About: -Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer

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About: -Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer Goto Sponge NotDistinct Permalink

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scientific article published on 17 February 2017

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rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в березні 2017 (uk) im März 2017 veröffentlichter wissenschaftlicher Artikel (de) scientific article published on 17 February 2017 (en) artículu científicu espublizáu en febreru de 2017 (ast)
publication date	wds:Q62511374-AD241FCC-7047-48FD-8944-8BA48D316E06
publication date	2017-02-17 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q62511374-BD02F8A6-E5CD-421B-97A1-74AF8A67F96A
language of work or name	English
cites work	wds:Q62511374-041EE698-C54A-4614-9E7A-36ACF99BE41D wds:Q62511374-055CBD89-9C93-4308-AB3A-ED247DF8C7D8 wds:Q62511374-10026194-0607-48B8-B1E7-E6550B9203EA wds:Q62511374-13E4F0C3-03BD-4D12-A1AC-542515D42B6E wds:Q62511374-2406CBFA-4D9F-4B70-869B-98E6DA608D26 wds:Q62511374-2F627392-2390-4B40-8E8D-80AF0DB4C234 wds:Q62511374-33B606CE-EA20-443A-934F-1972FEAF4CE3 wds:Q62511374-456ACCA9-FED5-46B7-98FF-7D03E76C7D43 wds:Q62511374-4625A920-000A-46A6-BE7F-34D22B6FB22C wds:Q62511374-4CD58171-CF35-4990-A6FF-89B187CE37DE wds:Q62511374-4F3C41F5-3A6A-4E74-B4DD-448D8181DB89 wds:Q62511374-510D3430-28F8-4A3E-8987-5B53DC1BF52B wds:Q62511374-53356F64-CCF1-4D6F-9191-009A6D101504 wds:Q62511374-5CE6BA26-A412-4894-A2E8-22B75ACB3656 wds:Q62511374-5DD7490F-FADD-4365-99C5-4D91EB7FDF11 wds:Q62511374-62316F8E-29E0-4784-A95A-4571B6F404D2 wds:Q62511374-70140803-554A-4978-AA51-51A789309080 wds:Q62511374-79DEBD50-3CD6-4DA1-994A-1F4249B8EA14 wds:Q62511374-7E0298C6-EE6A-4C00-BA36-1094787CC066 wds:Q62511374-7E6E2D7A-DB85-4E2F-B0B3-1A2B3ADA24AE wds:Q62511374-820EA378-49C6-42AC-AD5A-337B4EFB2A40 wds:Q62511374-82A2EC68-D239-4389-866F-D3CDA16D4344 wds:Q62511374-864B9537-2CD2-4FB7-8803-5236B0A4CD86 wds:Q62511374-88DF2F13-1BF8-468E-B273-A342A0D172EE wds:Q62511374-A1719629-B0B3-426A-BA5A-4E715DC4E18E wds:Q62511374-AA42542C-27AF-4AD1-97FF-4EC21CA9E2F8 wds:Q62511374-B30F9A78-D2E8-4D6D-A474-EE3F969BAC64 wds:Q62511374-B3EDC3CE-FD22-4DD8-B4D6-659CE15DCA34 wds:Q62511374-C5F65126-7582-4A5E-840C-DC98F6DAFE77 wds:Q62511374-CD4EDF19-53EE-4397-BF93-B68A22B7F024 wds:Q62511374-CE84210B-2F9D-4467-AF68-F7BF43114D80 wds:Q62511374-D833B290-B5F1-4841-8839-2B0C7CD1D61E wds:Q62511374-E2E9E0B8-D5DD-485A-97AA-B5A1E2C7762A wds:Q62511374-EDD7536C-913D-4B1D-B100-E317E6FA41A2 wds:Q62511374-F1109E1D-9C9D-4898-91E7-CF209125A97A wds:Q62511374-F1D05949-B3CD-4E48-BEF6-D91E955ADC6B wds:Q62511374-F582137C-EE55-455E-8B1E-04D422278833 wds:Q62511374-F89E4594-F88D-4994-A4EF-1211D24324B1
cites work	Establishment and identification of small cell lung cancer cell lines having classic and variant features. Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties Small-cell lung cancer A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity Autocrine and paracrine signaling through neuropeptide receptors in human cancer [D-Arg1,D-Trp5,7,9,Leu11]substance P: a novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cells Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro A review of first-line treatment for small-cell lung cancer Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Use of the post-insertion technique to insert peptide ligands into pre-formed stealth liposomes with retention of binding activity and cytotoxicity. Comparison of alamar blue and MTT assays for high through-put screening Spectroscopic characterization of the inclusion complex of a luteinizing hormone-releasing hormone agonist, buserelin acetate, with dimethyl-beta-cyclodextrin Small cell lung cancer Cyclodextrins in peptide and protein delivery [Arg6,D-Trp7,9,NmePhe8]-substance P (6-11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism Multiple neuropeptides stimulate clonal growth of small cell lung cancer: effects of bradykinin, vasopressin, cholecystokinin, galanin, and neurotensin Expression of V1A and GRP receptors leads to cellular transformation and increased sensitivity to substance-P analogue-induced growth inhibition. CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8]-substance P (6-11)-induced growth inhibition Calcium-dependent growth regulation of small cell lung cancer cells by neuropeptides Neuropeptide receptor status in human tumor cell lines New short-chain analogs of a substance-P antagonist inhibit proliferation of human small-cell lung-cancer cells in vitro and in vivo Forearm blood flow and local responses to peptide vasodilators: a novel pharmacodynamic measure in the phase I trial of antagonist G, a neuropeptide growth factor antagonist Irradiation Decreases the Neuroendocrine Biomarker Pro-Opiomelanocortin in Small Cell Lung Cancer Cells In Vitro and In Vivo Growth of small cell lung cancer cells: stimulation by multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. Dual AO/EB staining to detect apoptosis in osteosarcoma cells compared with flow cytometry Amplification and expression of protooncogenes in human small cell lung cancer cell lines. Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides A synergetic screening approach with companion effector for combination therapy: application to retinoblastoma A new prenylated indole derivative from endophytic actinobacteria Streptomyces sp. neau-D50. Radiotherapy in small-cell lung cancer: lessons learned and future directions Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction. Direct, chemoselective N-tert-prenylation of indoles by C-H functionalization Emerging drugs for small cell lung cancer--an update The lipid-associated 3D structure of SPA, a broad-spectrum neuropeptide antagonist with anticancer properties.
author name string	wds:Q62511374-2241924C-DE38-4925-B5C8-F771D3A17694 wds:Q62511374-ADAEA4FD-9282-4EA0-84C5-BE5D00372B38 wds:Q62511374-B664305D-998A-4B67-B8E8-65D58EAEC7D6
author name string	Sally Freeman Gavin Brown Manikandan Kadirvel
rdfs:label	-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer (en) -Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer (nl)
skos:prefLabel	-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer (en) -Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer (nl)
name	-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer (en) -Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer (nl)
author	wds:Q62511374-4068D57E-C0CB-449A-97D6-AAE4C48545FA wds:Q62511374-681CD762-360A-46D9-9A59-4B93C5DA7FF0

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