About: Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers*

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About: Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers* Goto Sponge NotDistinct Permalink

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scientific article published on 01 September 1996

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована у вересні 1996 (uk) im September 1996 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en setiembre de 1996 (ast) scientific article published on 01 September 1996 (en)
publication date	wds:Q60678569-6F8D8FBE-D5AC-493E-995A-8F2BD4043D65
publication date	1996-09-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q60678569-C8BD5999-508D-4DE1-9785-E5D548E546DA
language of work or name	English
cites work	wds:Q60678569-02DE48DA-5F97-41E6-9B6F-B30802305015 wds:Q60678569-04511850-BF2C-466B-BEDD-8D5DC8E57D71 wds:Q60678569-058352B0-596E-4E0B-AE9A-DE4F6A27F6C2 wds:Q60678569-0585CCB4-EFFA-4D9F-9921-0BCC70BDC144 wds:Q60678569-0D82A13C-C97D-47C7-97F4-2E66B3370A04 wds:Q60678569-1267B3AD-C4BF-4EDF-9233-7D8CEFA6EBF0 wds:Q60678569-17BF723C-6329-40DA-8E18-CFB376C96C77 wds:Q60678569-1CB40105-CE0F-4CA3-8910-FA0EE07DD10D wds:Q60678569-2003238B-4C7C-4678-957B-B836F78B90A5 wds:Q60678569-246FFC87-27A2-4883-9511-AD5CB30341F6 wds:Q60678569-253318CC-1B5F-40BF-8508-B4A6D7D572FC wds:Q60678569-2DF385E5-604A-4B78-9B0A-2BE9BE06919E wds:Q60678569-368292F3-3F06-4DEA-A8F1-A29BAEDE3016 wds:Q60678569-3B071BD3-02E5-4C99-824D-B8AA620DE11D wds:Q60678569-40B6862C-C204-4D11-A9EF-D79F3522A85D wds:Q60678569-5EB5CBFB-2C88-41CA-A5A8-758F383EEF1D wds:Q60678569-61B4BD5C-9AD7-45A6-BBDF-D26A59AFAC31 wds:Q60678569-669BCB90-E997-42A2-B930-B63EF6BF4684 wds:Q60678569-6A1AD2F3-4999-494D-A46E-DB68ED043D2D wds:Q60678569-6EF42F5A-023F-4734-8F78-1C65E32C1252 wds:Q60678569-8D0384C7-9605-4E30-8283-B0FF3B92BD08 wds:Q60678569-95E1475A-2CE9-4719-9CC0-936358310A76 wds:Q60678569-977370BF-5D7E-43D1-9FBE-4414A966146C wds:Q60678569-AC0BAC9F-E2A3-4E8E-ACB0-5338C5F60B87 wds:Q60678569-B1BD68CC-3FB5-46C6-A73F-230E5F97C597 wds:Q60678569-BCD04C43-35B4-425F-8831-ECD97925C427 wds:Q60678569-CAC0BECE-F2F6-4AC4-B5C9-9F158FC4C3F1 wds:Q60678569-D50F9E48-24B1-4A45-8EFD-91DE2B217E01 wds:Q60678569-D58027E6-235C-4236-8E71-2990CA68FB42 wds:Q60678569-E3D869EA-B476-4E07-B4A7-95F719981F87 wds:Q60678569-ED5CC4A2-6ED1-422E-B040-3F597F846387
cites work	Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide Analysis of morphine and its 3- and 6-glucuronides by high performance liquid chromatography with fluorimetric detection following solid phase extraction from neonatal plasma Steady-state infusions of opioids in human. II. Concentration-effect relationships and therapeutic margins. Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity. Morphine-6-glucuronide: effects on ventilation in normal volunteers Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position Analgesic Effect of Morphine Glucuronides The analgesic activity of morphine-6-glucuronide The metabolite morphine-6-glucuronide contributes to the analgesia produced by morphine infusion in patients with pain and normal renal function Disposition of morphine-6-glucuronide and morphine in healthy volunteers Oral morphine in cancer pain: influences on morphine and metabolite concentration Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations Concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide in serum and cerebrospinal fluid following morphine administration to patients with morphine-resistant pain. Chronic morphine therapy for cancer pain: plasma and cerebrospinal fluid morphine and morphine-6-glucuronide concentrations. Explanation for potency of repeated oral doses of morphine? The Metabolism of Morphine and Heroin in Man Extrahepatic morphine metabolism in man during the anhepatic phase of orthotopic liver transplantation. Gene expression in oestrogen-dependent human breast cancer xenograft tumours Analgesic efficacy and CSF pharmacokinetics of intrathecal morphine-6-glucuronide: comparison with morphine Linear systems analysis in pharmacokinetics Human brain metabolism of morphine and naloxone A polyexponential deconvolution method. Evaluation of the "gastrointestinal bioavailability" and mean in vivo dissolution time of some ibuprofen dosage forms. Multiple morphine and enkephalin receptors: biochemical and pharmacological aspects Morphine and morphine metabolite kinetics in the rat brain as assessed by transcortical microdialysis. Fast reliable assay for morphine and its metabolites using high-performance liquid chromatography and native fluorescence detection Numerical stability of pharmacokinetic deconvolution algorithms Estimation of the rate and extent of chiral inversion using linear systems analysis Metabolite formation pharmacokinetics: rate and extent of metabolite formation determined by deconvolution Opioid receptor agonist potencies of morphine and morphine-6-glucuronide in the guinea-pig ileum Pharmacokinetics of morphine in patients following orthotopic liver transplantation.
author name string	wds:Q60678569-1BFC5047-2C6F-481B-87D2-D7D45C00DFE7 wds:Q60678569-2CA8718D-44A8-4865-8CA4-9CBCE7F594A2 wds:Q60678569-6F3BAC49-2E2D-48F7-BBCC-A9269C146B3B wds:Q60678569-74B286FD-A555-4213-9C8F-613CCC059C1D wds:Q60678569-E837056B-45FA-4577-A447-B10B5F5B4FAE wds:Q60678569-ED51A0DB-7741-4DF9-8AC4-2F3C48F306C9
author name string	G Geisslinger R Waibel K Brune N Schmidt G Kobal A Stockmann
rdfs:label	Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers* (en) Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers* (nl)
skos:prefLabel	Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers* (en) Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers* (nl)
name	Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers* (en) Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers* (nl)
author	wds:Q60678569-EF27C091-E151-4C2B-BBE8-A25CBA8C89E0
author	Jörn Lötsch
title	wds:Q60678569-FBC77423-0496-416E-9777-D22215265379
title	Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers (en)
page(s)	wds:Q60678569-FA96B7FA-DF29-4BBD-8CEC-FD92BC992D3A
page(s)	316-325
instance of	wds:Q60678569-F2A504DB-380D-4C86-87C6-B83C58DC04AD
instance of	scholarly article
main subject	wds:Q60678569-008BA24F-320C-478B-B713-D7EC58150A62 wds:Q60678569-653763D8-8C62-46BE-B9E8-EBB9FD04AE48

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