About: A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize

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About: A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize Goto Sponge NotDistinct Permalink

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scientific article published on 09 April 2019

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rdf:type	Item
description	wetenschappelijk artikel (nl) article scientifique publié en 2019 (fr) наукова стаття, опублікована у 2019 (uk) artículu científicu espublizáu n'abril de 2019 (ast) im Januar 2019 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 09 April 2019 (en)
publication date	wds:Q64063524-E99DD6BC-A649-47AA-9CE3-261F44E07DDA
publication date	2019-04-09 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q64063524-EECAC87E-BAEA-4E33-A0E0-A29B507815AE
language of work or name	English
cites work	wds:Q64063524-130CD376-7703-4400-A63A-D72C517260C9 wds:Q64063524-1E9AA57D-80D2-4762-9A3C-A97DADA99C0E wds:Q64063524-2909433E-7BDF-4D8D-82B5-AB74C8C96C70 wds:Q64063524-2AD689FE-5FF6-499A-B162-5F6DB914555C wds:Q64063524-2AD69BE7-74E5-4420-8B2B-C770F517FDEF wds:Q64063524-2BF61625-EADF-43E3-9942-AE91A83B80B4 wds:Q64063524-31F6A87B-9231-4395-A73B-FB3909E05AE5 wds:Q64063524-37F9B2BE-EF1B-4B4D-B886-910BE21E9F3C wds:Q64063524-3860FBC0-20C0-4913-9654-BDE1F49B3363 wds:Q64063524-41DFC040-F244-458D-A7E8-F38A57B49123 wds:Q64063524-44968210-4F54-4388-8C1E-55378E486FCE wds:Q64063524-46424B04-90C7-4620-ABAA-4D380595AA9C wds:Q64063524-490A939D-8EE3-4AE1-9672-36E4D347901E wds:Q64063524-5F300A8A-865A-45AB-BFF5-BAABD5B09A5D wds:Q64063524-76F0A062-5567-4C90-9902-77D00871312A wds:Q64063524-8382A58B-1834-4B34-99CC-21BB27C53816 wds:Q64063524-8982BAC6-7185-4CC0-AF09-1D9E3954EAA1 wds:Q64063524-8F91084B-6500-4899-9AD0-966CC89477D4 wds:Q64063524-9369CE50-80E2-4A3C-946F-30E48B125A2F wds:Q64063524-962E01FD-6142-4ED0-A69E-B602A3E08B6B wds:Q64063524-9EEF338D-F815-4BDD-A844-E730380856A6 wds:Q64063524-AAF81A4D-F0D2-4805-A2A6-EF7A15DC163F wds:Q64063524-B0D3D67F-CDB5-48E7-9320-6BA7817C080B wds:Q64063524-B67736B8-F112-4195-91A0-AEC0B31B46D6 wds:Q64063524-B7DA8A40-5C3B-48B0-93F0-B55B1041B741 wds:Q64063524-B9F30E53-F737-4B6C-95DF-EDCAED847720 wds:Q64063524-BAF8F7B4-15A8-4679-8B8E-E33749A419ED wds:Q64063524-C0B53EBE-2270-4822-94E1-FD339D9E5D81 wds:Q64063524-C3E321E6-200B-4A76-A0C3-76447608B67C wds:Q64063524-C4460B01-8FC9-447C-801E-264C50918B8E wds:Q64063524-C6BCC224-6B2D-4075-AF6A-355F681ECC88 wds:Q64063524-CCFBAF2F-5EE5-49F3-B3CA-3674E1A56958 wds:Q64063524-D2280DE5-9340-483A-86D0-BAC8E6AA2CD7 wds:Q64063524-D3F24434-3501-43BA-A0C0-8007200EEB18 wds:Q64063524-D89EF869-9341-4BF6-A36D-3B3130EA1479 wds:Q64063524-E28BC942-E889-4717-B6F7-F5A8516B0F6C wds:Q64063524-EA3C6815-5A24-4B36-A990-F3AB2FF6685F wds:Q64063524-EBD98B66-1DDA-499A-ADA2-51B5FDE2EF8E wds:Q64063524-EFD2B7B7-DFE1-4394-AB83-C5A3FD247100 wds:Q64063524-F0EA9D98-AD86-449D-B1EC-2A05B1E393E0 wds:Q64063524-F8D5D68C-105B-4424-BCA0-A8484A2C1FDE
cites work	MDMX: a novel p53-binding protein with some functional properties of MDM2 Regulating the p53 pathway: in vitro hypotheses, in vivo veritas RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation The MDM2 gene amplification database Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53 Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 Critical contribution of the MDM2 acidic domain to p53 ubiquitination HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Critical role for a central part of Mdm2 in the ubiquitylation of p53. Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. The contribution of the acidic domain of MDM2 to p53 and MDM2 stability Turning the RING domain protein MdmX into an active ubiquitin-protein ligase The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53 The RING domain of Mdm2 can inhibit cell proliferation An essential function of the extreme C-terminus of MDM2 can be provided by MDMX Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans MDM2 interacts with MDMX through their RING finger domains Mutual dependence of MDM2 and MDMX in their functional inactivation of p53 Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. Mapping of the p53 and mdm-2 interaction domains Hdmx stabilizes Mdm2 and p53 The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity Autoinhibition of MDMX by intramolecular p53 mimicry MDMX contains an autoinhibitory sequence element Autoactivation of the MDM2 E3 ligase by intramolecular interaction Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity. Anatomy of Mdm2 and Mdm4 in evolution. A site-directed mutagenesis study of the MdmX RING domain COZOID: contact zone identifier for visual analysis of protein-protein interactions.
author name string	wds:Q64063524-3C7F34C7-EC35-4611-83B5-8B1662DB310D wds:Q64063524-41474858-A960-48A4-B803-1BB4B2D2521A wds:Q64063524-B6E3A1B3-0B30-4B5F-9665-3FAC1EA55948
author name string	Amandine Verlande Barbora Valčíková Pavlína Kosztyu
rdfs:label	A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize (en)

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