About: Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

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About: Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro Goto Sponge NotDistinct Permalink

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scientific article published on 01 July 1998

Attributes	Values
rdf:type	Item
description	wetenschappelijk artikel (nl) наукова стаття, опублікована в липні 1998 (uk) article scientifique publié en 1998 (fr) im Juli 1998 veröffentlichter wissenschaftlicher Artikel (de) artículu científicu espublizáu en xunetu de 1998 (ast) scientific article published on 01 July 1998 (en)
publication date	wds:Q60407939-D586F786-0901-4FD4-9B8C-B869273DE4A7
publication date	1998-07-01 00:00:00Z (xsd:dateTime)
language of work or name	wds:Q60407939-2CC08EAA-E20A-4836-BDF2-B1AC147EFBCD
language of work or name	English
author name string	wds:Q60407939-02E23792-B91D-46AF-AD2B-81FDD513FE63 wds:Q60407939-0EF6B5D6-542E-4692-8A56-F40FE2260557 wds:Q60407939-169A6798-C943-44F4-9680-3350B59BC548 wds:Q60407939-3401FE32-6FAE-489A-A6D7-4AE9172F9564 wds:Q60407939-652848E2-F205-4354-8313-3A5BD074BD32 wds:Q60407939-658A2AC6-6748-4648-8CEF-CBA3E32D18EE wds:Q60407939-6E506E52-C9A5-4345-AEFF-1A97C3E8DB9D wds:Q60407939-7FC5DD93-321D-424A-AAEE-25F411358963 wds:Q60407939-96E0C4F1-B687-4091-A312-574C55E0CAF2 wds:Q60407939-9B887E1D-2FEA-42F8-BE9B-B1DF559C9AD8 wds:Q60407939-B81CE12D-9006-46FE-8BCD-FCB97D8B0F51 wds:Q60407939-D99970B5-5E90-483A-92C9-F8D628E72EC8
author name string	N Robertson P Wardman J Nolan G E Adams M Jaffar M R Stratford S A Everett M A Naylor K B Patel M F Dennis E Swann S D Lockyer
rdfs:label	Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro (en) Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro (nl)
skos:prefLabel	Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro (en) Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro (nl)
name	Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro (en) Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro (nl)
author	wds:Q60407939-0B480CBF-53AB-49F5-8966-4FC165FA71D9 wds:Q60407939-EA081D38-B231-4E11-A9DB-983B5D28F8D6
author	Ian J Stratford Christopher J. Moody
title	wds:Q60407939-7AC618EA-6A5B-490F-B410-88B9CCEDA63F
title	Indolequinone antitumor agents: reductive activation and elimination from (5-methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro (en)
page(s)	wds:Q60407939-82557956-3B4F-4CDF-84C3-5C1BDF56F299
page(s)	2720-2731
instance of	wds:Q60407939-E5364C8E-BAD9-48DB-9F75-EDE989FDEDDC
instance of	scholarly article
main subject	wds:Q60407939-16D69CE1-5213-4B02-AB51-5E463727BBA6
main subject	hypoxia
PubMed ID	wds:Q60407939-BCDAEBF5-46C8-4E06-9A39-495E33246780
PubMed ID	http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9667963
PubMed ID	9667963
published in	wds:Q60407939-BF23D80C-C393-49E3-A87D-838A40BDF584
published in	Journal of Medicinal Chemistry
issue	wds:Q60407939-FB8E090F-914B-4A27-9831-2B8EF70BC309
volume	wds:Q60407939-5569E097-FCB7-4930-A886-44D050417A17
issue	15
volume	41
number of pages	wds:Q60407939-9EC3A18D-BB3D-4061-80DA-367E13F311CF
number of pages	12 (xsd:decimal)
DOI	wds:Q60407939-C61501BA-49E2-4619-BA87-D0C24B6E50D2
DOI	http://dx.doi.org/10.1021/JM970744W
DOI	10.1021/JM970744W
is about of	https://www.wikidata.org/wiki/Special:EntityData/Q60407939
is cites work of	NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity Bioreductive and gene therapy approaches to hypoxic diseases Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9. Synthesis and anticancer and anti-HIV testing of some pyrazino[1,2-a]benzimidazole derivatives Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II 2-nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: reductively triggered release of the PARP inhibitor 5-bromoisoquinolinone Prodrugs for targeting hypoxic tissues: regiospecific elimination of aspirin from reduced indolequinones 3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro. Cytotoxicity of RH1 and related aziridinylbenzoquinones: involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress. Hypoxia-targeted drug delivery Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion Radiation- and photo-induced activation of 5-fluorouracil prodrugs as a strategy for the selective treatment of solid tumors. Bioreductively-activated prodrugs for targeting hypoxic tissues: elimination of aspirin from 2-nitroimidazole derivatives
is cites work of	wds:Q28142533-F047884A-FF5E-4D2F-907E-AB7BF37C5ADE wds:Q40743994-0812124F-D9E5-49B0-B9B3-BC3E3696F4D5 wds:Q78139204-13931FDD-B3F2-4759-9302-D3651D4C9623 wds:Q78139207-DAB3E232-C961-46AA-A0F5-278F146F70FC wds:Q35831668-09DD61BB-AC2C-48C2-A494-2092585F3DE2 wds:Q77788021-6FDAB762-39AD-49B9-857D-4D6460DC4EF2 wds:Q36876799-341A5B85-9A9D-4377-AF71-E6B5CFDE0384 wds:Q35044683-5526CEB1-AA66-4EC3-BCBA-096FC6986454 wds:Q43990738-3068E547-67FA-4BDA-AE07-DDD0A046F589 wds:Q34455176-398303B7-E532-4891-8478-73DA33CE0C8C wds:Q78173943-815D02FA-803B-4425-A894-A1CC56E26B1C wds:Q34028119-E6DF30CA-DE0C-47BC-BDA2-C78B304265F3 wds:Q40574833-A311CA8E-8A31-463D-8B9B-AC26685A3E42 wds:Q61799902-5035CA7C-236C-4A6F-822B-99E041372F8D wds:Q37284613-B244D281-19DD-4B6B-BA87-73D9B259753D wds:Q40632205-3AEC97E6-0A19-4B23-A70F-DD548613B434

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