About: Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

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About: Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis Goto Sponge NotDistinct Permalink

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scientific article published on 20 March 2019

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rdf:type	Item
description	wetenschappelijk artikel (nl) 2019年學術文章 (zh) article scientifique publié en 2019 (fr) artículu científicu espublizáu en marzu de 2019 (ast) im April 2019 veröffentlichter wissenschaftlicher Artikel (de) наукова стаття, опублікована у квітні 2019 (uk) scientific article published on 20 March 2019 (en)
publication date	wds:Q62997191-C286EE3F-7F43-4C86-8D64-FA570D2DB1C3
publication date	2019-03-20 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q62997191-FE8E8DB3-BC17-408C-9E09-FD24EA63BE4B
language of work or name	English
cites work	wds:Q62997191-01F1BABE-4D72-4928-95A0-52429706754D wds:Q62997191-05F03628-0D47-40AF-B17F-9A476F8F1F63 wds:Q62997191-13B4C3C6-20C7-4703-A111-BE2A450F1150 wds:Q62997191-28C9045C-58FE-4181-810A-0A56F397BD16 wds:Q62997191-295DD163-19DB-4CF6-9C8C-77ABB499949F wds:Q62997191-37459635-7FE0-4BE4-B583-EC9AF7421DC1 wds:Q62997191-3EF44EFC-F35B-4FA6-B33F-841508FB78D5 wds:Q62997191-45EFECED-6E98-49C8-B33C-01BD3982D15F wds:Q62997191-48E80C82-2E23-4FF3-9839-A8259D980B0B wds:Q62997191-4D164994-176B-41B7-8BA8-8491FF97CEE9 wds:Q62997191-5C40E1A4-6A1E-4320-8F0F-67D63C2A2522 wds:Q62997191-68E50432-EF3E-4DFB-BD58-21C901CA61DE wds:Q62997191-6C47927F-6CAF-4F80-839A-163DB1F9E029 wds:Q62997191-748136C0-708B-494E-91F8-A3632E697B62 wds:Q62997191-81C3950F-2062-43EE-9110-73F91957B25A wds:Q62997191-88772A64-AB32-437E-B427-45100DEF2711 wds:Q62997191-A3DB219C-BE1E-4154-84D4-83B3DFEACE79 wds:Q62997191-A49E3197-82B0-4225-B952-53388E3C62EB wds:Q62997191-A56899CC-1C04-465E-96EE-3E83AA75E78E wds:Q62997191-AAACFCE6-A52C-4183-B495-A73123CB7A38 wds:Q62997191-AB88A745-4AAD-4E99-98D3-33BAF59F9A20 wds:Q62997191-BA9C326D-1625-487C-83F1-F8665E451ED3 wds:Q62997191-C7606C27-0F1A-40E9-80F2-74986B005E39 wds:Q62997191-DA7EDBB8-DF4E-41B4-9589-790E282F8043 wds:Q62997191-DFF7D1B3-534F-45D0-A148-DAD20F94468B wds:Q62997191-E1F34C8B-8383-4E98-9667-C8CB6A92E53C wds:Q62997191-E437B07D-BEB8-4CB1-A7AD-88E281E0405C wds:Q62997191-E7388452-BD8F-4417-A076-DB5CF9F76A55 wds:Q62997191-E7D100A1-90D8-4FAB-AD57-82BF884F74CF wds:Q62997191-E9AFF2A8-B627-4573-8F29-293D8E0B5A7B wds:Q62997191-F2BD2859-A86E-4D18-B2D0-548D61FA99C8 wds:Q62997191-FB453FF6-82CA-41A9-BE93-46AF3A8FD467
cites work	Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study A novel multiple-stage antimalarial agent that inhibits protein synthesis Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum. A genomic glimpse of aminoacyl-tRNA synthetases in malaria parasite Plasmodium falciparum A continuous spectrophotometric assay for inorganic phosphate and for measuring phosphate release kinetics in biological systems Structure of the unusual seryl-tRNA synthetase reveals a distinct zinc-dependent mode of substrate recognition Thousands of chemical starting points for antimalarial lead identification pH regulation in the intracellular malaria parasite, Plasmodium falciparum. H(+) extrusion via a V-type H(+)-ATPase. Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum. High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial. Bioluminescent assays for ADMET BRENDA in 2017: new perspectives and new tools in BRENDA. A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open Access Malaria Box. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors The Burden of Cryptosporidium Diarrheal Disease among Children < 24 Months of Age in Moderate/High Mortality Regions of Sub-Saharan Africa and South Asia, Utilizing Data from the Global Enteric Multicenter Study (GEMS) Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study Structure-Based Targeting of Orthologous Pathogen Proteins Accelerates Antiparasitic Drug Discovery Childhood stunting in relation to the pre- and postnatal environment during the first 2 years of life: The MAL-ED longitudinal birth cohort study Cryptosporidiosis Drug Discovery: Opportunities and Challenges Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification Drug targeting of one or more aminoacyl-tRNA synthetase in the malarial parasite Plasmodium falciparum. Challenges and recent progress in drug discovery for tropical diseases Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor. Asymmetric total synthesis of cladosporin and isocladosporin Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection Structural characterization of human aminoacyl-tRNA synthetases for translational and nontranslational functions
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