About: Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study

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description	article (en) հոդված (hy) wetenschappelijk artikel (nl) наукова стаття, опублікована в листопаді 2011 (uk) im Oktober 2011 veröffentlicher wissenschaftlicher Artikel (de)
publication date	wds:Q60895639-DDEF8E19-8806-4FB4-B73C-148A2B69014D
publication date	2011-10-17 00:00:00Z (xsd:dateTime)
cites work	wds:Q60895639-0E78E054-DD2B-4BBF-A711-39E6F943A360 wds:Q60895639-160F4F98-856F-4EB8-987D-49BD7EF201B9 wds:Q60895639-2A957158-80E2-4225-89AA-EB0992DF170B wds:Q60895639-2DFF475A-797B-4E3B-9B5F-851B63BC58A4 wds:Q60895639-33786FB8-82F8-40D7-9DFF-50AFCB382D91 wds:Q60895639-33BF034D-2E1C-4B4C-8376-6D07E44374CB wds:Q60895639-377A87BA-4B95-4DD6-9895-05A5E61267C7 wds:Q60895639-3D532EFE-5E34-4F92-8FF6-BC8911A0E581 wds:Q60895639-402E46E8-617F-462D-868F-95185514A9A4 wds:Q60895639-481560BC-784F-46DC-9F40-C06056C80B3D wds:Q60895639-49C86785-9B56-4B21-A900-C64CE1BBEA46 wds:Q60895639-50F8147B-FF5B-484D-A5AE-F853320D6810 wds:Q60895639-515B4829-04BA-4B04-A3F3-64FD8C0B8DE3 wds:Q60895639-658CB4D2-8BA8-419D-893C-B08C259523AC wds:Q60895639-75D6BD89-FE9B-41DF-8E5D-6FF4338715F0 wds:Q60895639-75E725FD-2575-47BA-8F2B-53ACD32367F3 wds:Q60895639-8299C4A3-1127-4CFD-B45E-577C47999289 wds:Q60895639-839E9C68-F67F-495F-AB65-055F0D7C4277 wds:Q60895639-88921DF7-9CC9-415D-9EE3-3270D9470B59 wds:Q60895639-890234EC-A36D-49A6-819A-AB35F8A59CA1 wds:Q60895639-8A1FAAB5-2E63-45FF-8721-6AE12A60E739 wds:Q60895639-9583249A-EAC0-40AF-952A-F72372F7A3EC wds:Q60895639-9EA91B24-4C11-488E-B83F-80A7E35A4CBD wds:Q60895639-A77132A3-87D1-4A99-AB3E-9414682942EF wds:Q60895639-B5A24EBC-82D7-443E-ABDB-D0383485783F wds:Q60895639-C93E6077-90D6-4C03-88FD-2FC0FB11C399 wds:Q60895639-DFF5580E-8B9B-4D5C-9BD4-26669053AA0F wds:Q60895639-E21584C1-A4CC-4D27-A155-E7F840E9C70C wds:Q60895639-EA804EFB-973F-4D41-B765-651F650DAF7B wds:Q60895639-EAE3F754-473E-4391-A204-107D9E774A55
cites work	Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Molecular basis for sunitinib efficacy and future clinical development ABCG2 421C>A polymorphism and high exposure of sunitinib in a patient with renal cell carcinoma Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib Resistance to targeted therapy in renal-cell carcinoma Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes. Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with sunitinib Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity The role of vascular endothelial growth factor genetic variability in cancer The efficacy and safety of sunitinib in korean patients with advanced renal cell carcinoma: high incidence of toxicity leads to frequent dose reduction Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2. Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis. Overall survival and updated results from a phase II study of sunitinib in Japanese patients with metastatic renal cell carcinoma Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers. The relationship of VEGF polymorphisms with serum VEGF levels and progression-free survival in patients with epithelial ovarian cancer Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles
author name string	wds:Q60895639-1F5BBA95-BF41-4BA9-BAA8-4C3890422F31 wds:Q60895639-2076E4E7-2186-4D6B-8D90-6B359FC6AD73 wds:Q60895639-3129644B-AB35-41B2-89AB-0725A6112516 wds:Q60895639-451C8E42-D09B-4A08-B6EF-BAF32DA2B44E wds:Q60895639-7CD444B8-8002-4685-9814-4C608EC95139 wds:Q60895639-A7956B48-E7CC-4B40-92B4-CA27BB2D66BE wds:Q60895639-C53ABF30-254C-4C7E-862F-1ADAF041BA06 wds:Q60895639-D8C4AD2D-4B14-4615-8777-B67A823ED377 wds:Q60895639-FDF94B24-A853-4B1B-8F6C-F2060D5E5E2D wds:Q60895639-FECC5F93-1097-40E4-B1E4-9BF4325DBB72
author name string	Joaquim Bellmunt Fernando Moreno Albert Font Miguel Angel Climent Begoña Mellado Javier Puente Esther Martínez José Angel Arranz Daniel E Castellano Aranzazu González del Alba
rdfs:label	Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study (en) Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study (nl)
skos:prefLabel	Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study (en) Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study (nl)
name	Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study (en) Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study (nl)
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