About: The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase

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About: The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase Goto Sponge NotDistinct Permalink

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scientific article published on 28 August 2006

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) article scientifique publié en 2006 (fr) наукова стаття, опублікована в березні 2007 (uk) im März 2007 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 28 August 2006 (en) artículu científicu espublizáu n'agostu de 2006 (ast)
publication date	wds:Q64388322-9291A630-0361-41FF-8FE7-B56A215D8729
publication date	2006-08-28 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q64388322-EF6F7C71-14D3-41AC-B58D-D2DE1F7D9679
language of work or name	English
exact match	wds:Q64388322-B8070B82-E854-4F65-A606-2492FC5C5DDE
exact match	https://scigraph.springernature.com/pub.10.1038/sj.onc.1209927
cites work	wds:Q64388322-09A8B7FF-2BC4-41CD-A6E8-969DFF693ADC wds:Q64388322-0BE6EC13-DEFB-4DEE-BA30-1A0DC9016896 wds:Q64388322-14E6E4B2-9D01-4429-A7F6-2D450157B281 wds:Q64388322-1A8D75B9-C718-486F-AF73-A47B8E44ED88 wds:Q64388322-1ADE6081-5911-4BC8-BC1A-5C32692C2B79 wds:Q64388322-21859AC0-50FA-490E-B114-C25449C160D7 wds:Q64388322-2B6BA4A0-E3C4-4460-B945-A7CE92E4897F wds:Q64388322-2D89CB04-B0E5-49A4-B3EA-9A9FBDAE5DE9 wds:Q64388322-2E94C3C3-AC2C-4413-8F59-C59039AA74EF wds:Q64388322-2F028AD3-22F0-4020-B3E5-5AD1E6BF515B wds:Q64388322-33B783A5-A944-4B8E-9235-E13FD5581DD4 wds:Q64388322-3C5E9BAE-5E6F-49A3-BB4E-35E82F8002E5 wds:Q64388322-3F3FEE65-AE46-45FB-99F7-579B8896B0C4 wds:Q64388322-50AACAD4-3892-4196-B3DB-D2924F2AB023 wds:Q64388322-57507085-BDC2-445A-B6EB-7D94BEA1E27C wds:Q64388322-5BA58B65-F58C-4D20-8261-2741E6A0E850 wds:Q64388322-686E5476-ACED-4D0A-B81E-8E15393AF623 wds:Q64388322-687419EA-A494-4529-9BC8-2CFD1149790A wds:Q64388322-70880192-9AD4-475B-A362-49D37C6D91DD wds:Q64388322-7E8E92C6-7A73-45D1-ABC1-48B01008A8AA wds:Q64388322-83150ED4-9636-4817-9A92-6E89AB9A397F wds:Q64388322-8BDA0BF8-8475-450E-B4E4-EEB09B3BD48F wds:Q64388322-9349B57D-CF7C-4FF5-B250-B916254E68B0 wds:Q64388322-93899460-7ACC-4C66-A0DE-17FD5536EA27 wds:Q64388322-96210C44-78DD-43F8-96F6-5B295CE1B2DA wds:Q64388322-B4021B6E-D349-46FE-895E-13437E0F0886 wds:Q64388322-B678C151-A41B-4FFB-894C-C2AF6E585EA4 wds:Q64388322-B8C42B67-2548-47A0-A3FA-2DE925641E0E wds:Q64388322-BC05B68B-8265-4535-AC74-CCFC68796FA6 wds:Q64388322-BF8C4E3D-71B9-4734-94F5-9C496BECFE90 wds:Q64388322-C718C32B-F8DD-4EA6-9313-B26EAA470A36 wds:Q64388322-CD556F26-78E1-46A1-80FE-8EA095CB4758 wds:Q64388322-D583151F-4294-4D66-B2EB-EB4AAEB71578 wds:Q64388322-E4251AE3-B951-4681-ADE7-4A96A841789C wds:Q64388322-F11A4D3F-1B4D-42A6-8EAA-88E628D7D027
cites work	Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro DNA damage-induced activation of p53 by the checkpoint kinase Chk2 The Chk2 protein kinase The DNA damage response: putting checkpoints in perspective Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks Plant PP2C phosphatases: emerging functions in stress signaling PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage Chk2 activation and phosphorylation-dependent oligomerization Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. Chk1 and Chk2 kinases in checkpoint control and cancer Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. Characterization of tumor-associated Chk2 mutations Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis Chk2 molecular interaction map and rationale for Chk2 inhibitors Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents Substrate specificity of the human protein phosphatase 2Cdelta, Wip1 Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control The 17q23 amplicon and breast cancer Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice. The regulation of CHK2 in human cancer
author name string	wds:Q64388322-2C31DB78-80E9-43E6-B239-F0E2C2F8E7FF wds:Q64388322-362570F9-48D8-49BC-A5C7-57EC39E40078 wds:Q64388322-48F5AFEE-85DE-47BF-AFF4-74F9151FE987 wds:Q64388322-9E05F33B-4038-47B1-92FF-5BEEA3FA8976 wds:Q64388322-9F676B16-8E42-4A31-95B8-A996A9DD6B93 wds:Q64388322-A144CA05-65CD-466A-A476-1068CEB4A056
author name string	C Ducrot V Berthonaud A Chevalier F Leteurtre M Oliva-Trastoy M-C Marsolier-Kergoat
rdfs:label	The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase (en) The Wip1 phosphatase (nl)
skos:prefLabel	The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase (en) The Wip1 phosphatase (nl)
name	The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase (en)

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