About: A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts

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About: A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts Goto Sponge NotDistinct Permalink

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scientific article published on 01 May 1993

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в травні 1993 (uk) article scientifique publié en 1993 (fr) im Mai 1993 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en mayu de 1993 (ast) scientific article published on 01 May 1993 (en)
publication date	wds:Q61819266-A0374A82-D7EA-451F-85E2-50DFA81A759B
publication date	1993-05-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q61819266-41064719-C231-4C97-9396-FC5A2B9768F1
language of work or name	English
author name string	wds:Q61819266-98B39412-2028-471B-BBE4-0CF7E18E1005 wds:Q61819266-C60B1452-4C0D-4303-AA0F-CE3F357CD3D9 wds:Q61819266-CA7DECDC-44F1-404A-AC9B-43C0B5B8106A wds:Q61819266-E2B898C4-5F94-4644-96E1-3395041A0704
author name string	Davies B East N Brown PD Crimmin MJ
rdfs:label	A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts (en) A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts (nl)
skos:prefLabel	A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts (en) A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts (nl)
name	A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts (en) A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts (nl)
author	wds:Q61819266-16EA1C10-7406-4DC0-880D-DCD0D6B812E8
author	Fran Balkwill
title	wds:Q61819266-2CAABED1-3A43-4CE2-BAA4-E4EF6E63C163
title	A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts (en)
page(s)	wds:Q61819266-DE716543-1344-4FAD-A986-CD29FB1B1F22
page(s)	2087-2091
instance of	wds:Q61819266-4D8D9504-7500-4B25-977F-706B7D7B8B51
instance of	scholarly article
main subject	wds:Q61819266-2689480C-B562-4EA0-A45C-452191D024D8 wds:Q61819266-96B09300-2E9D-4EFA-B7E2-D13FB95B480A
main subject	ovarian carcinoma xenograft
PubMed ID	wds:Q61819266-03B3D63D-EBC0-44F7-AD87-FA1E34D0CD1C
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8347186
PubMed ID	8347186
published in	wds:Q61819266-BD2B8CE3-DD42-4F52-8481-3D9A0C6EB921
published in	Cancer Research
issue	wds:Q61819266-6D2985F3-3CD4-44EC-BED2-7E97F5406640
volume	wds:Q61819266-CC1D160B-EF52-4852-8E72-0A20E990C99E
issue	9
volume	53
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q61819266
is cites work of	TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma Matrix metalloproteinases in remodeling of the normal and neoplastic mammary gland Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. Inhibitors of collagenase but not of gelatinase reduce cartilage explant proteoglycan breakdown despite only low levels of matrix metalloproteinase activity Is there new hope for therapeutic matrix metalloproteinase inhibition? Dynamin participates in focal extracellular matrix degradation by invasive cells A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer Metalloproteinase-mediated release of human Fas ligand Ovarian cancer cell invasion is inhibited by paclitaxel Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase-9 with enhanced expression in a model of membranous nephropathy The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin. Matrix metalloproteinase inhibitors: present achievements and future prospects Matrix metalloproteinase inhibitors The matrix metalloproteinases and their inhibitors in pancreatic cancer. From molecular science to a clinical application Angiogenesis and antiangiogenic strategies in pancreatic cancer Establishment of an in vitro assay to measure the invasion of ovarian carcinoma cells through mesothelial cell monolayers Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complex The tetracycline analogs minocycline and doxycycline inhibit angiogenesis in vitro by a non-metalloproteinase-dependent mechanism Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d) Rodent pharmacokinetic and anti-tumor efficacy studies with a series of synthetic inhibitors of matrix metalloproteinases Matrix metalloproteinase inhibitors: applications in oncology. Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model Apical enrichment of human EGF precursor in Madin-Darby canine kidney cells involves preferential basolateral ectodomain cleavage sensitive to a metalloprotease inhibitor Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis The matrix metalloproteinase inhibitor batimastat inhibits angiogenesis in liver metastases of B16F1 melanoma cells Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data Proteolysis of extracellular matrix by invadopodia facilitates human breast cancer cell invasion and is mediated by matrix metalloproteinases Selection of a histidine-containing inhibitor of gelatinases through deconvolution of combinatorial tetrapeptide libraries Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding Clinical potential of matrix metalloprotease inhibitors in cancer therapy A systems approach to cancer therapy. (Antioncogenics + standard cytotoxics-->mechanism(s) of interaction). Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor Molecular targeted therapy in ovarian cancer: what is on the horizon? Inhibition of estrogen-induced pituitary tumor growth and angiogenesis in Fischer 344 rats by the matrix metalloproteinase inhibitor batimastat. Effect of matrix metalloproteinase inhibition on pancreatic cancer invasion and metastasis: an additive strategy for cancer control MMP-9 regulates both positively and negatively collagen gel contraction: a nonproteolytic function of MMP-9. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones Proteinase inhibitors reduce basement membrane degradation by human breast cancer cell lines. Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Inhibition of tumour growth by marimastat in a human xenograft model of gastric cancer: relationship with levels of circulating CEA IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth Exploiting changes in the tumour microenvironment with sequential cytokine and matrix metalloprotease inhibitor treatment in a murine breast cancer model TGFbeta1 stimulates the secretion of matrix metalloproteinase 2 (MMP2) and the invasive behavior in human ovarian cancer cells, which is suppressed by MMP inhibitor BB3103 Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis Proteases and the biology of glioma invasion Regulation of monocyte MMP-9 production by TNF-alpha and a tumour-derived soluble factor (MMPSF). Unstimulated human acute myelogenous leukemia blasts secrete matrix metalloproteinases Matrix metalloproteinase 2 (MMP-2) immunoreactive protein is associated with poor grade and survival in brain neoplasms CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover Breast cancer angiogenesis--new approaches to therapy via antiangiogenesis, hypoxic activated drugs, and vascular targeting Roles of extracellular nucleotides and P2 receptors in ectodomain shedding

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