinomycin Analogue with Demonstrated DNA Cross-Linking Activity: Insights into the Mechanism of Action of this Class of Antitumor Agent The authors gratefully acknowledge the financial support provided by the CRC and the EPSRC. We are i Role of the azinomycin naphthoate and central amide in sequence-dependent DNA alkylation and cytotoxicity of epoxide-bearing substructures Dependence of DNA sequence selectivity and cell cytotoxicity on azinomycin A and B epoxyamide stereochemistry. Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage Molecular modeling of DNA cross-linking analogues based on the azinomycin scaffold Covalent inhibitors design and discovery. Biosynthetic studies on the azinomycins: the pathway to the naphthoate fragment The first biosynthetic studies of the azinomycins: acetate incorporation into azinomycin B. Chemical synthesis and cytotoxicity of some azinomycin analogues devoid of the 1-azabicyclo[3.1.0]hexane subunit In vitro biosynthesis of the antitumor agent azinomycin B Sequence selectivity of azinomycin B in DNA alkylation and cross-linking: a QM/MM study Probing cytochrome P450-mediated activation with a truncated azinomycin analogue Essential role of an unknown gene aziU3 in the production of antitumor antibiotic azinomycin B verified by utilizing optimized genetic manipulation systems for Streptomyces sahachiroi Exploration of the molecular origin of the azinomycin epoxide: timing of the biosynthesis revealed

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