About: Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin

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About: Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin Goto Sponge NotDistinct Permalink

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scientific article published on 01 November 1989

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в листопаді 1989 (uk) article scientifique publié en 1989 (fr) im November 1989 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 01 November 1989 (en) artículu científicu espublizáu en payares de 1989 (ast) գիտական հոդված հրատարակված 1989 թվականի նոյեմբերի 1-ին (hy)
publication date	wds:Q69358276-DC7AA17B-378B-4554-80EE-27B9C7DB6C2A
publication date	1989-11-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q69358276-EDD6ED0D-775E-4F49-AD63-CA468D451C21
language of work or name	English
author name string	wds:Q69358276-4EADFB50-7E97-4CFF-89E9-038A82BC0BE5 wds:Q69358276-D8C1300A-82A1-4D29-B8C7-EB497307589F wds:Q69358276-E6D6F07A-4F33-47A8-A9C7-9334AB45C49D wds:Q69358276-F12CEA74-D4E7-4B9D-9D6D-BA9FB10A630C
author name string	Wang JC Benedetti P Bjornsti MA Viglianti GA
rdfs:label	Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin (en) Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin (nl)
skos:prefLabel	Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin (en) Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin (nl)
name	Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin (en) Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin (nl)
title	wds:Q69358276-B278DFFC-2A25-4DA8-9F1B-DFE08780BEA4
title	Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin (en)
page(s)	wds:Q69358276-9474C571-400D-49B7-9061-8117A0E34CE9
page(s)	6318-6323
instance of	wds:Q69358276-AB431FBF-23DE-4F6F-8D8C-5876515AAEAD
instance of	scholarly article
PubMed ID	wds:Q69358276-B58BCCB1-809B-4113-8808-538E26E2BB21
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2553253
PubMed ID	2553253
published in	wds:Q69358276-2278CF28-F680-46C3-B78D-C3A6B04C4D0E
published in	Cancer Research
issue	wds:Q69358276-7A60A9B0-0644-4A36-B0BC-5DE7C8C6AA1E
volume	wds:Q69358276-2A0A456D-F37A-44A8-9718-8D50ECFD36ED
issue	22
volume	49
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q69358276
is cites work of	Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition Using yeast to study resistance to topoisomerase II-targeting drugs. Structural studies of type I topoisomerases Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1 Targeted disruption of the mouse topoisomerase I gene by camptothecin selection Novel bacteriological assay for detection of potential antiviral agents Human DNA topoisomerase I: relaxation, roles, and damage control The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses Effect on DNA relaxation of the single Thr718Ala mutation in human topoisomerase I: a functional and molecular dynamics study Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I. Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2). A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor Human topoisomerase I mediates illegitimate recombination leading to DNA insertion into the ribosomal DNA locus in Saccharomyces cerevisiae Characterization of DNA topoisomerase I from Candida albicans as a target for drug discovery Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]- pyrene diol epoxide adducts at the 6-amino group of adenine In vitro mutagenesis and functional expression in Escherichia coli of a cDNA encoding the catalytic domain of human DNA ligase I. Association of the cytoplasmic membrane protein XpsN with the outer membrane protein XpsD in the type II protein secretion apparatus of Xanthomonas campestris pv. campestris Antitumor activity of a novel quinoline derivative, TAS-103, with inhibitory effects on topoisomerases I and II. Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico Rotation of DNA around intact strand in human topoisomerase I implies distinct mechanisms for positive and negative supercoil relaxation Sensitivity to anticancer agents and resistance mechanisms in clear cell carcinoma of the ovary Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance. Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages Doxorubicin inhibits human DNA topoisomerase I Immunohistochemical detection of DNA topoisomerase I in formalin fixed, paraffin wax embedded normal tissues and in ovarian carcinomas Topoisomerase I amino acid substitutions, Gly185Arg and Asp325Glu, confer camptothecin resistance in Leishmania donovani Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products. Yeast Saccharomyces cerevisiae as a model system to study the cytotoxic activity of the antitumor drug camptothecin Detection of functional protein domains by unbiased genome-wide forward genetic screening. Differential expression of topoisomerase I and RAD52 protein in yeast reveals new facets of the mechanism of action of bisdioxopiperazine compounds Potent antiviral activity of topoisomerase I and II inhibitors against Kaposi's sarcoma-associated herpesvirus Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily Replacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistant Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant. Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes. Effects of camptothecin or TOP1 overexpression on genetic stability in Saccharomyces cerevisiae. Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant. DNA-based sensor for real-time measurement of the enzymatic activity of human topoisomerase I A mechanistic and kinetic study of the E-ring hydrolysis and lactonization of a novel phosphoryloxymethyl prodrug of camptothecin Molecular characterization of recombinant Pneumocystis carinii topoisomerase I: differential interactions with human topoisomerase I poisons and pentamidine Identification and characterization of a deletion mutant of DNA topoisomerase I mRNA in a camptothecin-resistant subline of human colon carcinoma Efficacy of a Binuclear Cyclopalladated Compound Therapy for Cutaneous Leishmaniasis in the Murine Model of Infection with Leishmania amazonensis and Its Inhibitory Effect on Topoisomerase 1B. Topoisomerases and cancer chemotherapy: recent advances and unanswered questions A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism.
is cites work of	wds:Q24548135-0B7DFB71-27A0-4C67-864D-A3A95018CBB6 wds:Q24810359-B8B14C69-5574-49B7-BFFE-B46736DB50AA wds:Q34401367-A2557F3D-EA1E-449D-B818-22F644F0523F

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