About: An improved synthesis of adefovir and related analogues

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scientific article published on 29 March 2019

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rdf:type	Item
description	wetenschappelijk artikel (nl) bài báo khoa học (vi) artículu científicu espublizáu en marzu de 2019 (ast) наукова стаття, опублікована у 2019 (uk) im Januar 2019 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 29 March 2019 (en)
publication date	wds:Q64100797-6647FABF-0029-4BA5-B730-9A8959F9D993
publication date	2019-03-29 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q64100797-6A4135A3-80F1-43DF-91C4-9548CE330641
language of work or name	English
cites work	wds:Q64100797-075C1333-AA22-4BEC-A01B-C607CACA8FE7 wds:Q64100797-1275B411-A39B-4145-8AF3-3E53FC4C568A wds:Q64100797-1A40B6B1-62F3-4030-BCF7-A1B75CDF47CC wds:Q64100797-1B6EE507-6AEE-4C21-8A1E-08CF8BCC33DD wds:Q64100797-1F92E641-1986-4021-B7AA-93328405770C wds:Q64100797-2414FA10-3ABC-4A1E-B010-A065BF3F1DBE wds:Q64100797-243A469F-F912-4B43-BD6A-CC1E39A9FE2F wds:Q64100797-30C427D4-3285-4BE0-9DA2-B813F3A87F66 wds:Q64100797-32B4479A-DCD0-495C-9A1D-A8A76A73F15F wds:Q64100797-33A4A78C-4ED8-4064-A235-E0047A0A7ECF wds:Q64100797-3521A1A3-FCC5-4B55-AB62-1A7B0ECFB65E wds:Q64100797-37926DBF-78A3-4CF5-97CE-45B80BB2C1A8 wds:Q64100797-3C8971C3-24AA-4170-BD5B-338DBFEE794C wds:Q64100797-41826C03-FC37-405C-B234-0C788E2B001D wds:Q64100797-449EAB41-E81B-4A29-A925-3B1811FC926A wds:Q64100797-66822691-246C-403E-9675-E718AC4F3178 wds:Q64100797-6864C4A7-F374-4DDE-B5D8-BFA173792CB2 wds:Q64100797-6C05D6EA-86DA-4181-917A-60FF29276D20 wds:Q64100797-6D130E85-3138-42CB-8675-4155A0370874 wds:Q64100797-73CE09F2-ADD1-4C6D-B617-00157446B6FD wds:Q64100797-779A7F9C-9348-4087-A817-160D4D71DB06 wds:Q64100797-834BEB55-6890-46A0-9448-34A25792E0E7 wds:Q64100797-83836AA3-7528-48B4-B289-64E8CC64B75E wds:Q64100797-8AA301D5-A839-4064-9CF6-27B6C16B5D17 wds:Q64100797-9860CE0A-6842-4A42-8881-8F8BB1679143 wds:Q64100797-9931293A-B3AA-4D19-8CC4-C5DB0A5A8C81 wds:Q64100797-99901740-16BB-4AF3-9758-F676AF19D4B0 wds:Q64100797-99DCC74A-CAF4-48E2-9D93-8C1D2CCBCBAA wds:Q64100797-9E8CF14E-0BE6-4E83-858F-3DC786B0B927 wds:Q64100797-A145275E-0F21-452F-B434-C43307AA3FEB wds:Q64100797-A59633C3-5AA2-4F03-AD8B-2492D2981584 wds:Q64100797-B033F490-631E-4D9C-84BC-322336532191 wds:Q64100797-B859D030-283E-4710-80D0-DF4AC29D0E80 wds:Q64100797-BA7E37C5-C490-4321-8386-A91E937A73FF wds:Q64100797-BFE09A39-ECE8-4740-A4AE-02B1F1B99F2B wds:Q64100797-C61929C7-48A4-4121-8F8A-CBCF661BFABE wds:Q64100797-D28255B7-4907-4ED7-AB57-7B5370671E44 wds:Q64100797-D33DFD5E-8875-42C1-8CC9-DBF9BC101156 wds:Q64100797-D7AC6ED1-687F-408D-910F-36EC28535B0A wds:Q64100797-DA04A91D-94CA-4D68-81D8-F9A87A519CD5 wds:Q64100797-E807C183-70B9-42CF-985F-C5B1AF745BF0 wds:Q64100797-E9CCE121-4FDB-4D3C-AE9B-5DACABA51FE9 wds:Q64100797-F7F1AE57-7D2A-4BD9-8567-62C664F67871
cites work	Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine Adefovir dipivoxil: a review of its use in chronic hepatitis B. A novel selective broad-spectrum anti-DNA virus agent Dihydrolevoglucosenone (Cyrene) as a bio-based alternative for dipolar aprotic solvents. Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro Synthesis of nucleoside phosphate and phosphonate prodrugs Nephrotoxicity, including acquired Fanconi's syndrome, caused by adefovir dipivoxil - is there a safe dose? Acyclic nucleoside phosphonates: a key class of antiviral drugs Adefovir dipivoxil in chronic hepatitis B infection Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA. Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability The ProTide Prodrug Technology: From the Concept to the Clinic Design and synthesis of novel bis(L-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity A novel class of phosphonate nucleosides. 9-[(1-phosphonomethoxycyclopropyl)methyl]guanine as a potent and selective anti-HBV agent Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity Amidines and guanidines in medicinal chemistry. Some new acyclic nucleotide analogues as antiviral prodrugs: synthesis and bioactivities in vitro. Acyclic nucleoside bisphosphonates: synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity. Synthesis and in vivo evaluation of prodrugs of 9-[2-(phosphonomethoxy)ethoxy]adenine cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids Inhibition of hepatitis B virus (HBV) replication by pyrimidines bearing an acyclic moiety: effect on wild-type and mutant HBV. Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Novel α-Borano-Nucleotide Analogues of 9-[2-(Phosphonomethoxy)ethyl]adenine and (R)-9-[2-(Phosphonomethoxy)propyl]adenine Application of ionic liquid to polymorphic transformation of anti-viral/HIV drug adefovir dipivoxil Curious discoveries in antiviral drug development: the role of serendipity 2,3-Dicyclohexylsuccinimide as a directing/protecting group for the regioselective glycosylation or alkylation of purines Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses New prodrugs of Adefovir and Cidofovir Anti-retroviral and pharmacological properties of 9-(2-phosphonylmethoxyethyl) adenine (PMEA). 2-Amino-6-arylthio-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) esters as novel HBV-specific antiviral reagents Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine
author name string	wds:Q64100797-77BCBBE2-E84A-4620-BB6D-381D70F2544D
author name string	Eileen M O'Leary
rdfs:label	An improved synthesis of adefovir and related analogues (en)

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